Discussion What antiemetics will work?

[Mizuri]

Antiemetics for the stomach flu​

Spoiler

Some people with gastroenteritis, or the stomach flu, need antiemetics to relieve their symptoms.

While vomiting can help get rid of any stomach irritants, excessive vomiting can damage the digestive tract. Nausea may also prevent a person from eating and drinking enough to take in necessary nutrients and stay hydrated.

The over-the-counter medications below can ease the nausea as the body fights off the infection:

• sodium citrate, dextrose, and fructose (Nauzene)
• orthophosphoric acid, fructose, and glucose (Emetrol)
• bismuth subsalicylate (Pepto Bismol)

Antiemetics after surgery​

Spoiler

People who undergo anesthesia for surgery frequently experience nausea and vomiting afterward.

Several drugs can help, including serotonin receptor blockers, dopamine receptor blockers, and some corticosteroids.

Antiemetics that a doctor may prescribe after surgery include:

• dexamethasone (Decadron)
• droperidol (Inapsine)
• granisetron (Kytril)
• metoclopramide (Reglan)
• ondansetron (Zofran)

Antiemetics for cancer and chemotherapy​

Spoiler

Chemotherapy often causes nausea and vomiting. A doctor may prescribe an antiemetic before and after chemo to help prevent these side effects and improve the quality of life.

Different types of drugs can help, including serotonin and dopamine receptor blockers, NK1 receptor blockers, and corticosteroids.

Some antiemetics that people take to combat nausea from chemotherapy include:

• aprepitant (Emend)
• dexamethasone (DexPak)
• dolasetron (Anzemet)
• granisetron (Kytril)
• ondansetron (Zofran)
• palonosetron (Aloxi)
• prochlorperazine (Compazine)
• rolapitant (Varubi)

Source on medications
Stan's guide on SN (Section: "What do I need and why?")

Names in bold are the substances mentioned in Stan's guide on SN.

Why is it so that no medications from "Antiemetics for the stomach flu" section are mentioned in Stan's guide? Do they not work correctly with the SN? Is it because the medication must be specifically blocking the dopamine receptor? Do antiemetics from "Antiemetics for the stomach flu" section of the article also work?

 

[DetachedDreamer97]

Metoclopramide seems like the most optimal antiemetic, and is best supplemented with odansetron. Basically any central and peripheral D2 antagonists are ideal and 5ht3 blockers are also good when combined.

Another thing is that scopolamine might also work if you can't have access to either as it inhibits the vomiting centre (final pathway) directly as well as also inhibiting 5ht3 receptors competitively. That said, one issue with scopolamine is that muscarinic acetylcholine antagonists inhibit gastric motility, which will likely delay absorption of SN.

As for stomach flu otc antiemetics, not likely.

 

[Sacred Rest]

Metoclopramide seems like the most optimal antiemetic, and is best supplemented with odansetron. Basically any central and peripheral D2 antagonists are ideal and 5ht3 blockers are also good when combined.

Another thing is that scopolamine might also work if you can't have access to either as it inhibits the vomiting centre (final pathway) directly as well as also inhibiting 5ht3 receptors competitively. That said, one issue with scopolamine is that muscarinic acetylcholine antagonists inhibit gastric motility, which will likely delay absorption of SN.

As for stomach flu otc antiemetics, not likely.

Hey. Thanks for the explanation. I have a question about AE's and N. I have my own Meto & N acquired. I was able to take 10 mg without any noticeable problems besides the runs after eating, but I worry about Extrapyramidal Symptoms when I take the required 30 mg dose 1h to 1h 30m before. I'm considering some alternative AE regimens, that I sent you a PM about. Hopefully you have the time to get back to me. And thanks again.

 

[PeacefulTonic]

Hey. Thanks for the explanation. I have a question about AE's and N. I have my own Meto & N acquired. I was able to take 10 mg without any noticeable problems besides the runs after eating, but I worry about Extrapyramidal Symptoms when I take the required 30 mg dose 1h to 1h 30m before. I'm considering some alternative AE regimens, that I sent you a PM about. Hopefully you have the time to get back to me. And thanks again.

Why not just try a 30mg dose trial run if you're really worried about it?

 

[Sacred Rest]

Why not just try a 30mg dose trial run if you're really worried about it?

I have Chronic Kidney Disease (CKD) and associated Illnesses that I haven't received treatment for yet from a pharmaceutical drug poisoning as a result of a doctoral malpractice, so I'm Terminal / Done For either way. The dosages for all medications should be lower for those with my illness, but I really don't want to deal with Extrapyramidal Symptoms in any case, so even doing the trial for 30 mg is something I'm hesitant and worry about. EPS would be pretty uncomfortable if it lasts a long time, and would foil my attempt. Though, I did get through 10 mg without any serious problems.

I was thinking of doing something like 20 mg Meto & 8 mg Zofran before the N, Or the 48 hour Meto regimen, Or 20 mg Domperidone. I don't know yet. I still need more sources to consider for fast and reliable shipping AE's. I'm thinking. Thanks for the reply :)

 

[PeacefulTonic]

I believe the updated PPeH suggests Zofran along with the Meto now. Not sure about the dosing

 

[DetachedDreamer97]

Hey. Thanks for the explanation. I have a question about AE's and N. I have my own Meto & N acquired. I was able to take 10 mg without any noticeable problems besides the runs after eating, but I worry about Extrapyramidal Symptoms when I take the required 30 mg dose 1h to 1h 30m before. I'm considering some alternative AE regimens, that I sent you a PM about. Hopefully you have the time to get back to me. And thanks again.

Saw it! And no problem!

 

[Sacred Rest]

I believe the updated PPeH suggests Zofran along with the Meto now. Not sure about the dosing

Yeah, I've heard that mentioned in other threads as well, though I only have the August version of the PPH. I'm not an exit member, and kind of on borrowed time now anyway. Though, I have read a couple of threads here that have suggested 20 mg Meto & 8 mg Zofran, or 30 mg Meto & 8 mg Zofran. It would be nice to hear a final answer on the Meto & Zofran combination dosage. If all gets worse for me quickly, I may just do a Hail Mary with a 20-30 mg Meto dosage 1h 30m before.

As a side question, I've also acquired dilantin, which can potentiate the N with cardiac collapse thereby guaranteeing death 100%, but I've heard the death is not so peaceful if still conscious at the time of effect. I have it, but I don't know if it's worth it in my case. Thoughts?

Oh, and one more thing. I also have access to legally sourced THC & CBD from cannabis, so this would help with Antinausea and Antiemetic effects.

 

[PeacefulTonic]

I just wanted to say that I'm sorry that you're terminally ill and I hope that you got to at least enjoy some of your life.

I think the other stuff might be overkill. But most slip into a coma within 5-15 minutes. How long does Dilantin take to kick in? Some people don't even use AE and have successfully ctb'd with N, I wouldn't even worry too much about that part

 

[Cheers]

Does anyone know about meclizine? It's also supposed to be a dopamine antagonist, would it work as well or still be better than nothing at least?

 

[DetachedDreamer97]

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Does anyone know about meclizine? It's also supposed to be a dopamine antagonist, would it work as well or still be better than nothing at least?

It may work, but considering it's mainly antihistamine and anticholinergic, and is said mainly to block vestibular nausea, you might want to research further and see how well it blocks dopamine. I have heard of meclizine being potentially effective on here though.

 

[PeacefulTonic]

Does anyone know about meclizine? It's also supposed to be a dopamine antagonist, would it work as well or still be better than nothing at least?

It's definitely better than using nothing that's for sure