Terminally ill
Member
- May 27, 2019
- 95
Here is the information Suicide wiki has on Antacids:
Using antacids (also known as acid regulators) is discouraged. The antacid section of Suicide Wiki is provided here only because you will encounter with antacids in the PPH. The PPH recommends decreasing your stomach's fluid volume to make the sodium nitrite absorbed more quickly. This can be accomplished with drugs like ranitidine, famotidine, or cimetidine that reduce the stomach acid quickly. The recommended dose in the PPH is 800mg cimetidine (sold under the brand name Tagamet), which is equivalent to 3 – 4 * 75 mg ranitidine (sold under the brand name Zantac).
Stat dose (30 – 45 minutes before SN intake)
• 800 mg cimetidine (Tagamet)
or
• 3 * 75 mg ranitidine (Zantac)
The PPH previously recommended sodium bicarbonate as absorption accelerator. The PPH argued that sodium bicarbonate would raise the stomach's fluid pH. The raise in stomach's fluid pH hindered loss of consciousness in some patients—although it was expected, given that the blood pressure—lowering effect of orally ingested nitrite was abolished when test persons were pretreated with a proton pump inhibitor (PPI) to raise gastric pH (Montenegro et al., 2016). Similar to sodium bicarbonate, the blood pressure-lowering effect of orally ingested nitrite is abolished by a proton pump inhibitor (Piknova & Schechter, 2017). Since the release of the October 2018 revision, the PPH suggests Tagamet (instead of sodium bicarbonate) and has misguidedly argued "this effect is not related to gastric pH, but rather to the production rate of acid." While the PPH still incorrectly recommends using H2 receptor antagonists, such as cimetidine and ranitidine, simply not using them will result in a more peaceful death, owing to formation of nitric oxide, a vasodilator, in acidic (Malko, Kucernak & Lopes, 2016) gastric environment—in pH less than 6.51 (Pereira, Ferreira, Rocha, Barbosa & Laranjinha, 2013)—as shown in pathway A[1|2].
Without antacid: 3NaNO2 + 2HCl → 2NaCl + NaNO3 + 2NO + H2O
Questions:
1. Why does Suicide Wiki discourage Antacids and says " While the PPH still incorrectly recommends using H2 receptor antagonists, such as cimetidine and ranitidine, simply not using them will result in a more peaceful death, owing to formation of nitric oxide"
2. In Stans guide and people here do use Antacids in most cases from what I have seen. I am only able to find Famotidine in my country. The info I found on Famotidine is the following: Famotidine prooved to be 9X more potent than Ranitidine and 32 X more potent than Cimetidine. The dosage are is 40 mgs/tablet. Would I take one or two of these?
3. Since all the information on antacids is contradictory in Wiki suicide vs PPH what would be better? Take Famotidine above or take an Acid Reducer-I can only find RENNIE tabs and that does NOT have Magnsium Hidroxide as recommended by Stan but the following ingredients: calcium carbonate, magnesium carbonate, alginic acid amongst other ingredients
So what do you suggest to do, what would you do? Thanks
Using antacids (also known as acid regulators) is discouraged. The antacid section of Suicide Wiki is provided here only because you will encounter with antacids in the PPH. The PPH recommends decreasing your stomach's fluid volume to make the sodium nitrite absorbed more quickly. This can be accomplished with drugs like ranitidine, famotidine, or cimetidine that reduce the stomach acid quickly. The recommended dose in the PPH is 800mg cimetidine (sold under the brand name Tagamet), which is equivalent to 3 – 4 * 75 mg ranitidine (sold under the brand name Zantac).
Stat dose (30 – 45 minutes before SN intake)
• 800 mg cimetidine (Tagamet)
or
• 3 * 75 mg ranitidine (Zantac)
The PPH previously recommended sodium bicarbonate as absorption accelerator. The PPH argued that sodium bicarbonate would raise the stomach's fluid pH. The raise in stomach's fluid pH hindered loss of consciousness in some patients—although it was expected, given that the blood pressure—lowering effect of orally ingested nitrite was abolished when test persons were pretreated with a proton pump inhibitor (PPI) to raise gastric pH (Montenegro et al., 2016). Similar to sodium bicarbonate, the blood pressure-lowering effect of orally ingested nitrite is abolished by a proton pump inhibitor (Piknova & Schechter, 2017). Since the release of the October 2018 revision, the PPH suggests Tagamet (instead of sodium bicarbonate) and has misguidedly argued "this effect is not related to gastric pH, but rather to the production rate of acid." While the PPH still incorrectly recommends using H2 receptor antagonists, such as cimetidine and ranitidine, simply not using them will result in a more peaceful death, owing to formation of nitric oxide, a vasodilator, in acidic (Malko, Kucernak & Lopes, 2016) gastric environment—in pH less than 6.51 (Pereira, Ferreira, Rocha, Barbosa & Laranjinha, 2013)—as shown in pathway A[1|2].
Without antacid: 3NaNO2 + 2HCl → 2NaCl + NaNO3 + 2NO + H2O
Questions:
1. Why does Suicide Wiki discourage Antacids and says " While the PPH still incorrectly recommends using H2 receptor antagonists, such as cimetidine and ranitidine, simply not using them will result in a more peaceful death, owing to formation of nitric oxide"
2. In Stans guide and people here do use Antacids in most cases from what I have seen. I am only able to find Famotidine in my country. The info I found on Famotidine is the following: Famotidine prooved to be 9X more potent than Ranitidine and 32 X more potent than Cimetidine. The dosage are is 40 mgs/tablet. Would I take one or two of these?
3. Since all the information on antacids is contradictory in Wiki suicide vs PPH what would be better? Take Famotidine above or take an Acid Reducer-I can only find RENNIE tabs and that does NOT have Magnsium Hidroxide as recommended by Stan but the following ingredients: calcium carbonate, magnesium carbonate, alginic acid amongst other ingredients
So what do you suggest to do, what would you do? Thanks
