Not any old antacid. Proton pump inhibitors are supposed to be avoided. Can't remember why, but it's definitely in these pages somewhere. Maybe a post from the much missed @jake3d
"
Nitrite reduced systolic blood pressure by a maximum of 6±1.3 mm Hg when taken after placebo, whereas pretreatment with esomeprazole [a PPI] blunted this effect...
We conclude that the acute blood pressure–lowering effect of nitrite requires an acidic gastric environment."
"PPIs increase blood pressure"
"Direct administration of nitrite to humans or animals has demonstrated many similar effects as nitrate, including protection against ischemia–reperfusion injury and vasodilatory, antihypertensive, and metabolic effects."
"Pretreatment with esomeprazole did not significantly alter blood pressure measured before intake of sodium nitrite."
"
Nitrite ingestion resulted in an acute lowering effect of systolic blood pressure when taken after pretreatment with placebo. The drop was maximal at 15 minutes after nitrite ingestion and gradually returned to basal values during the 2-hour observation period.
In contrast, when the volunteers instead were pretreated with esomeprazole, sodium nitrite induced no significant change in systolic blood pressure. At the dose used, sodium nitrite induced no significant changes in diastolic blood pressure with either of the 2 pretreatments."
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The type II histamine receptor antagonists, cimetidine and ranitidine, widely used in treatment of peptic ulcer disease have been reported to cause bradycardia. To evaluate the cardiovascular effects of H2 antagonists nineteen healthy volunteers were entered into a double-blind crossover...
www.ncbi.nlm.nih.gov
"The type II histamine receptor antagonists, cimetidine and ranitidine, widely used in treatment of peptic ulcer disease have been reported to cause bradycardia... in 5 subjects, the heart rate at 25% maximum VO2 was depressed 8% (P less than or equal to 0.03)."
• Incidence and mechanisms of cimetidine-induced hypotension were investigated during the first intravenous injection of cimetidine (200 mg over three minutes) in 68 consecutive patients in the intensive care unit. Systolic pressure decreased more than 5 mm Hg (average, 14 mm Hg) in 50 patients,...
jamanetwork.com
"Blood pressure decreased significantly more in patients requiring vasoconstrictor drug support. The arterial vasodilator properties of cimetidine were demonstrated in 12 normal volunteers in whom brachial artery cimetidine infusions caused a significant decrease of forearm vascular resistance."
(intravenous administration)
www.ncbi.nlm.nih.gov
"Ondansetron [an antiemetic] and ranitidine both can cause bradycardia and cardiac arrest"
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So even if H2Bs raise gastric PH, shouldn't be a big deal, as long as stomach is empty... I think ("W
e conclude that the acute blood pressure–lowering effect of nitrite requires an acidic gastric environment.")
TBH This is weird because histamine antagonist should counter histamine effects, i.e. vasodilation. I understand that works when H1Bs and H2Bs are used in combination
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In sum:
PPIs raise blood pressure, while Nitrite lowers it. PPIs blunt Nitrite's effects.
H2Bs blockers (Cimetidine, Rinatidine) lower blood pressure, according to some sources (including when taken with an antiemetic, judging by that one study)
I suppose this goes against
@Stan who pointed out that when you ingest poison voluntarily you want the blood to pump faster, not the other way around.