I was browsing Sasu and came across this article
sanctioned-suicide.net
And there is a lot of misinformation
Converting the LD50 from animals to humans has no scientific value
Different metabolism, enzymes, etc....
Furthermore, there is no mention of how the LD50 was administered to the animal... we don't know if it was oral or IV...
Some models attempt to convert the LD50 to humans
And you have to use body surface area, not just weight
HED (mg/kg) = Animal dose (mg/kg) Ă— (Animal Km / Human Km)
With
Km = Poids corporel (kg) / Surface corporelle (m²)
Ex
According to the article,
the LDâ‚…â‚€ of Xanax is between 300 and 2,100 mg/kg
Indeed, if I simply calculate by multiplying the LDâ‚…â‚€ by the human body weight, I get the same values as the article
But by using the actual formula for
a man who is 170 cm tall and weighs 68 kg, we get:
Body surface area = 1.79 m²
Km = 38
For rat Km = 6
So using the formula:
We get a human LDâ‚…â‚€ of approximately 37.37 mg/kg for an animal LDâ‚…â‚€ of 300 mg/kg, which is 47 1-mg tablets or 95 0.5-mg tablets per 1 kg
For a weight of 68 kg, more than 2,500 tablets would be needed to reach the human LD50
It's still a huge number, but well below the article's overestimates
The vast majority of overdoses fail due to several factors:
- often an impulsive and ill-prepared attempt
- limited access to medication, which can be dangerous: most of the time, people take whatever they have on hand—benzodiazepines, antidepressants, aspirin, etc. These are medications with a very wide safety margin; taking a whole pack of benzos or antidepressants won't kill you...
So if you can't get your hands on potentially legal drugs—barbiturates, opioids, etc.—an overdose isn't really an option for you.
I've read in several articles that 70% of successful overdoses involve a combination of opioids and benzos.
And in over 90% of cases, there was multiple drug intoxication: mainly cardiotoxic and central nervous system depressants.
In conclusion,
an overdose is possible under certain conditions—if you have the right combination of drugs.
Thank you all for reading.
I wish you all the best.
Why ODs Fail Miserably (A Guide)
There's still a lot of questions and inquiries about ODs, and people asking about what things may facilitate a successful attempt. Let's be clear, ODs are rarely fatal. Why? For a couple of reasons: (1) modern medications are designed to be very safe, as manufacturers aim to avoid deaths that...
sanctioned-suicide.net
And there is a lot of misinformation
Converting the LD50 from animals to humans has no scientific value
Different metabolism, enzymes, etc....
Furthermore, there is no mention of how the LD50 was administered to the animal... we don't know if it was oral or IV...
Some models attempt to convert the LD50 to humans
And you have to use body surface area, not just weight
HED (mg/kg) = Animal dose (mg/kg) Ă— (Animal Km / Human Km)
With
Km = Poids corporel (kg) / Surface corporelle (m²)
Ex
According to the article,
the LDâ‚…â‚€ of Xanax is between 300 and 2,100 mg/kg
Indeed, if I simply calculate by multiplying the LDâ‚…â‚€ by the human body weight, I get the same values as the article
But by using the actual formula for
a man who is 170 cm tall and weighs 68 kg, we get:
Body surface area = 1.79 m²
Km = 38
For rat Km = 6
So using the formula:
We get a human LDâ‚…â‚€ of approximately 37.37 mg/kg for an animal LDâ‚…â‚€ of 300 mg/kg, which is 47 1-mg tablets or 95 0.5-mg tablets per 1 kg
For a weight of 68 kg, more than 2,500 tablets would be needed to reach the human LD50
It's still a huge number, but well below the article's overestimates
The vast majority of overdoses fail due to several factors:
- often an impulsive and ill-prepared attempt
- limited access to medication, which can be dangerous: most of the time, people take whatever they have on hand—benzodiazepines, antidepressants, aspirin, etc. These are medications with a very wide safety margin; taking a whole pack of benzos or antidepressants won't kill you...
So if you can't get your hands on potentially legal drugs—barbiturates, opioids, etc.—an overdose isn't really an option for you.
I've read in several articles that 70% of successful overdoses involve a combination of opioids and benzos.
And in over 90% of cases, there was multiple drug intoxication: mainly cardiotoxic and central nervous system depressants.
In conclusion,
an overdose is possible under certain conditions—if you have the right combination of drugs.
Thank you all for reading.
I wish you all the best.
