tapentadol and morphine cross tolerance

[MariV]

well as some of you may remember, i was planning to ctb at home. my mother says she agrees but at the end she always tries to stop me.

my idea is taking my box of morphine pills, going to some park and take them there. the pills are 1800mg in total but i wonder if taking tapentadol 50mg has given me already some tolerance. and also if i would puke.

but it would be a very practical way. just take the box, a bottle of water and leave home at night

 

[grungeCat]

Well, there is cross tolerance between morphine and tapentadol. But gaining tolerance is a slow and tedious process. To increase your tolerance in signicifant way you would have to abuse tapentadol for a few days at least. One small dosage (50 mg in terms of drug addiction is actually zero dosage) doesn't change your tolerance to opio at all.

Also I don't know if you will throw up. Injecting morphine always gives me very strong nausea although it never happenned when taken orally. I have never taken such a dosage though. However I used to take 100 pills of codeine at once and I had no problem with vomitting so you should be fine I guess.

 

[MariV]

yes. ive been taking 50mg 2 times a day for a couple of months of tapentadol. now it would be 60 pills of 30mg morphine which i would crush and dissolve in water. my concern is puking.
i aldo have SN at home but i have the impression a morphine OD is more peaceful

 

[grungeCat]

yes. ive been taking 50mg 2 times a day for a couple of months of tapentadol. now it would be 60 pills of 30mg morphine which i would crush and dissolve in water. my concern is puking.
i aldo have SN at home but i have the impression a morphine OD is more peaceful

Oh, in that case there is a real problem. There's not a objective method to test and define your tolerance.

 

[MariV]

well ive taken one of the morphine pills 30mg i got and felt quite dizzy and light-headed. and absolite 0 pain. that should mean they affect me considerably, no?

 

[schopenh]

Agree with the cat. You're taking in about 40MME on a daily basis. After a few months, I'm assuming you barely get anything from them compared to when you started? Tolerance doesn't appear to be linear to me, but rather, logarithmic. If 50 mg does nothing much for you any more, then doubling or even tripling it possibly still won't do near as much as when you first took 50. I'd recommend tapering off them (slowly) before trying to OD on morphine. I was also taking tapentadol, at its highest it was 100 mg twice a day. But it was mostly 100 mg once a day for months. Tapering off has been a slow and arduous process, but I am down to basically 1/16th of a 100 mg tablet now. I'll just stop altogether in a couple of weeks.

EDIT: by the way, by the time I hit 10 mg twice a day, both were doing nothing for me.

 

[MariV]

Agree with the cat. You're taking in about 40MME on a daily basis. After a few months, I'm assuming you barely get anything from them compared to when you started? Tolerance doesn't appear to be linear to me, but rather, logarithmic. If 50 mg does nothing much for you any more, then doubling or even tripling it possibly still won't do near as much as when you first took 50. I'd recommend tapering off them (slowly) before trying to OD on morphine. I was also taking tapentadol, at its highest it was 100 mg twice a day. But it was mostly 100 mg once a day for months. Tapering off has been a slow and arduous process, but I am down to basically 1/16th of a 100 mg tablet now. I'll just stop altogether in a couple of weeks.

EDIT: by the way, by the time I hit 10 mg twice a day, both were doing nothing for me.

well the 50mg i take twice a day still remove most of the pain. i could try to stop taking them but only if was sure that a 1800mg oral morphine dose would be effective. the info is so confusing. some say you can die on just 200mg of morphine. others, that you need several grams.its so hard to find the truth.
i could also resort to my SN but opioids sound much more pleasant

Agree with the cat. You're taking in about 40MME on a daily basis. After a few months, I'm assuming you barely get anything from them compared to when you started? Tolerance doesn't appear to be linear to me, but rather, logarithmic. If 50 mg does nothing much for you any more, then doubling or even tripling it possibly still won't do near as much as when you first took 50. I'd recommend tapering off them (slowly) before trying to OD on morphine. I was also taking tapentadol, at its highest it was 100 mg twice a day. But it was mostly 100 mg once a day for months. Tapering off has been a slow and arduous process, but I am down to basically 1/16th of a 100 mg tablet now. I'll just stop altogether in a couple of weeks.

EDIT: by the way, by the time I hit 10 mg twice a day, both were doing nothing for me.

you mean 100mg right?

 

[schopenh]

well the 50mg i take twice a day still remove most of the pain. i could try to stop taking them but only if was sure that a 1800mg oral morphine dose would be effective. the info is so confusing. some say you can die on just 200mg of morphine. others, that you need several grams.its so hard to find the truth.
i could also resort to my SN but opioids sound much more pleasant

you mean 100mg right?

Sorry, yep. 100 mg twice a day were doing nothing for me

 

[Aap]

the morphine dosage is good. Make sure the pills are not swallowed whole.

 

[Infinite Conscious]

OP does not have time to taper off... he needs a quick solution, as he's in constant pain.
The guy is 48kg and 188cm... stomach cancer, can't eat, even his mother supports his decision.

MariV, just go ahead with it... you always have SN left for a plan B, if you fail with morphine.
It hurts just to think of your situation.

That dosage should be fine, especially taking into account your physical state.
Best of luck and safe journey.

 

[MariV]

MariV, just go ahead with it... you always have SN left for a plan B, if you fail with morphine.
It hurts just to think of your situation.

yes the thing is that an opioid OD failure could leave me in a vegetative state where o couldnt do anything. scary. i think SN is safer no?

 

[Infinite Conscious]

yes the thing is that an opioid OD failure could leave me in a vegetative state where o couldnt do anything. scary. i think SN is safer no?

I have never heard of any such case in which an opioid OD left the person in a vegetative state.
I used heroin for 15 years in total, I have encountered A LOT of users of the worst kind, and never heard of such a case.
Opiates do not prevent oxygen from getting to the brain, which is a prerequisite for brain damage causing - "vegetables".
I am 99% sure this is a myth... but of course, I am not omniscient, I could be mistaken.

Vegetative state is more probable with failed hanging attempts, failed jumping attempts, failed shooting attempts... but not morphine or heroin.

Of course, SN is always a viable option, you had an opportunity last night to see how quick and simple it can be (LetzteAusfahrt).
10 minutes and... game over.

 

[MariV]

I have never heard of any such case in which an opioid OD left the person in a vegetative state.
I used heroin for 15 years in total, I have encountered A LOT of users of the worst kind, and never heard of such a case.
Opiates do not prevent oxygen from getting to the brain, which is a prerequisite for brain damage causing - "vegetables".
I am 99% sure this is a myth... but of course, I am not omniscient, I could be mistaken.

Vegetative state is more probable with failed hanging attempts, failed jumping attempts, failed shooting attempts... but not morphine or heroin.

Of course, SN is always a viable option, you had an opportunity last night to see how quick and simple it can be (LetzteAusfahrt).
10 minutes and... game over.

indeed...but the thing is i have stomach ulcers and have pain after eating althogj not severe. so maybe SN causes a lot of pain even with analgesics.

so i thought about the morphine pills they gave me.60pillsx30mg. but i think i will puke them