I have seen a range of dosages suggested in these threads but the ones suggesting thousands of MG of hydrocodone seem out of line. From what I've been able to see on various search engines, a fatal dose of hydrocodone can vary significantly depending on several factors, including a person's tolerance, age, weight, general health, and whether the individual is using other substances (such as alcohol or benzodiazepines). Generally, for someone without a tolerance to opioids, doses over 50 mg could be dangerous, and anything higher could be life-threatening. Hydrocodone is considered a potent opioid, and taking it in large amounts can lead to respiratory depression, coma, or death. It's essential to only use hydrocodone as prescribed by a healthcare provider and never exceed the recommended dosage. The following one table I found.
| Total Oral Dose | Est. Blood Level | Risk |
|---|
| 10 mg (1 tab) | ~0.25–0.3 mg | Therapeutic |
| 20 mg | ~0.6 mg | Still typically safe |
| 40–60 mg | ~1.2–1.8 mg | Possibly dangerous in sensitive individuals |
| 80–120+ mg | 2.5–4+ mg | Lethal zone for many, especially with other drugs |
So:
It would likely take at least 8–12 tablets (80–120 mg) taken all at once
to reach lethal levels—and often more.
Another factor to consider is that alcohol acts as an "accelerant" for virtually any opiods.
Apologies for being so wordy.
