Discussion Medication/Substance Thread

[MatiSendiri]

Hi, I'm a pharmacy student and I'd like to answer your question about medication or substance. Ask anything really, and I answer it. I would also try as much as possible to post the source of my answer so you can explore more about that.

Why would I do this? Idk tbh. I was just bored and maybe I can help people in here. I'm also suffering from depression and still on my meds rn. There's definitely times when I feel really suicidal but situation has put me better rn.

If there's any professional here that'll notice that my answer is wrong, please correct it. I don't mind really. That's all, can't wait for your question.

 

[Freedomm]

I need to know the maximum dose of chloropyramine that suppresses the central nervous system without strong side effects. As far as I know, antihistamines in high doses suppress the vomiting center.

 

[MatiSendiri]

I need to know the maximum dose of chloropyramine that suppresses the central nervous system without strong side effects. As far as I know, antihistamines in high doses suppress the vomiting center.

This is pretty hard for me to find since chloropyramine is only used in Eastern Europe and very much easy to mistaken with chlorpheniramine in English studies. Since I can't really speak languages around Eastern Europe its pretty hard for me to get some research around chloropyramine. Here's what I found:

https://dspace.nuph.edu.ua/bitstream/123456789/11670/1/221(1).pdf

From here we found out that LD50 (lethal dose to kill at least 50% of the population) of chloropyramine is 920 mg/kg. Using this thread (https://www.bluelight.org/community/threads/how-to-translate-ld50-from-rats-mice-to-humans.923749/) we can found out that the LD50 for humans is around 74,52 mg/kg. Now is this accurate? Kinda, but you could read this paper to get more knowledge regarding LD50 in humans and rats: https://sci-hub.ru/https://doi.org/10.1177/0261192921994754

As for the side effects, here's the tricky part. We already estabilished the upper limit for you to consume by getting its LD50. But suppressing the CNS is the side effect of antihistamine. Each people have different side effects or tolerance to any of the drug, including chloropyramine. I'd suggest for you to try it yourself starting with the lowest dose possible until you found out the right dose for you to be drowsy and stop vomiting.

 

[SuicideKurt]

What drugs increase the chance of NDE at death?

 

[Fall_Apart]

I've been taking benzos for over 30 years, and for the last six, I've also been taking Lexapro. I can't reduce these medications because the withdrawal is driving me crazy. I tried doubling the Lexapro, but even then, I had a withdrawal-like crisis. The problem is that Lexapro is making me more and more like a robot, but I'm screwed now. Do you think increasing the Lexapro dose can stabilize after a period of withdrawal?

 

[cazza82]

Hi, I'm a pharmacy student and I'd like to answer your question about medication or substance. Ask anything really, and I answer it. I would also try as much as possible to post the source of my answer so you can explore more about that.

Why would I do this? Idk tbh. I was just bored and maybe I can help people in here. I'm also suffering from depression and still on my meds rn. There's definitely times when I feel really suicidal but situation has put me better rn.

If there's any professional here that'll notice that my answer is wrong, please correct it. I don't mind really. That's all, can't wait for your question.

Could the sleeping pill zopiclone work to ctb if a lot is used

 

[MatiSendiri]

What drugs increase the chance of NDE at death?

Psychedelics. Usually the stronger one will increasing the chance and effects of NDE itself. Here's a case study of a man who experience NDE with a psychedelics: https://pmc.ncbi.nlm.nih.gov/articles/PMC10345338/. There's also a study conducted towards 36 people whose ingested DMT up to a dose near the NDE: https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2025.1532937/full#SM1.

Both of them also contain the experience of the NDE so its interesting if you want to learn more about NDE in general

I've been taking benzos for over 30 years, and for the last six, I've also been taking Lexapro. I can't reduce these medications because the withdrawal is driving me crazy. I tried doubling the Lexapro, but even then, I had a withdrawal-like crisis. The problem is that Lexapro is making me more and more like a robot, but I'm screwed now. Do you think increasing the Lexapro dose can stabilize after a period of withdrawal?

Better option is to withdraw over a long periods of time so that you can tolerate the decreasing dose tolerably. Although Lexapro (escitalopram) is a low-risk drug in terms of withdrawal, your case of withdrawal even when taking the medicine (which counted as a rebound) should be treated differently simply due to how each people will have different experience when treated with antidepressants.

Here's a study if you want to learn more about the withdrawal of antidepressants: https://pmc.ncbi.nlm.nih.gov/articles/PMC6637660/#E18

Here's a case report of tapered withdrawal of Lexapro which shows that the patient when following the withdrawal shows minimal to mild withdrawal severity: https://www.sciencedirect.com/science/article/pii/S2773021222000098

Do note that if you plan to withdraw at least talk to your doctors so they can make a plan on to your withdrawal from Lexapro.

Could the sleeping pill zopiclone work to ctb if a lot is used

Yes actually. There is a interesting report of death by zopiclone in Sweden:

Fatal Intoxications with Zopiclone—A Cause for Concern? - PMC

Zopiclone, a controlled substance prescribed for insomnia, has become a common toxicological finding in forensic autopsy cases. This study investigated the role and extent of zopiclone use in fatal intoxications in Sweden. All forensic autopsy cases ...

pmc.ncbi.nlm.nih.gov

Basically in 8 years of the study (2012-2020), there is 573 zopiclone related deaths, 354 (62%) is ruled suicide. Sadly there is no definitive report on how much is needed to ctb or how long to ctb by using zopiclone. But from that report, we can found out that zopiclone can work using alone or with other substance (the most is alcohol in the study).

Now, my motto for ctb is to be as quick and as painless as possible. Sadly though, death by medicine can be risky due to it isn't that quick to make ctb so that you can be found and still alive with organ failure. If you still consider using zopiclone, please plan your ctb as thorough as possible.

 

[SuicideKurt]

Psychedelics. Usually the stronger one will increasing the chance and effects of NDE itself. Here's a case study of a man who experience NDE with a psychedelics: https://pmc.ncbi.nlm.nih.gov/articles/PMC10345338/. There's also a study conducted towards 36 people whose ingested DMT up to a dose near the NDE: https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2025.1532937/full#SM1.

Both of them also contain the experience of the NDE so its interesting if you want to learn more about NDE in general

Better option is to withdraw over a long periods of time so that you can tolerate the decreasing dose tolerably. Although Lexapro (escitalopram) is a low-risk drug in terms of withdrawal, your case of withdrawal even when taking the medicine (which counted as a rebound) should be treated differently simply due to how each people will have different experience when treated with antidepressants.

Here's a study if you want to learn more about the withdrawal of antidepressants: https://pmc.ncbi.nlm.nih.gov/articles/PMC6637660/#E18

Here's a case report of tapered withdrawal of Lexapro which shows that the patient when following the withdrawal shows minimal to mild withdrawal severity: https://www.sciencedirect.com/science/article/pii/S2773021222000098

Do note that if you plan to withdraw at least talk to your doctors so they can make a plan on to your withdrawal from Lexapro.

Yes actually. There is a interesting report of death by zopiclone in Sweden:

Fatal Intoxications with Zopiclone—A Cause for Concern? - PMC

Zopiclone, a controlled substance prescribed for insomnia, has become a common toxicological finding in forensic autopsy cases. This study investigated the role and extent of zopiclone use in fatal intoxications in Sweden. All forensic autopsy cases ...

pmc.ncbi.nlm.nih.gov

Basically in 8 years of the study (2012-2020), there is 573 zopiclone related deaths, 354 (62%) is ruled suicide. Sadly there is no definitive report on how much is needed to ctb or how long to ctb by using zopiclone. But from that report, we can found out that zopiclone can work using alone or with other substance (the most is alcohol in the study).

Now, my motto for ctb is to be as quick and as painless as possible. Sadly though, death by medicine can be risky due to it isn't that quick to make ctb so that you can be found and still alive with organ failure. If you still consider using zopiclone, please plan your ctb as thorough as possible.

So do I understand you correctly in order to increase my chance of NDE while CTB it's better to smoke DMT? I've heard and my personal experience was that psilocybin mushrooms deeply affected my time and one minute was feeling like one hour to me. Does that gonna make my NDE longer?

 

[MatiSendiri]

So do I understand you correctly in order to increase my chance of NDE while CTB it's better to smoke DMT? I've heard and my personal experience was that psilocybin mushrooms deeply affected my time and one minute was feeling like one hour to me. Does that gonna make my NDE longer?

I mean based on the study yeah DMT is the best option to have NDE while CTB. But then again, psychedelic experiences can vary wildly between person to person (like in the second study) so if you are comfortable with psilocybin and like its time-altering effect go ahead.

 

[Daphne]

Hi, I'm a pharmacy student and I'd like to answer your question about medication or substance. Ask anything really, and I answer it. I would also try as much as possible to post the source of my answer so you can explore more about that.

Why would I do this? Idk tbh. I was just bored and maybe I can help people in here. I'm also suffering from depression and still on my meds rn. There's definitely times when I feel really suicidal but situation has put me better rn.

If there's any professional here that'll notice that my answer is wrong, please correct it. I don't mind really. That's all, can't wait for your question.

Hello, thanks for sharing your knowledge. Do pharmacies in the US carry barbituates? What is the strongest narcotic one would find in an American pharmacy?

 

[MatiSendiri]

Hello, thanks for sharing your knowledge. Do pharmacies in the US carry barbituates? What is the strongest narcotic one would find in an American pharmacy?

I'm an Indonesian so I can't really answer that question. However, from what I can found fentanyl is still the strongest narcotics in the US pharmacy (with prescription of course):

The Most Potent (Strongest) Opioids Currently Available

Opioid use disorders still develop even under a doctor’s supervision. Read on to learn about some of the strongest opioids available today.

delphihealthgroup.com

From what I can found, barbiturates are still being sold in US pharmacy. There is no specific article about what type of barbiturates is in US pharmacy though.

 

[Jisatsu]

A dumb question but what would happen to the human body if it ingested 24,000 mg of aspirin in one sitting?.

 

[MatiSendiri]

A dumb question but what would happen to the human body if it ingested 24,000 mg of aspirin in one sitting?.

Sorry for the really late reply but here's how it goes.

Assume that the human weighs 70 kg. 150–200 mg/kg of aspirin produce mild intoxication and 300–500 mg/kg will produce severe intoxication (Olson's Poisoning & Drug Overdose). With 70 kg, there's around 350 mg/kg of aspirin in the body, enough to produce severe intoxication.

The symptom will goes as follows according to Olson's Poisoning:
1. Vomiting occurs shortly after ingestion, followed by hyperpnea (faster breathing), tinnitus, and lethargy.
2. Mixed respiratory alkalemia and metabolic acidosis are apparent when blood gases are determined.
3. With severe intoxication, coma, seizures, hypoglycemia, hyperthermia, and pulmonary edema may occur.
Death is caused by CNS failure and cardiovascular collapse.

If you want to read more about this, here's a case report for the 23 yo woman whose ingested 250 aspirin tablets in one sitting:

Sci-Hub : {title} [{doi}]

Also, daily bump for today. Maybe I'll bump daily in case there's no question for a day lmao.

 

[metothemoon]

Is it worth trying to OD with nortriptilin or will it only be painful? And how much to take?

 

[abyss.all]

I plan on ctb via full suspension, my main concern is the anxiety spike when my body realizes it cannot intake air anymore. I know theres a slight amt of pain, but its neglegable compared to others methods. Would xans + an over the counter pain killer be the best in this case? Im broke, and very inexperienced, so the drugs being accessable and cheap is a factor. Thanks!

 

[MatiSendiri]

Is it worth trying to OD with nortriptilin or will it only be painful? And how much to take?

Generally speaking, OD with antidepressants is not worth it at all. Most modern antidepressants have been made to at least hamper suicidal patients to use them.

That said, nortriptyline belong into trycyclic antidepressants which have short therapy index. According into Olson's Poisoning & Drug Overdose, doses of less than 10 times the therapeutic daily dose may produce severe intoxication. Since nortryptiline have therapeutic dose of 75–150 mg/kg, we can rough the number up into 750-1500 mg/kg. But in general, ingestion of 10–20 mg/kg of some tricyclic antidepressants is potentially life-threatening.

What are the symptoms? Here's how it goes:
A. Cardiovascular effects. Several mechanisms contribute to cardiovascular toxicity:
1. Anticholinergic effects and inhibition of neuronal reuptake of catecholamines result in tachycardia and mild hypertension.
2. Peripheral alpha-adrenergic blockade causes vasodilation and contributes to hypotension.
3. Membrane-depressant (quinidine-like) effects cause myocardial depression and cardiac conduction disturbances by inhibition of the fast sodium channel that initiates the cardiac cell action potential. Metabolic or respiratory acidosis may contribute to cardiotoxicity by further inhibiting the fast sodium channel.
B. Central nervous system effects. These effects result in part from anticholinergic toxicity (eg, sedation and coma), but seizures are probably a result of inhibition of reuptake of norepinephrine or serotonin in the brain or other central effects.

Tldr: It usually affects CNS and cardiovascular with dysfunction of the heart and coma if they're led long enough.

Here's a case report of this if you're interested:

Sci-Hub. Nortriptyline Abuse: A Case Report and Review of the Literature / Clinical Neuropharmacology, 2019

Sci-Hub. Toxicokinetics of Nortriptyline and Amitriptyline: Two Case Reports / Therapeutic Drug Monitoring, 2003

I plan on ctb via full suspension, my main concern is the anxiety spike when my body realizes it cannot intake air anymore. I know theres a slight amt of pain, but its neglegable compared to others methods. Would xans + an over the counter pain killer be the best in this case? Im broke, and very inexperienced, so the drugs being accessable and cheap is a factor. Thanks!

Xanax (alprazolam) works extremely fast, around 15-30 minutes after ingesting it:

https://downloads.asam.org/sitefinity-production-blobs/docs/default-source/guidelines/benzodiazepine-tapering-2025/pharmacokinetic-properties-of-benzodiazepines.pdf?sfvrsn=91bb2577_1

So yeah maybe you could try to experiment yourself. Imo there's a lot to prepare in terms of medication:
1. Know how your onset time of Xanax to be the more prepared. I'd suggest having a timer from the start of you drinking it up to the time you experience its effects. Might be more better if you record yourself from the start instead of a timer since you may experience drowsiness or outright sleeping after you experience Xanax.
2. Try which OTC painkiller is the best option for you in terms of availability and its effect. Usually OTC painkiller is weaker than prescription one. But also I'm from Indonesia so I can't really judge your medication availabiliy there.
3. Know the onset of your chosen painkiller. Do the same as to Xanax, but maybe test its painkilling effect by sh.

The problem is that imo there's a lot to prepare on hanging yourself. This maybe really OOT for this one, but I found a good topic of full suspension (and hanging in general) made by people in SaSu here. Here's the link:

https://i.sanctioned-suicide.net/images/2024/01/185369_2023_Full_Suspension_102_-_a_guide.pdf

Remember, if you plan to ctb, make sure to at least plan this as thorough as possible with the resource you have. Be quick and be painless on your ctb so that you don't regret it in the future.

 

[bankai]

What can you say about amyl nitrite poppers?At a purity of 95%, do you think that they are lethal enough when ingested? What do you think the experience will be like and how long do you think it will take for the person to pass?

 

[MatiSendiri]

What can you say about amyl nitrite poppers?At a purity of 95%, do you think that they are lethal enough when ingested? What do you think the experience will be like and how long do you think it will take for the person to pass?

They can be lethal, but that doesn't mean that they can be used for ctb. Since nitrite is a vasodilator, the effects usually follow the lines of:
1. Hypotension, usually shown with headaches, tachycardia (low blood pulse), and dizziness.
2. Methemoglobinemia (lack of hemoglobin that carry oxygen in the blood) usually shown by blue skin of the affected
3. Tolerance into angina if they can be consumed long enough/chronic usage.

Here's a really interesting paper about the usage of popper in the UK. From 1971–2009 only 23 deaths can be caused by poppers, so its really rare and can be treated fast enough if you are found:

An Update on Deaths in the United Kingdom from ‘Poppers’ (Alkyl Nitrites), with a Particular Focus on ‘Swallowing’ Fatalities - PMC

Background/Objectives: Alkyl nitrites are a class of inhalant, commonly known as ‘poppers’. Although having medical uses, some other effects include a ‘rush’, ‘high’, ‘euphoria’, or feeling of excitement. This has led to their recreational use, in ...

pmc.ncbi.nlm.nih.gov

 

[SuicideKurt]

SI question: What are the best benzos to take to calm SI down? Does it make sense to take benzos say a week before CTB or will it reduce the effect?

 

[cowplantabduction]

Could a sertraline/zoloft overdose be a viable method of CTB if that's all someone has? Around how much would you need to ingest?

 

[tapetum_lucidum]

How much testosterone would I need to inject into my veins to kill me

 

[metothemoon]

Generally speaking, OD with antidepressants is not worth it at all. Most modern antidepressants have been made to at least hamper suicidal patients to use them.

That said, nortriptyline belong into trycyclic antidepressants which have short therapy index. According into Olson's Poisoning & Drug Overdose, doses of less than 10 times the therapeutic daily dose may produce severe intoxication. Since nortryptiline have therapeutic dose of 75–150 mg/kg, we can rough the number up into 750-1500 mg/kg. But in general, ingestion of 10–20 mg/kg of some tricyclic antidepressants is potentially life-threatening.

What are the symptoms? Here's how it goes:
A. Cardiovascular effects. Several mechanisms contribute to cardiovascular toxicity:
1. Anticholinergic effects and inhibition of neuronal reuptake of catecholamines result in tachycardia and mild hypertension.
2. Peripheral alpha-adrenergic blockade causes vasodilation and contributes to hypotension.
3. Membrane-depressant (quinidine-like) effects cause myocardial depression and cardiac conduction disturbances by inhibition of the fast sodium channel that initiates the cardiac cell action potential. Metabolic or respiratory acidosis may contribute to cardiotoxicity by further inhibiting the fast sodium channel.
B. Central nervous system effects. These effects result in part from anticholinergic toxicity (eg, sedation and coma), but seizures are probably a result of inhibition of reuptake of norepinephrine or serotonin in the brain or other central effects.

Tldr: It usually affects CNS and cardiovascular with dysfunction of the heart and coma if they're led long enough.

Here's a case report of this if you're interested:

Sci-Hub. Nortriptyline Abuse: A Case Report and Review of the Literature / Clinical Neuropharmacology, 2019

Sci-Hub. Toxicokinetics of Nortriptyline and Amitriptyline: Two Case Reports / Therapeutic Drug Monitoring, 2003

Xanax (alprazolam) works extremely fast, around 15-30 minutes after ingesting it:

https://downloads.asam.org/sitefinity-production-blobs/docs/default-source/guidelines/benzodiazepine-tapering-2025/pharmacokinetic-properties-of-benzodiazepines.pdf?sfvrsn=91bb2577_1

So yeah maybe you could try to experiment yourself. Imo there's a lot to prepare in terms of medication:
1. Know how your onset time of Xanax to be the more prepared. I'd suggest having a timer from the start of you drinking it up to the time you experience its effects. Might be more better if you record yourself from the start instead of a timer since you may experience drowsiness or outright sleeping after you experience Xanax.
2. Try which OTC painkiller is the best option for you in terms of availability and its effect. Usually OTC painkiller is weaker than prescription one. But also I'm from Indonesia so I can't really judge your medication availabiliy there.
3. Know the onset of your chosen painkiller. Do the same as to Xanax, but maybe test its painkilling effect by sh.

The problem is that imo there's a lot to prepare on hanging yourself. This maybe really OOT for this one, but I found a good topic of full suspension (and hanging in general) made by people in SaSu here. Here's the link:

https://i.sanctioned-suicide.net/images/2024/01/185369_2023_Full_Suspension_102_-_a_guide.pdf

Remember, if you plan to ctb, make sure to at least plan this as thorough as possible with the resource you have. Be quick and be painless on your ctb so that you don't regret it in the future.

Thank you! Will it have long lasting effects when I OD on TCA? Or will I just pass out for a couple of days. Cause I can really use that right now..

 

[Jisatsu]

They can be lethal, but that doesn't mean that they can be used for ctb. Since nitrite is a vasodilator, the effects usually follow the lines of:
1. Hypotension, usually shown with headaches, tachycardia (low blood pulse), and dizziness.
2. Methemoglobinemia (lack of hemoglobin that carry oxygen in the blood) usually shown by blue skin of the affected
3. Tolerance into angina if they can be consumed long enough/chronic usage.

Here's a really interesting paper about the usage of popper in the UK. From 1971–2009 only 23 deaths can be caused by poppers, so its really rare and can be treated fast enough if you are found:

An Update on Deaths in the United Kingdom from ‘Poppers’ (Alkyl Nitrites), with a Particular Focus on ‘Swallowing’ Fatalities - PMC

Background/Objectives: Alkyl nitrites are a class of inhalant, commonly known as ‘poppers’. Although having medical uses, some other effects include a ‘rush’, ‘high’, ‘euphoria’, or feeling of excitement. This has led to their recreational use, in ...

pmc.ncbi.nlm.nih.gov

What if you pur some out into a bag and huff it for a minute or two , it wouldn't be as dangerous as just ingesting and if you do it that way im pretty sure you'd loss consciousness pretty fast because of the lack of oxygen.

 

[MatiSendiri]

SI question: What are the best benzos to take to calm SI down? Does it make sense to take benzos say a week before CTB or will it reduce the effect?

Do note that most of the here is my opinion. The best benzos to calm you SI is:
1. Have fast onset, but not fast enough so that you can't prepare your ctb
2. Have big enough effects (usually can be increased by increasing its dose)
3. Available enough to be purchased

Same as before, you could refer to this chart:

https://downloads.asam.org/sitefinity-production-blobs/docs/default-source/guidelines/benzodiazepine-tapering-2025/pharmacokinetic-properties-of-benzodiazepines.pdf?sfvrsn=91bb2577_1

Here's how to prepare it:
1. Time out how much time you need to prepare your ctb. Increase your time expectation due to your panic or your mood if you experience that while you are training.
2. Time out how much time you need to experience your chosen benzo. Remember on the chart above onset time is how much time passes from you taking the meds into its effect, while peak plasma refer into how much time passes from you taking the meds into its highest concentration in your plasma.
3. Unless you're timing, don't use benzo for a week unnecessarily. Using it chronically can make you tolerant in benzo so that you might not have the same effect with the same repeated dose.

The best benzo to take is Alprazolam (Xanax). It have fast onset (but not fast enough as diazepam/Valium), have good effects, and usually available in pharmacy. Do adjust it if that wasn't available in your condition.

Could a sertraline/zoloft overdose be a viable method of CTB if that's all someone has? Around how much would you need to ingest?

Do not take antidepressants to CTB. Its not worth it at all. Nearly all of antidepressant have really long therapeutic index (gap between therapeutic dose and toxic dose). If you want to learn more, please read this paper:

Selective Serotonin Reuptake Inhibitors and Adverse Effects: A Narrative Review - PMC

Depression is the most prevalent psychiatric disorder in the world, affecting 4.4% of the global population. Despite an array of treatment modalities, depressive disorders remain difficult to manage due to many factors. Beginning with the ...

pmc.ncbi.nlm.nih.gov

The pharmacokinetics of sertraline in overdose and the effect of activated charcoal - PMC

To investigate the pharmacokinetics (PK) of sertraline in overdose and the effect of single dose activated charcoal (SDAC). Patients presenting to a toxicology unit with sertraline overdoses had demographic and clinical information recorded, and ...

pmc.ncbi.nlm.nih.gov

But if you really want to do, toxic dose of sertraline is not really estabilished. Here's a case report of a man whose successfully ctb using Xanax and Zoloft at the same time:

https://www.researchgate.net/publication/13496920_Fatal_Multiple_Drug_Intoxication_Following_Acute_Sertraline_Use

If there's one drug that I recommend to use for ctb, its the opposite of the the antidepressant, depressant drug. It includes the drug that both depresses your bodily function and your brain, making it extremely useful for turning off your SI and make sure that your heart stops forever. It can be used in combination to ctb (like turning off your SI) or as a method of ctb if used in a large dose.

Depressant - Wikipedia

en.wikipedia.org

Depressants - Alcohol and Drug Foundation

Learn how depressant drugs slow down your central nervous system and affect your body and mind. Explore different types, potential dangers, and signs of dependence.

adf.org.au

There's 5 types of drugs that I want to talk here:
1. Alcohol: Extremely available, but not lethal if fast enough. Use it in conjunction to other methods of ctb (like hanging yourself or SN)
2. Benzodiazepines: Less available, more stronger than alcohol with faster onset. Can be lethal enough to make use of their own.
3. Z drug: New candidate, more or less same as benzo. Can be lethal enough to make use of their own.
4. Opioid: Can be really hard. Strong but not worth it imo.
5. GHB, cannabis, and the others isn't really explored as a method of ctb so use it with caution

How much testosterone would I need to inject into my veins to kill me

I can't really answer this question since there's no experiment involving sudden increase in testosterone can cause sudden death. There's a related paper showing chronic use of testosterone that kill a 28 year old bodybuilder:

Sudden cardiac testosterone-related death involving a young bodybuilder: autopsy, histopathological and toxicological findings - Egyptian Journal of Forensic Sciences

Background Anabolic androgenic steroids (AASs) comprise a large group of synthetic derivatives of testosterone, designed to enhance anabolic properties while minimizing androgenic effects. In addition to their therapeutic applications, AASs are frequently abused by athletes, particularly...

ejfs.springeropen.com

But so far, research on testosterone really focuses on its long term effects, either on its effects or its risks. I'd suggest for you to search alternative methods for ctb please.

Thank you! Will it have long lasting effects when I OD on TCA? Or will I just pass out for a couple of days. Cause I can really use that right now..

Honestly that really depends on how much time you are found out by the medics. Can you die by using TCA (tricyclic antidepressants)? Certainly, usually around 24 hours of you ingesting it its really guaranteed that you'll dead. But that'd so painful because you are slowly losing your CNS and your heart function which can be permanent even if you recovered later on. And don't even started on liver and kidney damage since you are basically consuming poison with large dose.

If you want to get high, there's a lot of other choices than TCA. If you want to ctb, there's a lot of other choices than TCA. Don't make that kind of pain to yourself.

What if you pur some out into a bag and huff it for a minute or two , it wouldn't be as dangerous as just ingesting and if you do it that way im pretty sure you'd loss consciousness pretty fast because of the lack of oxygen.

Not the best option. Huffing (inhalation) is the worst way to ingesting something into your blood system and the effect can only make you pass out at max. Not only that it makes it easier for you to be found and resuscitated, even if you've successfully managed to deprive your brain long enough for you to lose consciousness permanently, you are basically just brain dead/in a coma. If you have nearby people whose still love you, rest assured that they'll fight as much as possible to bring you back here.

 

[lasttogo]

I have a question if you don't mind. Prazosin. I don't see it talked about a lot here in terms of ctb. Let's say someone has slightly low blood pressure all the time, and already knows that >5 tablets (not sure what the measurement is, 1 something each) causes them to pass out. Is there a viable method there somewhere? What is the prazosin actually doing?


And then safety question unrelated to ctb - is it safe to take Ativan and prazosin at the same time?

 

[MatiSendiri]

I'm really sorry for not active and not answering anyone's question today. I've catched a cold since this morning combined with some college work to do today. However I'll bump this thread so if anyone has any questions you can ask her and hopefully I'll answer those tomorrow. Cheers!

 

[MatiSendiri]

I have a question if you don't mind. Prazosin. I don't see it talked about a lot here in terms of ctb. Let's say someone has slightly low blood pressure all the time, and already knows that >5 tablets (not sure what the measurement is, 1 something each) causes them to pass out. Is there a viable method there somewhere? What is the prazosin actually doing?


And then safety question unrelated to ctb - is it safe to take Ativan and prazosin at the same time?

Data about toxicity of prazosin is very rare, even so about ctb using that. Most of the toxic case report that I found had the patient combine prazosin with other substance. As for the dose, toxic doses are documented as ranging from 285 mcg/kg (lowest reported dose) to 1.7 mg/kg on the Material Safety Data Sheet. Here's a case report about the toxicity of prazosin and the Material Data Sheet mentioned:

Sci-Hub. Refractory Hypotension Caused by Prazosin Overdose Combined With Acetaminophen and Naproxen Toxicity: A Case Report and Review of the Literature / The Journal of Emergency Medicine, 2018

https://cdn.caymanchem.com/cdn/msds/15023m.pdf

In my opinion, ctb using prazosin is possible, but not documented enough. Especially given your low tolerance on prazosin and low bp all the time. What I'd suggest is to combine them with other substance/method just to be sure that you'll dead later on.

As for Ativan (lorazepam) and prazosin question, the general answer is no. While there are no specific study focusing on Ativan and prazosin interaction, benzodiazepines (and sedatives in general) exhibit antihypertensive effects. Combined that with antihypertensives such as prazosin and your condition of low bp all the time makes the risk of hypotension is higher when consumed together. Do note that the effect of each drug can be different to each people, so what I'd suggest is to try Ativan and check your bp. If the bp drop after you consume it, don't combine them with prazosin since prazosin can drop the bp even lower. Here's the source:

Ativan and Minipress Interactions Checker - Drugs.com

A Moderate Drug Interaction exists between Ativan and Minipress. View detailed information regarding this drug interaction.

www.drugs.com

 

[lasttogo]

Data about toxicity of prazosin is very rare, even so about ctb using that. Most of the toxic case report that I found had the patient combine prazosin with other substance. As for the dose, toxic doses are documented as ranging from 285 mcg/kg (lowest reported dose) to 1.7 mg/kg on the Material Safety Data Sheet. Here's a case report about the toxicity of prazosin and the Material Data Sheet mentioned:

Sci-Hub. Refractory Hypotension Caused by Prazosin Overdose Combined With Acetaminophen and Naproxen Toxicity: A Case Report and Review of the Literature / The Journal of Emergency Medicine, 2018

https://cdn.caymanchem.com/cdn/msds/15023m.pdf

In my opinion, ctb using prazosin is possible, but not documented enough. Especially given your low tolerance on prazosin and low bp all the time. What I'd suggest is to combine them with other substance/method just to be sure that you'll dead later on.

As for Ativan (lorazepam) and prazosin question, the general answer is no. While there are no specific study focusing on Ativan and prazosin interaction, benzodiazepines (and sedatives in general) exhibit antihypertensive effects. Combined that with antihypertensives such as prazosin and your condition of low bp all the time makes the risk of hypotension is higher when consumed together. Do note that the effect of each drug can be different to each people, so what I'd suggest is to try Ativan and check your bp. If the bp drop after you consume it, don't combine them with prazosin since prazosin can drop the bp even lower. Here's the source:

Ativan and Minipress Interactions Checker - Drugs.com

A Moderate Drug Interaction exists between Ativan and Minipress. View detailed information regarding this drug interaction.

www.drugs.com

Thank you <3. I was more curious than interested in actually going this way and this is very good information. When I pass out on the prazosin it is honestly pretty terrifying so it makes sense there is not much documentation regarding ctb. I did not realize it was the medication the first time, and there was a very short period where I did wonder if I was dying or not. Unlike other times I've lost consciousness it felt like I HAD to fight my brain to stay inside my body or something very bad was going to happen. I went from standing and feeling fine, to on the ground. when I got back up I started to go again, and the "fight" began lol. Unpleasant for sure but that is where my curiosity came from.


I will definitely start taking my BP after I take Ativan in general. I am going through some stuff right now that's causing me to take it semi-regularly and I wonder if it is dropping my BP lower than it normally is, that would explain some things. I keep telling my doctor about my BP but they don't seem to be actually taking it in to account when they are giving me medications lol. I have recently realized (after the prazosin fiascos) that I have to specifically ask them to tell me the dangers/side effects I guess thank you again for the information and time you took to respond to me.

 

[MatiSendiri]

Thank you <3. I was more curious than interested in actually going this way and this is very good information. When I pass out on the prazosin it is honestly pretty terrifying so it makes sense there is not much documentation regarding ctb. I did not realize it was the medication the first time, and there was a very short period where I did wonder if I was dying or not. Unlike other times I've lost consciousness it felt like I HAD to fight my brain to stay inside my body or something very bad was going to happen. I went from standing and feeling fine, to on the ground. when I got back up I started to go again, and the "fight" began lol. Unpleasant for sure but that is where my curiosity came from.


I will definitely start taking my BP after I take Ativan in general. I am going through some stuff right now that's causing me to take it semi-regularly and I wonder if it is dropping my BP lower than it normally is, that would explain some things. I keep telling my doctor about my BP but they don't seem to be actually taking it in to account when they are giving me medications lol. I have recently realized (after the prazosin fiascos) that I have to specifically ask them to tell me the dangers/side effects I guess thank you again for the information and time you took to respond to me.

No problem! Thanks for asking too

 

[MatiSendiri]

Daily bump for today!