Method Prochlorperazine dosage

[arcadia]

I've got Prochlorperazine as my AE, but I'm wondering what the dosage would be before taking SN.

 

[HerculePoirot]

Prochlorperazine Dosage Guide + Max Dose, Adjustments - Drugs.com

Detailed Prochlorperazine dosage information for adults and children. Includes dosages for Anxiety, Nausea/Vomiting, Schizophrenia and more; plus renal, liver and dialysis adjustments.

www.drugs.com

 

[dimstar]

Hey sorry to bump an old thread but this my AE too. I was planning 30mg stat dose. This guide says 40 max but I saw a FAQ guide that to take a smaller dose of Prochlorperazine 10-20mg. Anyone have input?
Not an old thread lol sorry. Cheers whoops

Hi,
Rough draft – please suggest information, links, changes. Aimed at 95% of target audience (FAQ shouldnt address exceptional cases/patients). Written for myself over 3 months , pasted with little proof-reading. Any harmful, inciting, or misleading info here should be removed. So let me know.
Q

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Disclaimer & Information​

Is this a guide?	NO. Goal – clarify frequent questions , provide links to read Most had been addressed in the guide or thread. First read Stan's Guide and Stan's thread Almost nothing here is new
How to find MEDICATION X ?​ Can I use MEDICAION Y ?	Can't answer that.​ There are literally 100s of brands(!) of AE, antacids, benzo, painkillers.​ You must search brand and compare ingredients.​
Should I trust this FAQ?	NO. Many things are common knowledge/practices. This is not scientific, do research.

SUMMARY​

	Function​	Hard to get​	How often used with SN (very rough estimate)​
Better SN intake​
Antiemetics (AE)	Stomach emptying, anti-vomiting	Yes	70%
Antacid / Acid-Reducers	May improve absorption	No	80%
Ease symptoms​
Painkillers (NSAID)	Headache, pain	No	90%
Benzo / Sedatives	Anxiety, pain, induce sleep	Partially	70%
Beta Blockers	Strong/fast heartbeat	Partially	40%

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Antiemetics (AE)​
What they do:	Move SN quick to intestine – fatal Reduce vomiting​
Do I need it?	No, but recommended. Many used SN fatally without AE Many vomited even with AE Could go either way. No definitive answer.
Are they available?	NO. Prescription only. Ask physician, example (original post) Search Internet Consult existing threads (others looking for it) Notes – Acquiring or importing prescription-only medication without a prescription is illegal. Antiemetics are not "restricted substance" but if caught may be fined (investigation unlikely). Forging prescription is a serious crime.
Warnings:	CAUTION. Meto & Prochlorperazine may cause problems. Must check contraindication to existing meds. Test small dosage (5mg) well before your ctb: Mild effects – try another small dose 8h later, or with painkillers (tolerance: less side effects) Severe effects – avoid.
Will any antiemetic work?	NO. Guide provides 6 AEs – only use those. Antiemetics: Must target dopamine (Domperidone, Prochlorperazine) Preferably serotonin as well (Metoclopramide)
Common antiemetics – short review	Prochlorperazine – ✓strongest dopamine blocker , no quick stomach emptying , high EPS risk Metoclopramide – ✓strong dopamine blocker , ✓ quick stomach emptying , moderate EPS risk Domperidone – ✓good dopamine blocker , ✓ quick stomach emptying , little EPS risk Domperidone is efficient as Metoclopramide for anti-vomiting (research)
Will X work as AE?​	If not in guide and you've searched threads, then NO. Don't use as antiemetics – Ondansetron/Zofran Diphenhydramine/Benadryl Dimenhydrinate/Dramamine Serotonin or Histamine only are not as effective. They don't promote gastric emptying. Read guide (AE by type – need dopamine antagonist)
What are "The 13 Antipsychotics"?	Replace AE completely – ONLY if part of your regular health treatment. Do not take a single dose; Do not change prescribed dosage. Personally-tailored – dosage varies greatly between individuals (explained here & here) If used regularly they replace AE – use Stat directions (without meto). Stan listed meds with nM (receptor affinity). Higher numbers may indicate stronger effects. Example .
Antiemetics – "Meto"​
Warnings:	Many are fine with it; some aren't; for a few poses a risk. Contraindications – SSRI, SNRI, TCAs, many anti-psychotics, and more. EPS effects – muscle spasms, jerky movements, tremors. EPS effects relieved with Diphenhydramine/Benadryl Members reported other effects(non EPS): "extreme unease in body, driving me crazy" "made me feel very ill, my whole body" "after taking meto went to sleep 4 hour" "throbbing headache"
Note – Prochlorperazine	Not Meto, but same warnings apply. Prochlorperazine has higher EPS risk
Why Meto preferred?	Only antiemetic that: Targets both dopamine and 5HT3, and Crosses into the brain This means: Strong stomach emptying effect Strong anti-vomiting vomiting effect However read "Do I need it"; alternatives (5) are fine.
Can strong effect achieved without Meto?	Ondansetron and Domperidone target peripheral receptors, not the brain (less side effects): Domperidone (Dopamine, less EPS) + Ondansetron (5HT3, less EPS) = Metoclopramide (Dopamine+5HT3 , Brain/EPS)
Bad Meto reaction – what to do?	Take Diphenhydramine/Benadryl 'Failing Meto' is fine, may: Use any of the other 5 on the list, or Ctb without antiemetics (many have but follow guide)
Antiemetics - Stat/Regimen​
What is it?	"Regimen/State" refers only to antiemetics. Two ways to take antiemetics: One single dose – Stat or Over 24h-48h – Regimen This may apply to N (consult guides).
Stat or Regimen?​	Both used with equal success. Depends on your sensitivities, conditions, and preferences.
Regimen –	Builds tolerance – reduces side-effects Increased effectiveness – accumulates (also) – increased stomach tone over time Comfortable – structured, feel prepared for ctb
Stat –	Efficacy appears similar with less hassle (no schedule) Less worry – like side effects during 2 days Comfortable – not demanding, no anxious wait, quick & simple
So, which should I choose?	Really up to you. Regimen came from PPH, for old/fragile/sick people. This may address you, could decrease discomfort. Stat is effective, great, easy option for many people. Taking it with benzo &
Antiemetics - Stat/Regimen Guidelines​
What are the dosages/schedule?	Read guide. Follow everything there. – This section intended only for details not in guide – .
Domperidone - Stat	Same as meto. Notes
Prochlorperazine – Stat	Smaller dosage – 10 to 20 mg Notes
Meto – Regimen	See guide. Schedule however more flexiblethan commonly published – Just take 3 a day over 24-48h morning lunch evening, 7-9h apart
Domperidone – Regimen	Same. Best to stick with it. Member was fine after trying 48h regimen x 20mg (instead of 10mg) Research concludes: Acummulation – "2 to 3-fold accumulation observed with repeated 4 times daily every 5 hr for 4 days." But only 3+ a day – "after two weeks of single 30mg per day peak plasma level almost same"
Prochlorperazine – Regimen	Same as Meto (10mg x 3 times a day) – but final dose smaller , like Stat Notes
Fasting – important?​	Yes, but flexible. Don't overdo it, follow your habits. 5h – Empty stomach, partially small intestines – Good enough. 8h – Empty most small intestines – Good. 12h – Long fasting not required (may cause discomfort). According to your habits/feeling; if you eat just twice a day, 12h fine.

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Acid-stuff​
What they do:	Stomach acidity May help SN absorption Stan detailed that process
Do I need those?	No. But many use these. Considered helpful, widely-available, cause little harm.
Are they available?	OTC / Internet Milk of Magnesia – widely available, just as effective. For other brands – search big sites
(1) Antacids
What they do:	Neutralizes acid on the spot
Known antacids:	Any antacid with magnesium hydroxide. Check any available OTC for ingredients with that. Milk of Magnesia.
Can I use other antacids?	We don't know. PPH pervioiusly recommended sodium bicarbonate, this was changed to acid-regulator.
(2) Acid-regulators
What they do:	Unlike antacids they reduce acid creation beforehand
Which should I use?	H2-receptor antagonists only
Which I should not use?	Proton pump inhibitors (PPI) do not work. Don't use them . Check medication ingredients and google to check if it's PPI .
What if I'm already taking acid-regulators?	If PPI used regularly, as part of health treatment – Continue your PPI as normal (don't use antacids or acid-regulators) . If PPI used occasionally – you can try to replace it with acid-regulators listed below (test it).
Known acid-regulators:	Cimetidine/Tagamet, Rantidine/Zantac, Famotidine
Can I use other acid-regulators?	No. May interfere with absorption.
Other Questions
Which should I use?	Either is fine, whatever you want.
Can I use antacids and acid-regulators together?	We don't know. Probably not good to mix.
Wiki says not to use acid-regulators	Stan recommended plain antacid, and gave acid-regulators which should work as well. The wiki reference was deemed incomprehensible (here, here, here)

Benzo / Sedatives​
What they do:	Reduce anxiety Reduce bad physical sensations Induce sleep
Do I need it?	No, many didn't use these at all But considered useful for anxiety and peaceful journey
Are they available?	Kinda. Prescription only – but very common In many places GPs prescribe benzo for many reasons.
Warnings:	Yes, though not harmful: Benzos effects vary greatly: Potency, tolerance, onset (how quick), duration (how long) change. Some benzo affects within 10m, others take 1h, and this changes individually Taken too soon – may fall asleep before SN. Test small dosage beforehand.
Which benzo to use? Is benzo X good?	Can't answer that. There are dozens. Anything that affects you more than 4h. Personally check this. Benzo "half-life" does not indicate long/short effects.
Other Sedatives​
Can I use opioids?	YES. But: Check contraindications Note anything of the opioid family significantly reduces: metabolism gastric emptying intestinal absorption May take twice the time.

Beta Blockers​
What they do:	Reduce fast strong heartbeat after SN May reduce possible headache These meds reduce blood pressure.
Do I need it?	No. Most people dont use it ; considered somewhat of luxury Some already use these, or find it easy to get due to prior conditions. Benzo/painkillers should help with sensations.
Are they available?	Prescription only. You should consult physician.
Which should I use?	Propanolol
Can I use others?	We don't know

Painkillers​
What they do:	Many experience moderate headache or general pain (rated 4/10): Helps headaches or pain
Do I need it?	No. But almost everyone use these. Considered helpful, widely-available, cause little harm.
Are they available?	OTC​
Which should I use?	Ibuprofen, or Paracetamol/acetaminophen
Can I use others?	Yes General NSAIDs that works for you Specific pain medication that works for you

 

[Dominicka]

Hey sorry to bump an old thread but this my AE too. I was planning 30mg stat dose. This guide says 40 max but I saw a FAQ guide that to take a smaller dose of Prochlorperazine 10-20mg. Anyone have input?
Not an old thread lol sorry. Cheers whoops

Wondering about this too, can anyone help us? I don't wanna

 

[4g1vvvven]

Shameless bump, Stan used buccastem/Prochlorperazine I believe, is there no guidance on the dosage for a stat dose?