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SpecialK

SpecialK

Student
Apr 15, 2019
155
@Stan do you think 300mg of Quietiapine will do the job as antiemetic? I've read that they act as antiemetics.
 
Malletboy

Malletboy

Member
Nov 27, 2019
52
Would my Aripiprazole (Abilify) work as an atiemetic. I'm already taking it prescribed by my psychiatrist and have plenty of it. Apparently it's an atypical antipsychotic
 
BPD_LE

BPD_LE

The Queen of Meme
Aug 11, 2019
1,576
Would my Aripiprazole (Abilify) work as an atiemetic. I'm already taking it prescribed by my psychiatrist and have plenty of it. Apparently it's an atypical antipsychotic
No. You need a dopamine antagonist. Aripiprazole is a dopamine partial agonist.
 
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NeCkDeEp

NeCkDeEp

Experienced
Nov 30, 2019
285
Does anyone know or the SN on Amazon will be reliable?
I have found SN with the following information: NaNo2 0.6% will this be less reliable or?
I ordered yesterday SN on eBay but it will arrive on Friday which feels like ages away, however if the one on Amazon is reliable then I'm willing to use that one Monday bc the SN from Amazon will be here tomorrow if I'd order it
 
MeltingHeart

MeltingHeart

Visionary
Sep 9, 2019
2,151
Does anyone know or the SN on Amazon will be reliable?
I have found SN with the following information: NaNo2 0.6% will this be less reliable or?
I ordered yesterday SN on eBay but it will arrive on Friday which feels like ages away, however if the one on Amazon is reliable then I'm willing to use that one Monday bc the SN from Amazon will be here tomorrow if I'd order it
no,that is not the correct percentage,do not purchase that, it wont work.
 
NeCkDeEp

NeCkDeEp

Experienced
Nov 30, 2019
285
Okay thank you guys! I'll need to be patient until the SN from eBay arrives
 
Ksab

Ksab

Sorcerer
Dec 4, 2019
74
Does 90% pure laboratory grade SN works? It is the only grade and purity available near me.
 
NitriteAnatomy

NitriteAnatomy

Lost. Alone. Trapped. Need escape.
Nov 21, 2019
450
Does 90% pure laboratory grade SN works? It is the only grade and purity available near me.
It can, just need a bigger dose of it, since it's lower purity.
 
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nitrogen

nitrogen

Schrödinger's cat
Nov 5, 2019
339
You have specifically mentioned certain drugs in your antiemetic list. The Peaceful Pill eHandbook (as of March 2019) suggests alternatives like ondansetron that you have not mentioned. You also include some antiemetics that are not mentioned in that copy of the Peaceful Pill eHandbook.

(2) Why did you go with those particular antiemetics? I'm especially curious why you omitted ondansetron.
@Science Is Scary I was wondering about the same thing! I live in the U.S. and have Kaiser Permanente health insurance. It's my guess that the reason why PPH suggests ondansetron (Zofran) because it's probably the first line of treatment for nausea and vomiting in the US. PPH's contact address is listed in Washington state, US.

My entire family got moderate food poisoning last month, including my 2 y/o daughter. I called Kaiser - they have advisor nurses available on the phone 24/7, 365 days a year. After hearing my description of our symptoms, the advisor nurse got a physician to prescribe Zofran for the baby and myself. Mind you, the baby vomited eight times within a 2 hr timeframe. She projectile vomited EVERYTHING we fed her through both mouth and nose, couldn't even hold water down. Because she didn't vomit bile or blood, did not run a fever, the nurse didn't think it was serious enough to bring her into the ER. It's really easy to get an Rx for Zofran in the US.

I know Stan replied to this question of yours saying "Ondansetron, looking at this I could see no detail saying it dealt with the right type of the brain for this. If you can I would be happy to include it." I mean I read this 10 times and I don't understand what he meant.

Do you have this figured out yet? Does anybody know what excuse to use to get Rx for metoclopramide in the US? If it's easy to get Rx for meto, is meto still more ideal than Zofran?
 
Last edited:
Science Is Scary

Science Is Scary

Evidence is the path to the truth. Maybe.
Oct 17, 2019
87
I haven't really learned much more about antiemetics than what I posted, @nitrogen. I'm still very confused.

Using NICE Evidence Search, I found an article that outlines different mechanisms of persistent nausea and vomiting. Those various mechanisms may be what Stan was referring to. I haven't done enough research to say which mechanism seems appropriate for sodium nitrite poisoning. The mechanism might suggest which antiemetics are most appropriate.

You may be able to look up various evidence-based treatment guides on NICE Evidence Search and the FDA Labels for Metoclopramide to see when one antiemetic might be prescribed over another.

If you find anything interesting, I'd love to hear about it.

Thanks for your interest.
 
sleepy dog

sleepy dog

Wizard
Sep 13, 2019
624
I you go to this link and click on TARGETS, the page will scroll to that section. Nowhere in that section does it say "dopamine receptor". I think that's what it needs to target to be an anti-emetic. But I am not a doctor, biologist, or chemist.

https://www.drugbank.ca/drugs/DB00904
 
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I

Ineedtobedead

Member
Nov 11, 2019
45
I'm using ranittidine as antacid but I read that it reaches its highest blood concentration 1~3h after taken orally, so I'm kinda worried if it'll be able to do its thing if it's taken only 30 minutes before SN?
 
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BPD_LE

BPD_LE

The Queen of Meme
Aug 11, 2019
1,576
@Science Is Scary I was wondering about the same thing! I live in the U.S. and have Kaiser Permanente health insurance. It's my guess that the reason why PPH suggests ondansetron (Zofran) because it's probably the first line of treatment for nausea and vomiting in the US. PPH's contact address is listed in Washington state, US.

My entire family got moderate food poisoning last month, including my 2 y/o daughter. I called Kaiser - they have advisor nurses available on the phone 24/7, 365 days a year. After hearing my description of our symptoms, the advisor nurse got a physician to prescribe Zofran for the baby and myself. Mind you, the baby vomited eight times within a 2 hr timeframe. She projectile vomited EVERYTHING we fed her through both mouth and nose, couldn't even hold water down. Because she didn't vomit bile or blood, did not run a fever, the nurse didn't think it was serious enough to bring her into the ER. It's really easy to get an Rx for Zofran in the US.

I know Stan replied to this question of yours saying "Ondansetron, looking at this I could see no detail saying it dealt with the right type of the brain for this. If you can I would be happy to include it." I mean I read this 10 times and I don't understand what he meant.

Do you have this figured out yet? Does anybody know what excuse to use to get Rx for metoclopramide in the US? If it's easy to get Rx for meto, is meto still more ideal than Zofran?
Zofran has a low affinity to dopamine. The effective antiemetics for SN are dopamine antagonists/blockers like meto.
I'm using ranittidine as antacid but I read that it reaches its highest blood concentration 1~3h after taken orally, so I'm kinda worried if it'll be able to do its thing if it's taken only 30 minutes before SN?
Ranitidine is a H2 Blocker which prevents the stomach from producing acid. H2 Blockers can start working within 30mins but you are correct when you say the optimal effects can take up to 3 hours. You may want to look into taking a simple OTC antacid instead as it's faster acting.
 
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sleepy dog

sleepy dog

Wizard
Sep 13, 2019
624
I'm using ranittidine as antacid but I read that it reaches its highest blood concentration 1~3h after taken orally, so I'm kinda worried if it'll be able to do its thing if it's taken only 30 minutes before SN?

Where did you get that information? I want to look up some other drugs for the same data.
 
I

Ineedtobedead

Member
Nov 11, 2019
45
Where did you get that information? I want to look up some other drugs for the same data.
I found the information on baidubaike which is kinda like a Chinese version of wikipedia.. it's easier for me to read since I'm Chinese
 
I

Ineedtobedead

Member
Nov 11, 2019
45
I think that is the half-life time, but not sure.
It says the half-life time is 2~3h in the pharmacokinetics(药代动力学) part
 
Last edited:
Victory

Victory

Member
Dec 11, 2019
11
please tell me from which country can I order sn food (<95%) with delivery to Belarus?
 
nitrogen

nitrogen

Schrödinger's cat
Nov 5, 2019
339
Greetings mathafakas,

So I read this entire thread once, did some research and lied to my doctor (successfully, muahaha),
Screen Shot 2019 12 11 at 63323 PM
Here are some results:

Besides taking antacids, there's more you can do to minimize the amount of HCl present in your stomach when you ingest SN - looks like nobody has mentioned it on this thread:

Avoid an environment with exposure to the sight and smell of food; don't even think about food, don't chew gum. As much as 30-50% of the total postprandial gastric acid secretions produced is stimulated by anticipation of eating, the smell or taste of food, the acts of eating (chewing and swallowing) during the cephalic phase of gastric acid secretion [1]. Signaling of this process is involuntary, so you can't control it with your mind or will [1].

Fast and use only enough water that allows SN to completely dissolve. About 60% of the total acid for a meal is produced during the gastric phase [5]. The acid secretion is stimulated by distension of the stomach and amino acids present in food [2]. The remaining 10% of gastric acid is secreted when chyme (the semi-fluid mixture of partly digested food and gastric juice) enters the upper portion of the small intestines during the intestinal phase [5][2]. If your living situation doesn't allow you to fast, avoid foods rich in protein, caffeine, etc [3].

Here's a helpful diagram on what stimulates and what inhibits gastric juice secretion:
Three Phases Gastric Secretion


However, even if you're fasting and manage to stay away from the sight, smell, thought and the act of eating food, there's still a small continuous basal secretion of gastric acid [4].

If being found and interrupted isn't a concern, I actually think doing the stat dose first thing in the morning is better than taking it at midnight as Stan suggested. Fasting for 8 hours during your sleep is a piece of cake; whereas fasting during the day when you're awake is unpleasant and would make your stomach extra sensitive to the stimulation of the thoughts, smell, sight of food [16]. In addition, when people fast for an extended period of time, like during the two-day regimen or fast throughout the entire day, many people already feel nauseated from hunger, compounded with ingestion of SN will just make them even more nauseated due to HCl buildup in the stomach and chemical balancing act of the "hunger hormones" in the body gets thrown out of whack [15]. FYI, if the hunger signals aren't ignored for too long, the hunger hormones (leptin & ghrelin) stay in balance [15].

I wish Stan is still around to compare notes with me and let me pick his brain. May he rest in peace.

ONDANSETRON VS METOCLOPRAMIDE
Ondansetron and metoclopramide belong to different drug classes. Ondansetron is an anti-nausea medication and metoclopramide is a prokinetic medication, although both have antiemetic effects through different mechanisms [6].

Ondansetron, a serotonin 5-HT3 receptor antagonist that blocks the effects of serotonin in both the brain and gastrointestinal tract to reduce nausea and vomiting [7][10].

Metoproclamide as a prokinetic agent, interacts with acetylcholine and dopamine receptors on gastrointestinal muscles and nerves to improve the muscle action - strengthens the lower esophageal sphincter (prevent stomach content from flowing up thus antiemetic) and increase stomach muscle contraction (speeds up emptying stomach content into intestines thus prokinetic) [8][9]. Meto can considerably speed up intestinal absorption of certain orally administered drugs, perhaps can make SN work quickly and reduce the amount of SN being broken down by stomach acid [11][12].

My research suggests that Ondansetron (Zofran) causes fewer and milder side effects (mostly just headache, fatigue, constipation and diarrhea) than meto. Metoproclamide, on the other hand, can cause serious neurological symptoms although one time use or short term use will unlikely trigger them [6]. Ondansetron is indicated for the pediatric population but metoproclamide is not - another indicator that ondansetron is safer in terms of side effects [14].

I just got my hands on the Peaceful Pill eHandbook March 2019 version through this thread:
https://sanctioned-suicide.net/threads/the-peaceful-pill-ehandbook-march-24-2019-revision.14416/
Big thanks to @HelensNepenthe for sharing the PPH. Also, this is her 3rd post of her thread, about PPH's last several revisions on SN.
Screen Shot 2019 12 11 at 123703 PM
Screen Shot 2019 12 11 at 123718 PM
Screen Shot 2019 12 11 at 123735 PM

The earlier versions say vomiting is unlikely, then the latest March 2019 version says it's possible. I suppose that means vomiting isn't a huge concern for most ppl who choose this method.

@Science Is Scary Where did you see the PPH suggests ondansetron? I only see it suggests meto (I haven't read through the entire book, only the SN section from page 149-157).

A NOTE ON PAIN KILLER
When it comes to choosing a pain killer, avoid the opioids category, such as oxycodone - looks like nobody has mentioned it on this thread - opioids dramatically slow down gastric emptying, which means SN sits in the stomach longer, more SN gets broken down by gastric acid, absorption of SN through small intestine is delayed and takes longer to die [13].

STORIES USED TO SUCCESSFUL OBTAIN METO RX IN THE USA
I lied to my doc today and she prescribed me metoclopramide, here's a screenshot of the correspondence for your reference. PS, neither my husband nor myself took meto before - it's a lie:
Screen Shot 2019 12 11 at 64853 PM

Screen Shot 2019 12 11 at 65018 PM
So yeah, meto is super easy to get in the US. Just shoot an email or call your doc. No office or ER visit required, no lab tests required.

STORIES USED TO SUCCESSFUL OBTAIN ONDANSETRON RX IN THE USA
Food poisoning - say you're vomiting and can't keep food down; but alert, no fever, not vomiting blood or bile. Again, Rx is super easy to get. Just email or call your doc. No need for office or ER visits. I know if you Google ondansetron (Zofran) online and the internet will only say it's indicated for nausea and vomiting caused by chemotherapy (cancer drug treatment) and after surgery, but it's definitely the first line of treatment for food poisoning without serious alarming symptoms - I can tell you that from personal experience.

@passenger27 Your avatar makes me nauseated and gives me a headache. I bet it can trigger photosensitive epilepsy in some people.

@Ineedtobedead 中国现在好像很流行喝百草枯, 没几个人知道SN哎。

References:

[1] https://www.sciencedirect.com/topics/medicine-and-dentistry/cephalic-phase

[2] https://opentextbc.ca/anatomyandphysiology/chapter/23-4-the-stomach/

[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544304/

[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC424132/

[5] https://www.clinicaleducation.org/resources/reviews/the-role-of-hcl-in-gastric-function-and-health/

[6]https://www.medicinenet.com/ondanse...ide_effects_of_ondansetron_and_metoclopramide

[7] https://link.springer.com/article/10.2165/00023210-199708050-00005

[8] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699728/

[9] https://www.medicinenet.com/metoclopramide/article.htm

[10]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426995/

[11] https://www.ncbi.nlm.nih.gov/pubmed/11958284

[12] https://www.ncbi.nlm.nih.gov/pubmed/7882635

[13] https://www.mayoclinic.org/diseases-conditions/gastroparesis/symptoms-causes/syc-20355787

[14] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3cc8ca5b-8b71-4c77-a181-9ce154597b9a

[15] https://www.livescience.com/why-nauseous-when-hungry.html

[16] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2297467/
 
Last edited:
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Jean4

Jean4

Remember. I am ALWAYS right.... until I’m not
Apr 28, 2019
7,558
Greetings mathafakas,

So I read this entire thread once, did some research and lied to my doctor (successfully, muahaha),
View attachment 21098
Here are some results:

Besides taking antacids, there's more you can do to minimize the amount of HCl present in your stomach when you ingest SN - looks like nobody has mentioned it on this thread:

Avoid an environment with exposure to the sight and smell of food; don't even think about food, don't chew gum. As much as 30-50% of the total postprandial gastric acid secretions produced is stimulated by anticipation of eating, the smell or taste of food, the acts of eating (chewing and swallowing) during the cephalic phase of gastric acid secretion [1]. Signaling of this process is involuntary, so you can't control it with your mind or will [1].

Fast and use only enough water that allows SN to completely dissolve. About 60% of the total acid for a meal is produced during the gastric phase [5]. The acid secretion is stimulated by distension of the stomach and amino acids present in food [2]. The remaining 10% of gastric acid is secreted when chyme (the semi-fluid mixture of partly digested food and gastric juice) enters the upper portion of the small intestines during the intestinal phase [5][2]. If your living situation doesn't allow you to fast, avoid foods rich in protein, caffeine, etc [3].

Here's a helpful diagram on what stimulates and what inhibits gastric juice secretion:
View attachment 21086


However, even if you're fasting and manage to stay away from the sight, smell, thought and the act of eating food, there's still a small continuous basal secretion of gastric acid [4].

If being found and interrupted isn't a concern, I actually think doing the stat dose first thing in the morning is better than taking it at midnight as Stan suggested. Fasting for 8 hours during your sleep is a piece of cake; whereas fasting during the day when you're awake is unpleasant and would make your stomach extra sensitive to the stimulation of the thoughts, smell, sight of food [16]. In addition, when you fast for an extended period of time, like during the 48 hr regime or fasting throughout the day, many people already feel nauseated from the hunger, compounded with ingestion of SN will just make them even more nauseated due to HCl buildup in the stomach and chemical balancing act of the "hunger hormones" in the body gets thrown out of whack [15].

I wish Stan is still around to compare notes with me and let me pick his brain. May he rest in peace.

ONDANSETRON VS METOCLOPRAMIDE
Ondansetron and metoclopramide belong to different drug classes. Ondansetron is an anti-nausea medication and metoclopramide is a prokinetic medication, although both have antiemetic effects through different mechanisms [6].

Ondansetron, a serotonin 5-HT3 receptor antagonist that blocks the effects of serotonin in both the brain and gastrointestinal tract to reduce nausea and vomiting [7][10].

Metoproclamide as a prokinetic agent, interacts with acetylcholine and dopamine receptors on gastrointestinal muscles and nerves to improve the muscle action - strengthens the lower esophageal sphincter (prevent stomach content from flowing up thus antiemetic) and increase stomach muscle contraction (speeds up emptying stomach content into intestines thus prokinetic) [8][9]. Meto can considerably speed up intestinal absorption of certain orally administered drugs, perhaps can make SN work quickly and reduce the amount of SN being broken down by stomach acid [11][12].

My research suggests that Ondansetron (Zofran) causes fewer and milder side effects (mostly just headache, fatigue, constipation and diarrhea) than meto. Metoproclamide, on the other hand, can cause serious neurological symptoms although one time use or short term use will unlikely trigger them [6]. Ondansetron is indicated for the pediatric population but metoproclamide is not - another indicator that ondansetron is safer in terms of side effects [14].

I just got my hands on the Peaceful Pill eHandbook March 2019 version through this thread:
https://sanctioned-suicide.net/threads/the-peaceful-pill-ehandbook-march-24-2019-revision.14416/
Big thanks to @HelensNepenthe for sharing the PPH. Also, this is her 3rd post of her thread, about PPH's last several revisions on SN.
View attachment 21092
View attachment 21093
View attachment 21094

The earlier versions say vomiting is unlikely, then the latest March 2019 version says it's possible. I suppose that means vomiting isn't a huge concern for most ppl who choose this method.

@Science Is Scary Where did you see the PPH suggests ondansetron? I only see it suggests meto (I haven't read through the entire book, only the SN section from page 149-157).

A NOTE ON PAIN KILLER
When it comes to choosing a pain killer, avoid the opioids category, such as oxycodone - looks like nobody has mentioned it on this thread - opioids dramatically slow down gastric emptying, which means SN sits in the stomach longer, more SN gets broken down by gastric acid, absorption of SN through small intestine is delayed and takes longer to die [13].

STORIES USED TO SUCCESSFUL OBTAIN METO RX IN THE USA
I lied to my doc today and she prescribed me metoclopramide, here's a screenshot of the correspondence for your reference. PS, neither my husband nor myself took meto before - it's a lie:
View attachment 21096

View attachment 21097
So yeah, meto is super easy to get in the US. Just shoot an email or call your doc. No office or ER visit required, no lab tests required.

STORIES USED TO SUCCESSFUL OBTAIN ONDANSETRON RX IN THE USA
Food poisoning - vomiting and can't keep food down; but alert, no fever, not vomiting blood or bile.

@passenger27 Your avatar makes me nauseated and gives me a headache. I bet it can trigger photosensitive epilepsy in some people.

@Ineedtobedead 中国现在好像很流行喝百草枯, 没几个人知道SN哎。

References:

[1] https://www.sciencedirect.com/topics/medicine-and-dentistry/cephalic-phase

[2] https://opentextbc.ca/anatomyandphysiology/chapter/23-4-the-stomach/

[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544304/

[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC424132/

[5] https://www.clinicaleducation.org/resources/reviews/the-role-of-hcl-in-gastric-function-and-health/

[6]https://www.medicinenet.com/ondanse...ide_effects_of_ondansetron_and_metoclopramide

[7] https://link.springer.com/article/10.2165/00023210-199708050-00005

[8] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699728/

[9] https://www.medicinenet.com/metoclopramide/article.htm

[10]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426995/

[11] https://www.ncbi.nlm.nih.gov/pubmed/11958284

[12] https://www.ncbi.nlm.nih.gov/pubmed/7882635

[13] https://www.mayoclinic.org/diseases-conditions/gastroparesis/symptoms-causes/syc-20355787

[14] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3cc8ca5b-8b71-4c77-a181-9ce154597b9a

[15] https://www.livescience.com/why-nauseous-when-hungry.html

[16] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2297467/
You did a great job. Stan would be proud.
 
passenger27

passenger27

In my beginning is my end.
Aug 25, 2019
642
Greetings mathafakas,

So I read this entire thread once, did some research and lied to my doctor (successfully, muahaha),
View attachment 21098
Here are some results:

Besides taking antacids, there's more you can do to minimize the amount of HCl present in your stomach when you ingest SN - looks like nobody has mentioned it on this thread:

Avoid an environment with exposure to the sight and smell of food; don't even think about food, don't chew gum. As much as 30-50% of the total postprandial gastric acid secretions produced is stimulated by anticipation of eating, the smell or taste of food, the acts of eating (chewing and swallowing) during the cephalic phase of gastric acid secretion [1]. Signaling of this process is involuntary, so you can't control it with your mind or will [1].

Fast and use only enough water that allows SN to completely dissolve. About 60% of the total acid for a meal is produced during the gastric phase [5]. The acid secretion is stimulated by distension of the stomach and amino acids present in food [2]. The remaining 10% of gastric acid is secreted when chyme (the semi-fluid mixture of partly digested food and gastric juice) enters the upper portion of the small intestines during the intestinal phase [5][2]. If your living situation doesn't allow you to fast, avoid foods rich in protein, caffeine, etc [3].

Here's a helpful diagram on what stimulates and what inhibits gastric juice secretion:
View attachment 21086


However, even if you're fasting and manage to stay away from the sight, smell, thought and the act of eating food, there's still a small continuous basal secretion of gastric acid [4].

If being found and interrupted isn't a concern, I actually think doing the stat dose first thing in the morning is better than taking it at midnight as Stan suggested. Fasting for 8 hours during your sleep is a piece of cake; whereas fasting during the day when you're awake is unpleasant and would make your stomach extra sensitive to the stimulation of the thoughts, smell, sight of food [16]. In addition, when people fast for an extended period of time, like during the two-day regimen or fast throughout the entire day, many people already feel nauseated from hunger, compounded with ingestion of SN will just make them even more nauseated due to HCl buildup in the stomach and chemical balancing act of the "hunger hormones" in the body gets thrown out of whack [15]. FYI, if the hunger signals aren't ignored for too long, the hunger hormones (leptin & ghrelin) stay in balance [15].

I wish Stan is still around to compare notes with me and let me pick his brain. May he rest in peace.

ONDANSETRON VS METOCLOPRAMIDE
Ondansetron and metoclopramide belong to different drug classes. Ondansetron is an anti-nausea medication and metoclopramide is a prokinetic medication, although both have antiemetic effects through different mechanisms [6].

Ondansetron, a serotonin 5-HT3 receptor antagonist that blocks the effects of serotonin in both the brain and gastrointestinal tract to reduce nausea and vomiting [7][10].

Metoproclamide as a prokinetic agent, interacts with acetylcholine and dopamine receptors on gastrointestinal muscles and nerves to improve the muscle action - strengthens the lower esophageal sphincter (prevent stomach content from flowing up thus antiemetic) and increase stomach muscle contraction (speeds up emptying stomach content into intestines thus prokinetic) [8][9]. Meto can considerably speed up intestinal absorption of certain orally administered drugs, perhaps can make SN work quickly and reduce the amount of SN being broken down by stomach acid [11][12].

My research suggests that Ondansetron (Zofran) causes fewer and milder side effects (mostly just headache, fatigue, constipation and diarrhea) than meto. Metoproclamide, on the other hand, can cause serious neurological symptoms although one time use or short term use will unlikely trigger them [6]. Ondansetron is indicated for the pediatric population but metoproclamide is not - another indicator that ondansetron is safer in terms of side effects [14].

I just got my hands on the Peaceful Pill eHandbook March 2019 version through this thread:
https://sanctioned-suicide.net/threads/the-peaceful-pill-ehandbook-march-24-2019-revision.14416/
Big thanks to @HelensNepenthe for sharing the PPH. Also, this is her 3rd post of her thread, about PPH's last several revisions on SN.
View attachment 21092
View attachment 21093
View attachment 21094

The earlier versions say vomiting is unlikely, then the latest March 2019 version says it's possible. I suppose that means vomiting isn't a huge concern for most ppl who choose this method.

@Science Is Scary Where did you see the PPH suggests ondansetron? I only see it suggests meto (I haven't read through the entire book, only the SN section from page 149-157).

A NOTE ON PAIN KILLER
When it comes to choosing a pain killer, avoid the opioids category, such as oxycodone - looks like nobody has mentioned it on this thread - opioids dramatically slow down gastric emptying, which means SN sits in the stomach longer, more SN gets broken down by gastric acid, absorption of SN through small intestine is delayed and takes longer to die [13].

STORIES USED TO SUCCESSFUL OBTAIN METO RX IN THE USA
I lied to my doc today and she prescribed me metoclopramide, here's a screenshot of the correspondence for your reference. PS, neither my husband nor myself took meto before - it's a lie:
View attachment 21096

View attachment 21097
So yeah, meto is super easy to get in the US. Just shoot an email or call your doc. No office or ER visit required, no lab tests required.

STORIES USED TO SUCCESSFUL OBTAIN ONDANSETRON RX IN THE USA
Food poisoning - say you're vomiting and can't keep food down; but alert, no fever, not vomiting blood or bile. Again, Rx is super easy to get. Just email or call your doc. No need for office or ER visits. I know if you Google ondansetron (Zofran) online and the internet will only say it's indicated for nausea and vomiting caused by chemotherapy (cancer drug treatment) and after surgery, but it's definitely the first line of treatment for food poisoning without serious alarming symptoms - I can tell you that from personal experience.

@passenger27 Your avatar makes me nauseated and gives me a headache. I bet it can trigger photosensitive epilepsy in some people.

@Ineedtobedead 中国现在好像很流行喝百草枯, 没几个人知道SN哎。

References:

[1] https://www.sciencedirect.com/topics/medicine-and-dentistry/cephalic-phase

[2] https://opentextbc.ca/anatomyandphysiology/chapter/23-4-the-stomach/

[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544304/

[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC424132/

[5] https://www.clinicaleducation.org/resources/reviews/the-role-of-hcl-in-gastric-function-and-health/

[6]https://www.medicinenet.com/ondanse...ide_effects_of_ondansetron_and_metoclopramide

[7] https://link.springer.com/article/10.2165/00023210-199708050-00005

[8] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699728/

[9] https://www.medicinenet.com/metoclopramide/article.htm

[10]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426995/

[11] https://www.ncbi.nlm.nih.gov/pubmed/11958284

[12] https://www.ncbi.nlm.nih.gov/pubmed/7882635

[13] https://www.mayoclinic.org/diseases-conditions/gastroparesis/symptoms-causes/syc-20355787

[14] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3cc8ca5b-8b71-4c77-a181-9ce154597b9a

[15] https://www.livescience.com/why-nauseous-when-hungry.html

[16] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2297467/
Wow. Thanks!
 
nitrogen

nitrogen

Schrödinger's cat
Nov 5, 2019
339
There's more you can do to increase SN success rate - nobody has mentioned on this thread:
Start to take phytic acid supplement or eat a copious amount of almonds one week before you take your SN drink. Basically, phytic acid prevents methemoglobin from being converted back into hemoglobin - you want methemoglobin for SN method to work.
@deathbyginger did a marvelous job at explaining this in detail, so I won't be redundant here. This is the link to her thread if you want to learn more https://sanctioned-suicide.net/threads/1-week-dietary-supplement-regimen-sn.25744/

Phytic acid is mentioned in one of Dr. Nitschke's Vimeo videos. You can find the video on post #99 of the SN mega thread posted by one amazing SS member @mattwitt . Here's the link https://sanctioned-suicide.net/threads/sn-megathread.1156/page-4

I picked up my meto from the pharmacy yesterday. My doc prescribed 60 10mg tablets, no refills. That's enough for 20 attempts with the stat dose regimen, lol. Here're the pics:
Screen Shot 2019 12 13 at 13915 PM

Screen Shot 2019 12 13 at 14234 PM

@Ark I just want to say you're a virtuous human being and I'm very fond of you. When my psychopathic tendencies take over me, your posts fill my heart with warmth. I go from this:
Giphy
To this:
IMG 3416
So thank you and I truly enjoy reading your posts.
 
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A

Ark

Arcanist
Oct 18, 2019
412
@nitrogen
Thank you for the kind words. I do my best to try to help everyone I can, however I can in their situation. I am afraid my honesty will upset people sometimes but, I try my best.

Also, nice post. Very informative and your research was obviously extensive. I also greatly enjoy reading your posts.
 
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Jean4

Jean4

Remember. I am ALWAYS right.... until I’m not
Apr 28, 2019
7,558
@nitrogen
Thank you for the kind words. I do my best to try to help everyone I can, however I can in their situation. I am afraid my honesty will upset people sometimes but, I try my best.

Also, nice post. Very informative and your research was obviously extensive. I also greatly enjoy reading your posts.
Never stop being honest. NEVER. ;)
 
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Skyview

Skyview

Going Blue
Dec 9, 2019
473
Today my SN arrived , naNo2 (Anhydrous) 99.6% (8oz, 227grams x2) Now I just need to source the other components and have been reading the resource thread by Stan .
 
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Science Is Scary

Science Is Scary

Evidence is the path to the truth. Maybe.
Oct 17, 2019
87
I really appreciate you sharing your research, @nitrogen! You did great work.

Ondansetron is mentioned as an alternative in the Drugs and Vomiting section starting around page 180 of the March 2019 Peaceful Pill Handbook. That section talks about drugs and vomiting in general and not specifically sodium nitrite. It may or may not be relevant.
 
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Solo

Solo

Member
Mar 28, 2019
57
where do i buy sn since the ones on amazon and ebay only ship to us
 
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