todienomore
Arcanist
- Apr 7, 2023
- 415
Death due to ingestion of nicotine-containing solution: Case report and
review of the literature
"Nicotine acts on the parasympathetic and sympathetic nervous
system, where it binds to acetylcholine receptors. In general, the
central nervous system is stimulated by small doses of nicotine but
depresses by large doses [25,26].
The estimated lethal dose of nicotine in adults ranges from 0.5
to 1.0 mg/kg of body weight, corresponding to a total dose of 30–
60 mg [27]. Toxic symptoms might be seen at doses as low as 2–
5 mg. However, individuals vary widely in their tolerance to the
toxic effects of nicotine [6].
Non-fatal cases of intentional or unintentional nicotine
intoxication have been reported in the literature [6,28–33]. In
such cases, nicotine stimulates autonomic ganglia and induces the
classical effects of cholinergic excess, such as muscle fasciculations
and muscarinic symptoms (nausea, vomiting, increased salivation,
dizziness, headache, and vision or hearing changes). Massive
nicotine ingestion frequently causes dangerous medical complica-
tions such as seizures, central nervous system changes, cardio-
vascular effects and respiratory failure [34–36]. Victims who are
not hospitalized immediately may face rapid progression to
hypotension and death. The most common mechanisms of death
from nicotine intoxication are respiratory failure due to peripheral
neuromuscular blockade and cardiovascular arrest [5,7,16].
Though nicotine is one of the most toxic drugs of abuse, it rarely
leads to fatalities. Fatal poisoning from concentrated-nicotine
solution and pesticides have occurred in the past [8–17,37,38], and
nicotine has been reported to cause death in two cases [18,39].
However, only a few cases of fatal nicotine poisoning have been
reported during the last 20 years [8,16,17]."
Death related to nicotine replacement therapy: A case report
"High doses of nicotine inhibit the central nervous system,
inducing hypotension and bradycardia followed by coma and
respiratory muscle paralysis, leading to death by asphyxia. The first
evidences of police investigation and autopsy findings suggested
nicotine poisoning. Indeed, the autopsy revealed signs of asphyxia
syndrome (congestion of the face, conjunctival injection, reddish
mucus in the nose and mouth, cyanosis of the lips, multi-organ
congestion and considerable pulmonary oedema)."
Found that here https://scholar.google.com/scholar?hl=en&as_sdt=0,4&q=fatal+nicotine+poisoning+&btnG=
Almost any article that is behind a paywall can be read on Sci Hub.
There were more relevant articles but I am too lazy, might add them later. I hope some of you will keep looking.
This really doesn't sound that bad, you just have to hit a high dose and you're done within minutes. 100-200mg+ orally and/or with patches. I'll keep searching for first hand experiences of an overdose or at least a few second hand ones of the early symptoms. Sounds like vomiting and twitches are guaranteed right before you drop out. But within a couple minutes, you are on to severe respiratory depression, low pulse, and heart issues. To me it sounds halfway unpleasant but not really painful, quickly leading to unconsciousness fatal complications.
Please dont shit up the thread, just post more studies, case reports or scientific anecdotes. Its very different in comparison to just smoking too many cigarettes, a ganglion block means your body stops telling your lungs to breathe among other important things.
review of the literature
"Nicotine acts on the parasympathetic and sympathetic nervous
system, where it binds to acetylcholine receptors. In general, the
central nervous system is stimulated by small doses of nicotine but
depresses by large doses [25,26].
The estimated lethal dose of nicotine in adults ranges from 0.5
to 1.0 mg/kg of body weight, corresponding to a total dose of 30–
60 mg [27]. Toxic symptoms might be seen at doses as low as 2–
5 mg. However, individuals vary widely in their tolerance to the
toxic effects of nicotine [6].
Non-fatal cases of intentional or unintentional nicotine
intoxication have been reported in the literature [6,28–33]. In
such cases, nicotine stimulates autonomic ganglia and induces the
classical effects of cholinergic excess, such as muscle fasciculations
and muscarinic symptoms (nausea, vomiting, increased salivation,
dizziness, headache, and vision or hearing changes). Massive
nicotine ingestion frequently causes dangerous medical complica-
tions such as seizures, central nervous system changes, cardio-
vascular effects and respiratory failure [34–36]. Victims who are
not hospitalized immediately may face rapid progression to
hypotension and death. The most common mechanisms of death
from nicotine intoxication are respiratory failure due to peripheral
neuromuscular blockade and cardiovascular arrest [5,7,16].
Though nicotine is one of the most toxic drugs of abuse, it rarely
leads to fatalities. Fatal poisoning from concentrated-nicotine
solution and pesticides have occurred in the past [8–17,37,38], and
nicotine has been reported to cause death in two cases [18,39].
However, only a few cases of fatal nicotine poisoning have been
reported during the last 20 years [8,16,17]."
Death related to nicotine replacement therapy: A case report
"High doses of nicotine inhibit the central nervous system,
inducing hypotension and bradycardia followed by coma and
respiratory muscle paralysis, leading to death by asphyxia. The first
evidences of police investigation and autopsy findings suggested
nicotine poisoning. Indeed, the autopsy revealed signs of asphyxia
syndrome (congestion of the face, conjunctival injection, reddish
mucus in the nose and mouth, cyanosis of the lips, multi-organ
congestion and considerable pulmonary oedema)."
Found that here https://scholar.google.com/scholar?hl=en&as_sdt=0,4&q=fatal+nicotine+poisoning+&btnG=
Almost any article that is behind a paywall can be read on Sci Hub.
There were more relevant articles but I am too lazy, might add them later. I hope some of you will keep looking.
This really doesn't sound that bad, you just have to hit a high dose and you're done within minutes. 100-200mg+ orally and/or with patches. I'll keep searching for first hand experiences of an overdose or at least a few second hand ones of the early symptoms. Sounds like vomiting and twitches are guaranteed right before you drop out. But within a couple minutes, you are on to severe respiratory depression, low pulse, and heart issues. To me it sounds halfway unpleasant but not really painful, quickly leading to unconsciousness fatal complications.
Please dont shit up the thread, just post more studies, case reports or scientific anecdotes. Its very different in comparison to just smoking too many cigarettes, a ganglion block means your body stops telling your lungs to breathe among other important things.
