My "scape plan" method (boof barbiturate + intranasal opioid)

[rotciv]

Well, I have 20 grams of Thiopental bought in India and 500mg of Protonitazepyne (a more potent analogue than fentanyl) on the way. This is my "escape plan" when my world comes crashing down.

After much experimentation and study, the plan is to dissolve 10g of thiopental in 10ml of warm water (giving a total of 15ml of liquid) and inject it into my rectum. But first prepare two lines of Proto with around 125mg each (which should be the maximum I can snort before falling asleep), so after boofing I can snort with each nostril.

I chose to combine barbiturates with opioids for faster mortality and their strong synergy. And given the fact that I want to do it in a hotel room, I prob have less than 24 hours to be successful.

Well, it was the best I could get without going to Latin America and I think it will be more quickly and quietly deadly than Pentobarbital alone.


I'll have 10 grams of Thiopental and 250 mg of Protonitazepyne left over and I'll bury it and make a map for you guys find it hahahahaha



PS: RIP to my friends @eashanm @Alpercino that I meet personally in this journey

 

[INTJme]

Wishing you luck!

 

[Justnotme]

Did you order these substances over the Internet to your country with delivery from India? Do I understand correctly?
So you got these substances in the mail?
And what kind of store can I find out?

And is it really pure substances there, and not deception?

 

[rotciv]

Did you order these substances over the Internet to your country with delivery from India? Do I understand correctly?
So you got these substances in the mail?
And what kind of store can I find out?

And is it really pure substances there, and not deception?

tiopental I had it in India in a pharmacy.

some nitazenes can be purchased on research chemicals websites in some countries.

 

[Six feet down]

Nitazenes is more potent than fentanyl and it is possible to buy?
I am from Europe, can i buy it online?

 

[Endisclose]

Well, I have 20 grams of Thiopental bought in India and 500mg of Protonitazepyne (a more potent analogue than fentanyl) on the way. This is my "escape plan" when my world comes crashing down.

After much experimentation and study, the plan is to dissolve 10g of thiopental in 10ml of warm water (giving a total of 15ml of liquid) and inject it into my rectum. But first prepare two lines of Proto with around 125mg each (which should be the maximum I can snort before falling asleep), so after boofing I can snort with each nostril.

I chose to combine barbiturates with opioids for faster mortality and their strong synergy. And given the fact that I want to do it in a hotel room, I prob have less than 24 hours to be successful.

Well, it was the best I could get without going to Latin America and I think it will be more quickly and quietly deadly than Pentobarbital alone.


I'll have 10 grams of Thiopental and 250 mg of Protonitazepyne left over and I'll bury it and make a map for you guys find it hahahahaha



PS: RIP to my friends @eashanm @Alpercino that I meet personally in this journey

Is 250 mg of protonitazepyne good enough to ctb on its own or are you just using it as a potentiator?

 

[rotciv]

Is 250 mg of protonitazepyne good enough to ctb on its own or are you just using it as a potentiator?

Problably good enough but I'm still using as potentiator

 

[Endisclose]

Problably good enough but I'm using as potentiator

How much time would it take once you snort it to fall unconscious
a) by itself
b) combined with the thio

I wonder how you test the protonitazepyne as well.. I've never really snorted anything before.. Do people use it recreationally? How much mg does it take to get a high I wonder?

 

[rotciv]

How much time would it take once you snort it to fall unconscious
a) by itself
b) combined with the thio

I wonder how you test the protonitazepyne as well.. I've never really snorted anything before.. Do people use it recreationally? How much mg does it take to get a high I wonder?

I don't have experience using it sorry

 

[Endisclose]

I don't have experience using it sorry

You haven't? I am amazed you are planning to use it for the first time to ctb. You sir have my respect .

 

[rotciv]

You haven't? I am amazed you are planning to use it for the first time to ctb. You sir have my respect .

RC opioid - snort or take in capsules?

Thinking about ODing on an RC opioid (protonitazene) along with some other drugs (bromazolam, alcohol & carisoprodol). These will be taken orally but I'm unsure whether to snort the opioid or use capsules. If I use capsules the proto would be put inside size 1 enteric acid resistant capsules...

sanctioned-suicide.net

 

[DeadManLiving]

What a coincidence I just got my proto and metoni yesterday, 1 G of each. Although I do have a tolerance I totally passed out after reeling a small microspec of the proto.

Woke up with scars all over my head. What I wonder is if I was in any respiratory distress during the period I blacked out. I guess one could call this a quasi overdose, or mega nod out.

One alternative that you should consider I'm doing is getting eccentric coated capsules that only burst in the lower intestine, past the duodenum where regurgitation is not possible and the small intestines are just going to have to absorb a mega dose.

Interesting to find someone who's in the same boat or at least using the same method. I have a bunch of RC benzos to combine with. The objective I assume is to achieve respiratory arrest and ultimately failure without waking up found halfway there with permanent brain damage.

That's really what's holding me back, in part because of permatolerance to Opiods and benzos the question is getting this perfect without permanent brain damage from hypoxia.


Which is where my second layer method comes in and that is liquid nitrogen. I'm going to essentially evaporate 10 L of liquid nitrogen in my vehicle cabin which should be enough to nitrogen blanket and create a oxygen deficient atmosphere so if one of the other fails I at least have a failsafe. But there are so many variables.

Barbiturates definitely a lot more lethal indeed, so I may add them to the mix.

I think the only guaranteed lethal approach here is IV drip or just plunging direct in an epic dose.

Isonitoetazine it has one of the strongest respiratory arrest and protracted recovery time lags of five different zenes according to a paper I read and is the most lethal.

I also have one gram of pyro on the way.

I'm really on the edge with any half measures because I'm afraid of permanent brain damage in the event of being found so logistics and location is also another critical point.

May I DM you and maybe we can compare notes and chat?

 

[Endisclose]

RC opioid - snort or take in capsules?

Thinking about ODing on an RC opioid (protonitazene) along with some other drugs (bromazolam, alcohol & carisoprodol). These will be taken orally but I'm unsure whether to snort the opioid or use capsules. If I use capsules the proto would be put inside size 1 enteric acid resistant capsules...

sanctioned-suicide.net

I had no idea these sorts of posts existed around here. But definitely respect to you guys for thinking outside the box and looking at other methods.

 

[rotciv]

Isonitoetazine it has one of the strongest respiratory arrest and protracted recovery time lags of five different zenes according to a paper I read and is the most lethal.

Could you share the paper?

Barbiturates definitely a lot more lethal indeed, so I may add them to the mix.


May I DM you and maybe we can compare notes and chat?

Barbiturates ain't more letal than fentanyl.

 

[DeadManLiving]

Could you share the paper?


Barbiturates ain't more letal than fentanyl.

Sorry I meant barbs def more lethal than benzos I meant to say. Obviously fent way more lethal.

Here is the paper, very interesting to look at the chart of N-desethyl isotonitazene delayed reversion from (over)dose to the mean recovery time of similar opiods in the respiratory inhibition curves.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10320493/

Particularly in figure 4C you can see the respiratory depression apnea and recovery curves and it's profoundly steep and magnitude in acute depression effects with a longer lag to recovery.




Quoting from the paper

To compare the respiratory depressant effects of N-desethyl isotonitazene and fentanyl, we used phrenic nerve activity using a well-established decerebrate rabbit model where pO2 and pCO2 were maintained constant throughout drug administration.32 This setup allows monitoring of more consistent drug effects compared to whole-body plethysmography where baseline ventilation as well as the magnitude of respiratory depression are more variable due to the respiratory effects of behavior and activity level. Phrenic nerve recordings were performed without background anesthetic and under physiologically relevant conditions.32 Since isotonitazene is currently a DEA-scheduled compound, we instead chose to test its metabolite, N-desethyl isotonitazene in these respiratory-depression assays, especially toward the hypothesis that nitazene active metabolites may contribute to respiratory-depressant effects. We administered each drug intravenously (IV) at 1 μg/kg to determine onset kinetics and, second, we titrated repeated small boluses (1–4 μg/kg) until apnea was achieved. When the doses were titrated to produce apnea, N-desethyl isotonitazene required less than half (3.5 ± 0.3 μg/kg, n = 6) of the dose required to cause complete apnea by fentanyl (9.0 ± 0.5 μg/kg, n = 4, p < 0.001) (Figure 4B) indicating 2-fold increased potency by IV administration. A single equal dose (1 μg/kg) of N-desethyl isotonitazene induced greater respiratory depression (59 ± 2% of baseline respiratory rate, n = 6) compared to fentanyl (75 ± 3%, n = 3, p < 0.001) (Figure 4C). The time to maximal effect for the 1 μg/kg dose was approximately 4 times longer for N-desethyl isotonitazene (10.5 ± 1 min) than for fentanyl (2.5 ± 0.5 min, p < 0.001) (Figure 4C), and the time of recovery from apnea to baseline respiratory rate was approximately 3 times longer for N-desethyl isotonitazene (208 ± 38 min) compared to fentanyl (67 ± 9 min, p = 0.018) (Figure 4D). Importantly, injection of the non-selective opioid receptor antagonist naloxone completely reversed apnea for the 3 μg/kg dose N-desethyl isotonitazene within 5.5 ± 0.6 min, n = 6 (Figures 4E and 4F). This reversal effect is similar to the time to complete reversal of fentanyl-induced respiratory depression reported previously.36 Taken together, these data show that a primary metabolite of isotonitazene, N-desethyl isotonitazene, is a more potent respiratory depressant capable of decreasing respiration to a greater extent and for a longer duration compared to the conventional opioid fentanyl.

 

[Sunset Limited]

The combination of propofol + fentanyl is used to test the airway resistance of patients with obstructive sleep apnea. Although propofol alone is sufficient, fentanyl is added to reduce the dose required to suppress the respiratory reflex.

Opiates have a strong synergy with GABA-A receptor agonists in respiratory depression. I don't think anyone has a chance of survival with 20 grams of thiopental + 500 mg of protonitazepyne. Be aware that rectal thiopental can work very quickly. Good luck.

 

[Mayonaise]

I'm growing interested in this method.
Unfortunately, there's not much info to be found regarding Thiopental lethal dose, time to death and routes of administration. But generally speaking, rectal administration (boofing) should ensure greater absorption than oral route, not to mention the absence of emesis (vomiting). 2-5 grams IV is definitely lethal but difficult to administer.

Here a fellow member linked to a study which is interesting but incoherent in some passages. I'm attaching a medical paper about a suicide involving rectal administration of this drug.

A 43 year old, 135-lb white female nurse anesthetist was found dead following rectal administration of 6.5 gm of Pentothal Sodium (the brand name for sodium thiopental).
Toxicological screenings were negative for common toxicants, including alcohol and other depressants.

The suggested dosage for the drug rectally is 1 gm/75 Ib and a dose of 3-4 gm for adults weighing 200 Ib or more should not be exceeded.
In the present case, the apparent rectal dose was 6.5 gm or approximately 3.6 gm/75 lb. For several hours following administration of barbiturates, the concentration in the liver is many times higher than that in the blood. In the present case, the concentration ratio of the liver/blood is 8/1, which suggests a rapid death, probably within 5 to 10 min after rectal administration. Thiopental is rapidly absorbed via the rectal route with an onset of action beginning within 10 min.

The victim was a medical professional so she probably knew what she was doing.
Conclusion: boofing this drug does seem to work.

 

[Sunset Limited]

I'm growing interested in this method.
Unfortunately, there's not much info to be found regarding Thiopental lethal dose, time to death and routes of administration. But generally speaking, rectal administration (boofing) should ensure greater absorption than oral route, not to mention the absence of emesis (vomiting). 2-5 grams IV is definitely lethal but difficult to administer.

Here a fellow member linked to a study which is interesting but incoherent in some passages. I'm attaching a medical paper about a suicide involving rectal administration of this drug.

A 43 year old, 135-lb white female nurse anesthetist was found dead following rectal administration of 6.5 gm of Pentothal Sodium (the brand name for sodium thiopental).
Toxicological screenings were negative for common toxicants, including alcohol and other depressants.

The suggested dosage for the drug rectally is 1 gm/75 Ib and a dose of 3-4 gm for adults weighing 200 Ib or more should not be exceeded.
In the present case, the apparent rectal dose was 6.5 gm or approximately 3.6 gm/75 lb. For several hours following administration of barbiturates, the concentration in the liver is many times higher than that in the blood. In the present case, the concentration ratio of the liver/blood is 8/1, which suggests a rapid death, probably within 5 to 10 min after rectal administration. Thiopental is rapidly absorbed via the rectal route with an onset of action beginning within 10 min.

The victim was a medical professional so she probably knew what she was doing.
Conclusion: boofing this drug does seem to work.

Gray area of reliability. We don't know what caused the nurse's death. There are two possibilities.

- Thiopental-induced apnea
- Airway collapse

Both are possible. If she died of airway collapse, that doesn't guarantee CTB for everyone.

Still putting an airtight bag on the head can solve the problem.

 

[Mayonaise]

Gray area of reliability. We don't know what caused the nurse's death. There are two possibilities.

- Thiopental-induced apnea
- Airway collapse

Both are possible. If she died of airway collapse, that doesn't guarantee CTB for everyone.

Still putting an airtight bag on the head can solve the problem.

Thanks for your expertise. Would you please explain the difference between the two?

 

[Sunset Limited]

Thanks for your expertise. Would you please explain the difference between the two?

I will try to explain. Below is a study done with thiopental in children. Thiopental was administered rectally for procedural sedation. The dose administered for procedural sedation was 25mg/kg. This shows that absorption is quite slow. Of course, compared to IV administration. If we ignore the fact that the induction dose rate is lower in adults, procedural sedation induction dose is 1750mg for an average of 70kg healthy person with no drug addiction.

Procedural sedation is a method used in endoscopy, colonoscopy... that allows the patient to breathe spontaneously. The anesthesia induction dose (that stops breathing) is usually twice that. In fact, the induction dose with thiopental is specific and titrated. If we continue with the numbers, 50mg/kg is the rectally administered anesthesia induction dose. So, 3500mg for an average of 70kg healthy person with no drug addiction. So this is the upper limit of the therapeutic dose.

According to your attached case report, the nurse was exposed to 3.6 times the upper limit of therapeutic dose. Without any other drugs. So she must be around 50-60kg. The question is: would this dose administered rectally maintain respiratory arrest to 0% desaturation? To answer this, pharmacokinetic simulation is needed for rectal thiopental. Also, the plasma concentration of thiopental that would initiate an apnea. Remember that these numbers can be quite specific. Factors include fat, age, health, drug addiction...

Back to the nurse, maybe she stopped breathing at some point, the hypercapnic reflex returned breathing but she could not protect the airway, just like in obstructive sleep apnea. The reflexes that would wake you up when the airway collapses in obstructive sleep apnea are still there. Not if you are under anesthesia. Dependent nurses, doctors, anesthesiologists have died like this with small doses of anesthetics. In fact, spontaneous breathing was there but the airway collapsed.

In short, I don't know what the cause of the nurse's death was, but respiratory arrest is definitely possible with this dose. However, if she was addicted to the drug, this would change the game. Cross tolerance.

Maybe the formula for CTB in this way can be "the upper limit of the therapeutic dose x 5" That is, 5gr. for 70 lbs. Still, much more case reports are needed. Sorry for english using google translate.

Edit: Don't forget you must find a way to keep thiopental in rectum when you go passed.

https://www.ajnr.org/content/ajnr/16/1/111.full.pdf

 

[Mayonaise]

Thank you very much for your detailed answer and don't worry, your English is very good.
I recall reading the paper you provided, but I'll have a more in-depth read very soon.

50mg/kg is the rectally administered anesthesia induction dose. So, 3500mg for an average of 70kg healthy person with no drug addiction. So this is the upper limit of the therapeutic dose.

The nurse weighed 135-lb / 60kgs so, according to what you said, the upper limit of the therapeutic dose for her should be 3000mg. Correct?

According to your attached case report, the nurse was exposed to 3.6 times the upper limit of therapeutic dose. Without any other drugs.

Why 3.6? She took 6500mg, so 6500 / 3000 = 2.16.
Not 3.6 times but 2.16, correct?

Back to the nurse, maybe she stopped breathing at some point, the hypercapnic reflex returned breathing but she could not protect the airway, just like in obstructive sleep apnea. The reflexes that would wake you up when the airway collapses in obstructive sleep apnea are still there. Not if you are under anesthesia. Dependent nurses, doctors, anesthesiologists have died like this with small doses of anesthetics. In fact, spontaneous breathing was there but the airway collapsed.

Let me get this straight: you are telling me that 1) She was anesthetized and stopped breathing because of that or 2) She was still breathing despite the drug but her airway collapsed for another reason.
Am I correct? Also, do you think the drug might be the reason behind airway collapse?

In short, I don't know what the cause of the nurse's death was, but respiratory arrest is definitely possible with this dose. However, if she was addicted to the drug, this would change the game. Cross tolerance.

Correct me if I'm wrong, but if she was addicted she would have needed more drug than a naive person. So, we may assume that a non-addict should need a lower dose than the one she took

Maybe the formula for CTB in this way can be "the upper limit of the therapeutic dose x 5" That is, 5gr. for 70 lbs.

Would you please explain the math behind this? I don't understand where "5gr. for 70 lbs" comes from.
Also, maybe you meant 70kgs, not 70lbs?

Edit: Don't forget you must find a way to keep thiopental in rectum when you go passed.

Agree, this must be investigated

This is a lot to read and answer to, I really appreciate your input.

 

[Sunset Limited]

"The nurse weighed 135-lb / 60kgs so, according to what you said, the upper limit of the therapeutic dose for her should be 3000mg. Correct?"

The 50mg/kg anesthesia induction dose is theoretical. We made it using the 25mg/kg procedural sedation induction dose in children as a reference, but the dose is reduced in adults. There is no way to calculate the actual adult anesthesia induction dose. The 1gr/70lbs upper therapeutic dose limit from the case report is more reliable. Calculate with this.





"Why 3.6? She took 6500mg, so 6500 / 3000 = 2.16.
Not 3.6 times but 2.16, correct?"

I answered this above. You must read case report. Calculate it with 1gr/70lbs.





"Let me get this straight: you are telling me that 1) She was anesthetized and stopped breathing because of that or 2) She was still breathing despite the drug but her airway collapsed for another reason.
Am I correct? Also, do you think the drug might be the reason behind airway collapse?"

Both scenarios are possible but respiratory arrest is more realistic. It was huge dose.






"Correct me if I'm wrong, but if she was addicted she would have needed more drug than a naive person. So, we may assume that a non-addict should need a lower dose than the one she took"

There is more factors. Age, weight, fat rate (obesity), chronical disease and don't forget this method has never used as a euthanasia procedure. All what we are saying still theoretical.







"Would you please explain the math behind this? I don't understand where "5gr. for 70 lbs" comes from.
Also, maybe you meant 70kgs, not 70lbs?"

Sorry it is1gr/75lbs. This is coming from your case report. "In the present case, the apparent rectal dose was 6.5 gm or approximately 3.6 gm/75 lb."

"3.6 gm/75 lb" According to this information, he weighed around 125lbs / 55-60kg. Since the therapeutic dose limit is 1gr/75lbs, the maximum dose for him is 1.8 grams. So 6.5 grams is 3.6 times of upper limit.

 

[Ugory]

Hey guys, may I cut in?
I have got 2 gr of decent street methadone.
I'm thinking of a better way of administration.
What comes to mind:
1. Oral. Bioavailability ranges from 36-90%. High risk of vomiting.
2. Intramuscular. There's a lot of discussion here. How painful it is (so much so that it could prevent the drug from being fully administered.). How much solution is acceptable to inject. And is it really worth injecting such a concentrated solution intramuscular? So much questions. It is believed that this will cause a chemical burn, which will probably interfere with the absorption of the solution.
3. IV system. Pretty complicated. The needle (catheter) may come out of the vein when you are unconscious.
4. Rectal. The one I'm considering. Simple, kind of reliably, probably painless. Most interested in what is the maximum volume allowed to be injected. The amount that will be absorbed.
That's all.
What do you think?

 

[Mayonaise]

"The nurse weighed 135-lb / 60kgs so, according to what you said, the upper limit of the therapeutic dose for her should be 3000mg. Correct?"

The 50mg/kg anesthesia induction dose is theoretical. We made it using the 25mg/kg procedural sedation induction dose in children as a reference, but the dose is reduced in adults. There is no way to calculate the actual adult anesthesia induction dose. The 1gr/70lbs upper therapeutic dose limit from the case report is more reliable. Calculate with this.





"Why 3.6? She took 6500mg, so 6500 / 3000 = 2.16.
Not 3.6 times but 2.16, correct?"

I answered this above. You must read case report. Calculate it with 1gr/70lbs.





"Let me get this straight: you are telling me that 1) She was anesthetized and stopped breathing because of that or 2) She was still breathing despite the drug but her airway collapsed for another reason.
Am I correct? Also, do you think the drug might be the reason behind airway collapse?"

Both scenarios are possible but respiratory arrest is more realistic. It was huge dose.






"Correct me if I'm wrong, but if she was addicted she would have needed more drug than a naive person. So, we may assume that a non-addict should need a lower dose than the one she took"

There is more factors. Age, weight, fat rate (obesity), chronical disease and don't forget this method has never used as a euthanasia procedure. All what we are saying still theoretical.







"Would you please explain the math behind this? I don't understand where "5gr. for 70 lbs" comes from.
Also, maybe you meant 70kgs, not 70lbs?"

Sorry it is1gr/75lbs. This is coming from your case report. "In the present case, the apparent rectal dose was 6.5 gm or approximately 3.6 gm/75 lb."

"3.6 gm/75 lb" According to this information, he weighed around 125lbs / 55-60kg. Since the therapeutic dose limit is 1gr/75lbs, the maximum dose for him is 1.8 grams. So 6.5 grams is 3.6 times of upper limit.

Thanks, everything's clear now. I have a final question though: according to you, will 10 or 20 gr of pure thio alone (without nitazenes or opioids) administered rectally be enough to ctb?
Could you give a % of reliability for 10 and 20 gr?
40yo male, no known physical illnesses, 75kg circa, height 1.75m

 

[FadingDawn]

also curious. do you have TH?

Thanks, everything's clear now. I have a final question though: according to you, will 10 or 20 gr of pure thio alone (without nitazenes or opioids) administered rectally be enough to ctb?
Could you give a % of reliability for 10 and 20 gr?
40yo male, no known physical illnesses, 75kg circa, height 1.75m

 

[Mayonaise]

also curious. do you have TH?

No, still researching

 

[FadingDawn]

No, still researching

one day, friend... one day maybe

 

[Sunset Limited]

Thanks, everything's clear now. I have a final question though: according to you, will 10 or 20 gr of pure thio alone (without nitazenes or opioids) administered rectally be enough to ctb?
Could you give a % of reliability for 10 and 20 gr?
40yo male, no known physical illnesses, 75kg circa, height 1.75m

I am sorry but don't forget case reports are not scientific studies. In scientific studies everything is clear. Case reports are gray. Rectal thiopental has never been a euthanasia protocol. 20 grams of rectal thiopental should be lethal for everyone, but there is no guarantee. 5 grams of thiopental IV provides a guarantee. 5 grams of thiopental was used as the sngle agent in executions in America. The prisoner died in 1.5 minutes. We have data. No data for rectal.

 

[Mayonaise]

I am sorry but don't forget case reports are not scientific studies. In scientific studies everything is clear. Case reports are gray. Rectal thiopental has never been a euthanasia protocol. 20 grams of rectal thiopental should be lethal for everyone, but there is no guarantee. 5 grams of thiopental IV provides a guarantee. 5 grams of thiopental was used as the sngle agent in executions in America. The prisoner died in 1.5 minutes. We have data. No data for rectal.

I got your point. Many thanks, you are extremely helpful. I hope you won't mind receiving some PM if I ever consider the IV route

 

[Mayonaise]

The OP, rotciv, posted a similar thread: https://sanctioned-suicide.net/threads/thiopental-and-other-barbiturates-used-rectally.127209

In his last post, he wrote: "I had a lot of work here but I came to the conclusion from my own experience that, given the pH of Thiopental, the rectal method is not good (you will have to go to the bathroom in an urgent manner)."
In the first post, he wrote that he planned to take 20g in a total of 20ml, and that the pH of the solution is 10.

@Sunset Limited , what do you think? Would 20ml of a solution with pH = 10 be really painful or uncomfortable in the rectum?