Sigh, this shit again. P-glycoprotein inhibition as a miraculous means to make loperamide cross the blood brain barrier isn't new, has been discussed for 20+ years on the drug sites, and if it worked to any appreciable degree, loperamide would be scheduled like diphenoxylate. It doesn't. Loperamide at the very best produces exceptionally mild (and I do mean exceptionally) CNS effects, is an incredibly poor substitute for proper opioids, and can only alleviate some of the peripheral withdrawal symptoms in addicts.
Loperamide can be fatal in high doses in some cases, but this has nothing to do with the central opioid effects. I'll summarize as follows - you can take a massive amount of quinine and a massive amount of loperamide. While the combination may prove fatal, this will be due to the cardiac effects of both, has nothing to do with the cns opioid effects, will not be peaceful, and it will taste like shit.
Loperamide can be fatal in high doses in some cases, but this has nothing to do with the central opioid effects. I'll summarize as follows - you can take a massive amount of quinine and a massive amount of loperamide. While the combination may prove fatal, this will be due to the cardiac effects of both, has nothing to do with the cns opioid effects, will not be peaceful, and it will taste like shit.
