Deleted member 24006
- Nov 20, 2020
Nembutal - 26.7 g of clean metallic sodium are dissolved in 400 g of anhydrous (dry) ethanol. To this, a solution of 100 g of 1-methyl butyl-ethyl malonic ester and 37.2 g of dry urea is added. The mixture is heated for 4 to 6 hours in an autoclave. The alcohol is then removed by distillation. The residue is dissolved in water and this aqueous solution is acidified with hydrochloric acid. The precipitated product is filtered, washed with cold water, and recrystallized from boiling water. Yield: depends on your ability to exclude H2O from the beginning of the reaction.