Resource Informational resources for opioids, benzos, and alcohol

[TheSource]

Since most people are against OD as a method, there isn't much information here on how to do it. Since I'm using overdose as my method, I figured I may as well cite my sources on a thread.

I'm in no way encouraging anyone else to try this. Attempting and failing CTB from overdose can lead to a plethora of physical and (worsened) mental issues. This is mostly for me so I can double-check my plan. I'm sick of getting lost in my random tabs.

I'm using oxy, xanax, and alcohol. The solids will be in pill/tablet form, everything taken orally. Some resources will focus on those specifics.

I'll keep editing as I find more of the sources I used.

Morphine Milligram Equivalence Calculator:

Morphine Milligram Equivalents (MME) Calculator

The Morphine Milligram Equivalents (MME) Calculator calculates total daily morphine milligram equivalents.

www.mdcalc.com

Oxycontin in Your System:

How Long Does Oxycontin Stay in Your Body?

Do you wonder how long Oxycontin stays in your system? Read this post to learn what oxycodone does to the body, how long it stays there, and what the signs of Oxycontin addiction are.

www.addictiongroup.org

A scientific article on Oxycodone-Related Deaths:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917044/

A scientific article on how ethanol reverses the tolerance to oxycodone and hydrocodone:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454589/

Benzo Equivalence Table:

benzo.org.uk : Benzodiazepine Equivalence Table

benzo.org.uk - Benzodiazepine Equivalence Table

www.benzo.org.uk

Drug Minimum Lethal Doses (not fully reliable):

Drug MLDs - Lost All Hope

The tables listing the drugs used in drug poisoning deaths show that it is possible to use drugs as a successful method of suicide using a variety of different drugs. One important success factor is the dosage – how much of any particular drug needs to be taken for it to be lethal. Minimum...

lostallhope.com

Abstract on grapefruit juice and oral oxycodone:

Grapefruit juice enhances the exposure to oral oxycodone - PubMed

Grapefruit juice alters the concentrations of many CYP3A substrates. The objective of this study was to examine the effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of oral oxycodone in a randomized cross-over study with two phases at an interval of 4 weeks. Twelve healthy...

pubmed.ncbi.nlm.nih.gov

Abstract on how alcohol increases concentrations of xanax:

Influence of ethanol on the metabolism of alprazolam - PubMed

Ethanol might increase the toxicity of alprazolam by inhibiting the activity of CYP3A4, although other pharmacokinetic processes may be affected. Ethanol could change the conformation of CYP3A4 and affect alprazolam binding.

pubmed.ncbi.nlm.nih.gov

Mixing Benzos and Opioids:

Mixing Benzos and Opioids: What You Should Know

Mixing opioids and benzodiazepines can be a dangerous combination. Here’s what to know if you take both of these drugs.

www.webmd.com

 

[bluebus]

There should definitely be a megathread for this. Od's can be so unpredictable, painful, an ineffective, but they can also be a great method, if researched and done right (like every other method here). It'd be great if someone with a technical and thorough knowledge of this topic (like GasMonkey for the inert gas community) could come up with something like that.

 

[TheSource]

A scientific article on Oxycodone-Related Deaths:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917044/

Conversion of micrograms per gram to grams per kilogram:

Convert microgram/gram to gram/kilogram - Conversion of Measurement Units

Do a quick conversion: 1 micrograms/gram = 0.001 gram/kilogram using the online calculator for metric conversions. Check the chart for more details.

www.convertunits.com

A scientific article on opioid deaths including benzodiazepines:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8288032/

Article on the strength of Morphine vs. Oxycodone:

Morphine Vs Oxycodone | Which is more Dangerous?

Both morphine and oxycodone are narcotic painkillers and belong to the opioid category. Hence, they share the same mechanism of action in order to manage pain.

balanceluxuryrehab.com

Article on the effects of Pepto Bismol with alcohol:

What Can Happen If You Combine Pepto-Bismol and Alcohol?

Here are some basic on the effects of Pepto-Bismol and alcohol — separately and in combination.

www.healthline.com

Oxycodone vs. OxyContin (immediate release vs. extended release):

Oxycodone vs. OxyContin: What Is the Difference?

OxyContin is the extended-release form of oxycodone. We’ll help you compare how these drugs treat pain, what their side effects are, and more.

www.healthline.com

 

[TheSource]

Abstract on risk of OD in long-acting vs. short-acting opioids:

Prescription opioid duration of action and the risk of unintentional overdose among patients receiving opioid therapy - PubMed

To our knowledge, the findings of the present study provide the first evidence that the risk of unintentional overdose injury is related to the prescribed opioid's duration of action. If replicated in other cohorts, our findings suggest that clinicians weighing the benefits and risks of...

pubmed.ncbi.nlm.nih.gov

How Long Does Xanax Last?:

How Long Does Xanax Last: Withdrawal, in Your System, and More

People taking Xanax often build up a tolerance. It may take longer to feel the effects of Xanax or it may not feel as strong. Here's what you need to know.

www.healthline.com

Blood-Alcohol Concentration Calculator:

BAC Calculator

Online calculator to estimate the Blood Alcohol Concentration (BAC) level based on the amount of alcohol consumed, the time elapsed, gender, and body weight.

www.calculator.net

How Long Does Oxycodone Stay In Your System?:

How Long Does Oxycodone Stay in Your System: Blood and More

Oxycodone is an opioid drug used to relieve moderate to severe pain in adults who can’t be treated with other pain medications.

www.healthline.com

Xanax on an Empty Stomach:

https://wholesomealive.com/taking-xanax-on-an-empty-stomach/

Abstract on grapefruit and drug interactions:

Understanding the grapefruit-drug interaction - PubMed

The inhibitory interaction of grapefruit juice and CYP3A4 medication metabolism was discovered in 1989. CYP3A4 enzymes are responsible for the metabolism of more than 60% of orally-administered drugs. Grapefruit components inhibit CYP3A4 drug oxidation and P-glycoprotein transportation, allowing...

pubmed.ncbi.nlm.nih.gov

 

[randal_bond]

I research the same thing. Does anyone know if Thiopental orally can be used for OD? I don't think there's enough time to inject it IV as a bolus, plus painful, so speed can't be controlled.

I research the same thing. Does anyone know if Thiopental orally can be used for OD? I don't think there's enough time to inject it IV as a bolus, plus painful, so speed can't be controlled.

Can you share what will be your personal regime?

 

[TheSource]

Can you share what will be your personal regime?

Here's the link to my other thread where I talk about it.

Oxy Polysubstance CTB? (Oxycodone + Xanax + Alcohol + Grapefruit Juice + Maybe Tylenol)

The only method available to me is OD and these are the only drugs available to me. Please don't point me toward another method, just reliable doses. I'm 145 lbs (66 kgs), about 22% body fat, and a female. No tolerance for anything. I was thinking about just taking a bunch of downers...

sanctioned-suicide.net

I'll probably update again as I get closer to my CTB date, or just post my final plan on my goodbye thread.

 

[randal_bond]

Other barbiturates

Nitschke and Stewart3​ claim that10g of Phenobarb (250 of the 30mg tablets) and Pentothal (thiopentone sodium) (10gm/20 ampules dissolved in 50ml of water) are also both lethal, and potentially easier to obtain than Nembutal.

Thiopental - 10gm/20 ampules? So, 10g orally will do it?

 

[TheSource]

Abstract on risk of OD in long-acting vs. short-acting opioids:

Found the full scientific article:

Opioid Duration of Action and Risk of Overdose

This propensity score–adjusted cohort study finds that the risk of unintentional opioid overdose injury is related to the prescribed opioid’s duration of action. Accompanying editorial by Katz.

jamanetwork.com

 

[deepblack]

OD in long-acting vs. short-acting opioids

Since you're apparently dealing a lot with those kinds of topics, is there a summary or "rule of thumb" on how short-acting/long-acting will affect chances to succeed in terms of CTB? Or does it depend on what/if other substances are used, what's the general correlation?
Also, do you know any resources/infos about short-/long-acting of research chemical opioids, especially nitazenes which are said to be far stronger than i.e. fentanyl. Can't really find infos if those are short or long acting though.

Thanks for your efforts, btw.

 

[TheSource]

Since you're apparently dealing a lot with those kinds of topics, is there a summary or "rule of thumb" on how short-acting/long-acting will affect chances to succeed in terms of CTB? Or does it depend on what/if other substances are used, what's the general correlation?
Also, do you know any resources/infos about short-/long-acting of research chemical opioids, especially nitazenes which are said to be far stronger than i.e. fentanyl. Can't really find infos if those are short or long acting though.

Thanks for your efforts, btw.

I'm actually in the middle of reading an article about short vs. long acting opioids right now. It's extremely hard to find studies on it, as most researchers aren't really set on finding out the correlation between lethality and duration. I'm not sure why that is. I'll add the article to the thread if I see anything that could be of use.
@deepblack I'm gonna make a new thread that specifically focuses on IR and ER. It seems like a wide misconception that IR is more dangerous. I don't have much info yet, but hopefully more people can look into it and add onto the findings.

 

[TheSource]

My new resource thread specifically for ER vs. IR:

ER Opioids Are More Lethal Than IR

It seems to be a huge misconception that immediate-release (short-acting) opioids are more lethal than extended-release (long-acting/controlled-release). Though they are more likely to be abused, that's because there is more satisfaction from the immediate high. Comparing the lethality, though...

sanctioned-suicide.net

 

[TheSource]

What to Know About Antiemetics for Nausea:

What to Know About Antiemetics for Nausea

Find out what you need to know about antiemetics. Discover the pros, cons, risks, and benefits, and. how taking them may affect your health.

www.webmd.com

Antiemetic drugs: what to prescribe and when:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186277/

Opioids and Nausea:

https://www.mypcnow.org/fast-fact/opioids-and-nausea/

Nausea and Vomiting Side Effects with Opioid Analgesics during Treatment of Chronic Pain: Mechanisms, Implications, and Management Options:

Nausea and Vomiting Side Effects with Opioid Analgesics during Treatment of Chronic Pain: Mechanisms, Implications, and Management Options

Abstract. Objectives. Gastrointestinal (GI) side effects such as nausea and vomiting are common following opioid analgesia and represent a significant cause of

academic.oup.com

 

[TheSource]

Opioid-induced nausea and vomiting:

Opioid-induced nausea and vomiting - Smith - Annals of Palliative Medicine

Preventing opioid-induced nausea and vomiting: Rest your head and close your eyes?:

Preventing opioid-induced nausea and vomiting: Rest your head and close your eyes?

Although opioid-induced nausea and vomiting (OINV) is common and debilitating, its mechanism is still unclear. Recently, we suggested that opioids affect semicircular canal function and that this leads to a mismatch between canal input and other sensory information during head motion, which...

journals.plos.org

Abstract ~ The effects of food on opioid-induced nausea and vomiting and pharmacological parameters: a systematic review:

The effects of food on opioid-induced nausea and vomiting and pharmacological parameters: a systematic review - PubMed

Opioids remain the standard of care for treating moderate to severe pain resulting from surgery or injury in cases of acute pain, and are recommended for patients who have not responded to nonopioid analgesics. Effective management of pain has an impact on clinical course and often depends on...

pubmed.ncbi.nlm.nih.gov

What happens when you drink alcohol:

What happens when you drink alcohol

When you drink alcohol, you don’t digest alcohol. It passes quickly into your bloodstream and travels to every part of your body. Alcohol affects your brain first, then your kidneys, lungs and liver. The effect on your body depends on your age, gender, weight and the type of alcohol.

www.nidirect.gov.uk

Citric acid reduces the decline in P300 amplitude induced by acute alcohol consumption in healthy adults:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348231/#sec-a.k.ctitle