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Bitcoin (BTC):Ethereum (ETH):Monero (XMR):Hi, first of all. I'm really sorry for really late reply. So here it goes:
Don't use GHB with alcohol, prior research shows that 6 out of 7 people who use GHB with alcohol throw up and that definitely throws off your attempt.
GHB and Ethanol Effects and Interactions in Humans - PMC
Gamma-hydroxybutyrate (GHB) is a common drug of abuse that can produce serious toxicity, particularly when used with other sedatives. We examined the individual and combined effects of GHB and ethanol in human volunteers. Sixteen healthy adults (7 ...
pmc.ncbi.nlm.nih.gov
I'd definitely recommend using GHB, Alprazolam, and Zolpidem as a sedatives on other methods, such as hanging or SN.
It's been a while since I've entered darkweb, but my bet is phenobarbital is available on there. Just beware of the scams, though...
Sure, go ahead. I hope I can answer it.
Are you sure you're not confusing it with Pentobarbital/Nembutal? Phenobarbital is a slower acting barbiturate so I believe it takes a lot longer.
First of all, I'm sorry for the long wait.
Second of all, surprisingly there are no reported fatal case of phenobarbital poisoning. Every single fatal poisoning recorded has been treated in some way and the patient has recovered. So there are no clear answer on how long phenobarbital overdose can kill you. However, due to the same mechanism barbiturates have in overdose, approximately death occurs at >6-12 hours after ingestion.
Enhanced elimination in acute barbiturate poisoning - a systematic review - PubMed
There is limited evidence to support the use of enhanced elimination in the treatment of poisoning with most barbiturates. There is no role for urine alkalinisation, while multiple-dose activated charcoal may be useful for most phenobarbital and possibly primidone poisonings. Extracorporeal...
pubmed.ncbi.nlm.nih.gov
ShadowOfASelf
Member
- Feb 10, 2026
- 48
Sorry to necro this thread, but do you or anybody else know if it's possible to OD on drugs via suppositories? I have a lot of baclofen in suppository form (as well as Valium) and wonder if that's a viable CTB method or viable combined with other oral medications/alcohol/etc (I have Benadryl, Clonazepam, amitriptyline and nortriptyline though I don't think I have high enough doses of those to do anything, zopiclone, quviviq, pregabalin, and prazosin)First of all, I want to said I'm really sorry for the long wait. College stuff and irl conditions make me busy rn.
View attachment 177789
Converting table from this publication I mentioned: https://pmc.ncbi.nlm.nih.gov/articles/PMC4804402/. I think I'll needing this more later on so I'll just post it here lol.
Your question has 3 topics, here's how it goes:
1. Baclofen overdose
Here's a data sheet about baclofen:
LD50 for oral route in rat is 50 – 300 mg/kg. From the publication above we can make its HED into this:
HED = 50 x 0.162 = 8.1 mg/kg
HED = 300 x 0.162 = 48.6 mg/kg
So we can deduct that LD50 for oral route for human is around 8,1-48,6 mg/kg.
There is actually a lot of good publications about baclofen overdose. I pick one that's a really good publication about baclofen overdose, here goes:
Baclofen therapeutics, toxicity, and withdrawal: A narrative review - PMC
Baclofen is an effective therapeutic for the treatment of spasticity related to multiple sclerosis, spinal cord injuries, and other spinal cord pathologies. It has been increasingly used off-label for the management of several disorders, including ...
pmc.ncbi.nlm.nih.gov
This study explains the symptoms, effect, and treatment of baclofen overdose. In general, ingestion as little as 200 mg a day could cause toxicity with the symptoms of degradation of consciousness (hallucinations, confusion, tremor, catatonia) that could lead up to death. Here's a case report of alleged ingestion of 15 tablet of 20 mg baclofen that ended on his death:
ctemourge
and by the time ur hearing this ill already b gone
- Aug 14, 2023
- 120
hey are you still answering these? my question is im on 2mgs lorazepam and have been for a couple months , i want to up my dose but my doctor says she cant perscribe more. if i self medicate with 2.5 or 4mgs will that be okay? as much as i want to ctb im not ready to commit to that yet
I don't think that's a possible ways to CTB. At the very least, not peaceful enough because you need high amounts of suppositories to do that.
What is the reason to increase the dose? I kinda need to know before I gave that advice.Hey, I have a few prescription meds available and was thinking about CTB. What do you think my chances are with 50mg oxycodone, 25mg lorazepam, 50mg codeine and 500ml of vodka all at once? And also how would i stop myself from throwing everything up and wasting it?
interna
Gone Tomorrow, Here Today
- Dec 1, 2025
- 67
do you think, for a smaller framed person, dying of serotonin syndrome be achievable with 1300mgs of zoloft? or would i get intoxicated and that's it
Good combination of depressants with all of them can interact with each other. I think you can ctb using this method, that is if you ingest all of them at the same time because most of them have crazy onset time.
As for to stop vomiting, I recommend to stop eating anything 1-2 hours before you ingest all of the meds. It's even better if you take antiemetic beforehand like in most of SN methods.
I think it can, but the risk is too much for ctb to succeed. Sertraline (Zoloft) is an SSRI, which slow to absorb and slow to take effect. It can be used as an adjunct to other methods since SSRI inhibits CYP in your liver and therefore it can increase other drugs concentration in blood. But for a solo method? I highly don't recommend that.Last edited:
nitrogenous
Just wanna break free of all suffering
- Dec 26, 2025
- 117
I'm very prone to vomiting as I have had history of overdosing before. I'm planning to ctb using SN this time and I already have the SN. As of now, I have 7 diazepam (5mg each) tablets, ondansetron and the SN itself. I have just ordered meto as I heard it works differently from ondansetron. I have a question, people say that Xanax is way better than Diaz, but I have no idea how to obtain this. I am also unsure about the recommended dose on the PPeH as 50 tablets of Diaz sounds a lot and I feel like it would make me vomit or pass out instead. What are your thoughts in regards to this? Thanks!
interna
Gone Tomorrow, Here Today
- Dec 1, 2025
- 67
do yiu think overdosing on paracetamol would be a better option? i have around 3500+ mg, idk wgat the lethal dose is nor if itd be a quick death or what.
ShadowedChaos
LostSoul
- Oct 2, 2024
- 47
I've done a lot of research myself and I'm sort of unsure if this method is viable. I also have some seroquel which I could add to this mix and might even have some more of these medications I would have to double check but if I decided to take either the mirtazapine or the the seroquel mainly for the sleep part or when I start getting tired go and then start taking all the medications whats the likelihood I'd wake up. Or if not do you think id get more drowsy before the other effects started to kick in. I'm mainly nervous about the dxm part of it because I know at that level it can be deadly which is fine but id rather not survive and be in a multi day dissociative episode while dying or feeling like im dying. While there are some reports I can find on sites like erowid or reddit of people doing 1500 mg or 1000 mg most of them don't have great experiences or there just isn't a lot of information. I know since I also am underweight for my height and age that it should also hit me harder and plus most of those people used DXM a lot. Idk if you have any questions let me know I read a lot about the interactions and just singularly for each med but I thought it would be worth a shot to at least ask. Also reading about serotonin syndrome it sounds really miserable so I'm worried about that I know these meds usually aren't super heavy on it but at this amount is that a possibility id have to worry about it. 35 Auvelity(45mg DXM 105mg bupropion), 90 hydroxyzine(50mg), 35 mirtazapine(7.5mg)So if I was to down 300 30mg codeine tablets with a bottle or morphine and vodka am I just gonna throw up, wake up severely injured/in pain or finally die?
ShadowOfASelf
Member
- Feb 10, 2026
- 48
Would Everclear change the calculation for lethality if mixed with like benzodiazipines, zopiclone and prazosin and other things of that nature? Putting vomiting aside, let's say that doesn't happen. Also Benadryl, I know by itself it causes terrible hallucinations and likely not death but would combining it with the above or any mix of us above be lethal?
Because Everclear seems pretty available to me where I live. or maybe combined with partial hanging
NameOfAction
Do as I say, not as I do
- Feb 12, 2026
- 99
I'm done with my psychiatrist due to costs and little to no improvement, so I'm basically now prescribing myself.
Lamotrigine 100mg carefully titrated over 3 weeks enough for BPD mood stability? I thought about adding Venlafaxine due to crippling depression, but I might be a risk for mania, so lamo first, then carefully Ven. I have lithium, but I'm deathly afraid of toxicity and have no way to monitor blood levels
Any ideas? Most SSRIs have been tried with only temporary benefit. I'm honestly kinda desperate for immediate improvement due to suicidal plans and urges, but nothing short of Ketamine offers immediate improvement, as far as I'm aware. I don't have access to controlled substances, including stimulants
I'm not @MatiSendiri , but please read the pinned thread on non-methods.
Overdose of over-the-counter meds, psychiatric meds, pretty much any meds excluding strong opioids or benzos will not kill you! (most likely)
Read the pinned posts on methods or read The peaceful pill handbook, Final Exit (I can share copies if you can't find them) for viable methods.
Trying to od on SSRIs or paracetamol is like trying to od on table salt. Technically archivable, highly undesirable and carries a very high chance of injury and survival (only about 5% of medication overdoses end in death)Last edited:
anomic
A single angel can make a world of demons bearable
- Dec 13, 2025
- 57
I would like to preface I am in no way a doctor and I do not have any sort of qualifications however I'll use my very limited knowledge to try and help a bit (and please fact check for yourself on top of this)
100mg of lamotrigine is likely insufficient. According to some clinical data I have gathered, the dosage you should be aiming for with lamotrigine to treat bipolar (BPD as I will refer to it now on) is typically around 200mg per day [1]. Typical titration with lamotrigine week by week is as follows 25mg, 50mg, 100mg, 200mg (and maintenance). Lamotrigine is mainly effective when used for maintenance treatment rather than acute episodes, and 100mg would be on your lower end of your targeted therapeutic dosage [2].
You are correct! That combination requires some major caution to be taken. Research has revealed that there is a significantly noticeable increase in the risk of switching between hypomania or mania in patients that are being treated with venlafaxine rather than bupropion or sertraline [3]. The order you proposed (lamotrigine first, then venlafaxine) is a reasonable start for monitoring. However, you should start venlafaxine at a very low dosage (37.5mg) and ensure that your lamotrigine is at a therapeutic dosage (200mg) before adding the venlafaxine. You need to make sure to very closely monitor for any sort of manic symptoms during this process to ensure you are staying safe.
This is honestly a very valid concern. Lithium has a very tiny therapeutic window (0.6-1.2 mEq/L for maintenance). And without being able to monitor your blood level, lithium could cause: thyroid dysfunction, renal impairment, and severe toxicity (resulting in tremor, confusion, seizures, and coma). While lithium remains an amazing way to treat BPD, it requires constant checkups. I couldn't possibly see myself recommending you to continue lithium without professional follow-ups [4].
Due to your past of failed SSRIs I have a small list to provide you with a few ideas:
- Quetiapine is the most often prescribed medication for bipolar depression (over 35% of patients according to hospital data) [4]
- Lurasidone (not much to say here but it's FDA approved for BPD if that means anything to you)
- Valproic acid (over 30% usage rate)
A final remark on ketamine: There are some studies that observe quick antidepressant effects, it has its own risks and I wouldn't recommend it without medical supervision.
Again I am not a doctor and I am not the OP but I decided hey why not take a shot at possibly helping. Anyways I hope at least most of this was correct and as always, have an amazing day B)
and for @MatiSendiri please feel free to correct any and all of this info im super interested in anatomy and all of that but way too stupid to actually go to school for it
I've been trying to CTB for about two years now.
I have perfected a method that will get me to a location at least 160 feet above ground on a balcony with a fall straight onto concrete provided that I make a small leap from the railing. I hit my weed pen like 7 times to overcome SI but diddnt work. The time before that I used lorazepam but that diddnt work either as I just fell asleep.
The next time I can access that location is in 3-4 weeks, i think alcohol is the next move for me.
Thoughts?
Basically anything that makes me go unconscious even for a second so I can fall backwards. Helium? Anisthesia? Idk
Yes Xanax is actually far stronger with slightly longer onset than diazepam so it could be used as a faster, more reliable adjustments to diazepam.
Source: https://benzoreform.org/comparison-of-benzodiazepine-pharmacology/
According to calculation, 15 mg of oxazepam is equal to 10 mg of diazepam which is equal to 0,5 mg of alprazolam. So if PPEH recommends 20x30 mg oxazepam, you only need around 40 0,5 mg of Alprazolam or around 20 1 mg tablet, which is smaller and hopefully easier for you to swallow
Since Xanax is a controlled substance, I don't really know how you can get it. But you can find alternatives using its generic form (Alprazolam) to basically get the same effect.
Don't even bother, paracetamol sucks to use as a CTB method. You might as well do other methods than that.
I'm really sorry about this but my English isn't that good. I've been reading this for about 30 minutes and I still don't get what you're saying.
Please share your clear methods of ctb and I'll review it. If you're uncomfortable, my DM is always open. Thanks.
I do use lamorigine (Lamictal) and SSRI (Fluoxetine) rn, so I get your fears about that medication.
Acute treatment isn't what you need tbh. I think your condition can also be included as psychotic depression since your mood is instable and frequently have thoughts to ctb. Antipsychotics (such as aripiprazole) can be used to treat this and keep it maintained. As for acute one, I really suggest you go to the ED and get ketamine.
I like your answers. Quite on point with slight correction on lamotrigine dose. I understands that his lamotrigine dose is at the lower end of the treatment, but I also undestand that this is his self-medication and I heavily expects him to have fewer resources on medication. I really suggest to add antipsychotics (such as quetiapine in your recommendation) and other medication to complement his lower dose of lamotrigine.
If you think my reply needs correction too, feel free to do it! Thanks for helping me!
I already reply this in private conversation. Please check there. Thanks!Last edited:What would happen if I took two to three bottles of flexeril? Is there risk of serotonin syndrome? What if I mixed it with olanzapine?
I have some old amitriptyline but I hear that's slow and painful, probably would need more than I have.
Do you know anything about iatrogenic injury from medication? I feel like olanzapine really screwed me over in many ways.Last edited:
Porgierot
Member
- May 27, 2025
- 9
I've had some attempts with amitriptyline, though they were fairly impulsive and I ended up panicking myself out of them. Entered coma both times, I'm curious about the painfulness as I haven't ever seen that much talk about it at all nor heard from a lot of others on it. When would that pain come? Would such a coma just continue til you die or are you likely to wake up at some point and be in pain? I've been told my previous 2.5g dose was likely to kill me if I hadn't been in the hospital and I have more than double of it now if I end up giving it a better try, but very curious about the pain mentioned as I wasn't in pain when I ODed on them.Similar threads
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