Method Proposing a new, easily-accessible method - Propofol (A Theoretical Method of Dying - The Two Drug Combination - Emulating BC's MAiD Protocol)

[Sunset Limited]

what will happen first, embolism or loss of consciousness from anestofol? I wouldn't want to experience embolism. The instructions say loss of consciousness within 30-60 seconds
Somehow this anestofol doesn't inspire confidence, there were several reviews on the website where it is sold that it doesn't work. Maybe the storage conditions were violated

As i said propofol is a hydrophobic phenol and is not soluble in water but is soluble in oil. Medical use propofol is an oil emulsion. From what i have seen Anestofol is just oil. They seem to have dissolved the propofol and lidocaine in the oil. If that is the case you are right to be concerned about it being unreliable.

If Anestofol works you will be unconscious long before the oil embolism symptoms. The procedure should have been an injection of propofol followed by an injection of lidocaine. I do not know if there are any published scientific studies on anestofol. I suggest you do some research.

 

[DeadManLiving]

can you send me the reviews? thats strange. i mean ppl put down their animals with it and might have done it incorrectly. since they are not vets. its possible i guess

On par, although I think the convention now is infusion of pure potassium as the primary mechanism of (lethal) action, sedatives like Profanol are only anesthetic deterrents to mitigate distress before the initiation of the veterinary protocol.

 

[sevennn]

why would it be unreliable? im getting more and more confused about this method

 

[supremacyofdeath]

commenting to come back later to this.

 

[sevennn]

can anyone just tell me if anestofol would work or not. i have bottles of this stuff.

 

[Sunset Limited]

can anyone just tell me if anestofol would work or not. i have bottles of this stuff.

"Somehow this anestofol doesn't inspire confidence, there were several reviews on the website where it is sold that it doesn't work."

This is an important statement. When I saw anestofol on this site, the first question I asked myself was "how do you combine propofol with lidocaine?" If you emulsify propofol, the emulsion breaks when you add lidocaine. How did they combine them since they can't inject oil into the system? I see now that I overestimated the Russians. Anestofol is probably not a well-studied drug. It is just an oil solution. Injecting oil into the bloodstream causes problems other than oil embolism.

But still, the statement I quoted is clearly the most important thing that makes Anestofol unreliable. IndiaMart sells medical use propofol. Especially the 2% form is the best option. Since it requires 2 or more infusion pumps or a gravity-fed infusion pump like mine, powered by 3 x 60cc syringes, it makes the method quite complicated.

 

[Gone.]

As i said propofol is a hydrophobic phenol and is not soluble in water but is soluble in oil. Medical use propofol is an oil emulsion. From what i have seen Anestofol is just oil. They seem to have dissolved the propofol and lidocaine in the oil. If that is the case you are right to be concerned about it being unreliable.

If Anestofol works you will be unconscious long before the oil embolism symptoms. The procedure should have been an injection of propofol followed by an injection of lidocaine. I do not know if there are any published scientific studies on anestofol. I suggest you do some research.

There will not be specific research on a specific brand and manufacturer of a generic drug. Also, if it causes oil embolism how would they use it in medically assisted dying and in general anesthesia?

On par, although I think the convention now is infusion of pure potassium as the primary mechanism of (lethal) action, sedatives like Profanol are only anesthetic deterrents to mitigate distress before the initiation of the veterinary protocol.

Pure potassium is a metal- Good luck infusing that.

"Somehow this anestofol doesn't inspire confidence, there were several reviews on the website where it is sold that it doesn't work."

This is an important statement. When I saw anestofol on this site, the first question I asked myself was "how do you combine propofol with lidocaine?" If you emulsify propofol, the emulsion breaks when you add lidocaine. How did they combine them since they can't inject oil into the system? I see now that I overestimated the Russians. Anestofol is probably not a well-studied drug. It is just an oil solution. Injecting oil into the bloodstream causes problems other than oil embolism.

But still, the statement I quoted is clearly the most important thing that makes Anestofol unreliable. IndiaMart sells medical use propofol. Especially the 2% form is the best option. Since it requires 2 or more infusion pumps or a gravity-fed infusion pump like mine, powered by 3 x 60cc syringes, it makes the method quite complicated.

As far as I am aware, the fat bubbles shouldn't pose that big of an issue. The reliability is the same as the drug is still entering your body in the same route.

 

[Sunset Limited]

As far as I am aware, the fat bubbles shouldn't pose that big of an issue. The reliability is the same as the drug is still entering your body in the same route.

Real problem is in the quote. Users said "anestofol doesn't work".
Get your own risk it is not my responsibility.

My situation is I have already reliable and approved version of propofol that medical use and still I can buy thiopental. So if I have better options why I have to inject a suspicious Russian product "oil solution" into my bloodstream? Anestofol is a shitty option for me now. Also Indiamart is selling medical use propofol and thiopental for everyone. There is no any reason to use unreliable version of propofol. Best option is thiopental from indiamart for IV route now.

 

[sevennn]

but how do we know that these people that left reviews have been using it correctly. they are not even vets. just random buyers trying to put their animals down (ive seen really dumb questions from buyers about the product on these sites). who knows they mightve injected it into the muscle or some thing. its not easy to poke an animal into a vein or am i being stupid guys. idk. im looking into the gas method now

 

[Sunset Limited]

but how do we know that these people that left reviews have been using it correctly. they are not even vets. just random buyers trying to put their animals down (ive seen really dumb questions from buyers about the product on these sites). who knows they mightve injected it into the muscle or some thing. its not easy to poke an animal into a vein or am i being stupid guys. idk. im looking into the gas method now

I am sorry but no one can be stupid as try to do their pet's euthanasia. They are not only a pet for them, they like friends. Why would someone want to buy drugs online and use them without authorization? I have never heard of anyone trying to do this. Sounds like bs.

You can buy thiopental from indiamart you don't have to use Anestofdl. Also thiopental is better option for IV route. This way you won't have to answer unnecessary questions about anestofol.

 

[sevennn]

I am sorry but no one can be stupid as try to do their pet's euthanasia. They are not only a pet for them, they like friends. Why would someone want to buy drugs online and use them without authorization? I have never heard of anyone trying to do this. Sounds like bs.

You can buy thiopental from indiamart you don't have to use Anestofdl. Also thiopental is better option for IV route. This way you won't have to answer unnecessary questions about anestofol.

what do you mean no one. thats what regular people buy it for. all the reviews are about that. why? because pets get old and sick. im just telling you what i read while i was buying it. what reviews did you think that guy was talking about

 

[Sunset Limited]

what do you mean no one. thats what regular people buy it for. all the reviews are about that. why? because pets get old and sick. im just telling you what i read while i was buying it. what reviews did you think that guy was talking about

Regular ppl? Regular ppl don't manage euthanasia of their pets. Only stupid ppl try it. How do you know they are "regular ppl"? Probably they are veterinarians. Still as I said there is a better option there thiopental from indiamart but if do you want to inject an oil solution to yourself no one will stop you.

 

[sevennn]

Regular ppl? Regular ppl don't manage euthanasia of their pets. Only stupid ppl try it. How do you know they are "regular ppl"? Probably they are veterinarians. Still as I said there is a better option there thiopental from indiamart but if do you want to inject an oil solution to yourself no one will stop you.

literally just look it up on ru sites and you will see they are regular people. it is obvious. they are not veterinarians 100%. yeah.. anyway im researching about the gas method now. i dont want to order anything from indiamart or whatever

 

[Sunset Limited]

literally just look it up on ru sites and you will see they are regular people. it is obvious. they are not veterinarians 100%. yeah.. anyway im researching about the gas method now. i dont want to order anything from indiamart or whatever

Can you give me a link to comments I want to see. Still it is ridiculous who try to manage their pet's euthanasia. Stupidity must have borders.

 

[sevennn]

Can you give me a link to comments I want to see. Still it is ridiculous who try to manage their pet's euthanasia. Stupidity must have borders.

i dont want to "link sources" or something i dotn think its allowed. can you allow me to send you a message?

 

[Sunset Limited]

i dont want to "link sources" or something i dotn think its allowed. can you allow me to send you a message?

Sure you can send now thanks.

 

[anonymousperson]

Has anyone successfully used this method?

 

[RadiantNumber]

What you need:
1000mg of propofol - You can get this from Russian clearnet pharmacies. It is marketed for the euthanasia for animals. Propofol is generally not a controlled substance, and is widely used for the induction of anesthesia.

It is as easy to get this?

 

[sevennn]

Has anyone successfully used this method?

there are some cases of people using propofol. you can look them up.

 

[sevennn]

chatgpt is calling this a micellar solution. not an oil. if anyone wants i can post what it said. dont know how much i can trust tho, but it seems to be correct. there is an emulsifying agent in it - macrogol 15

 

[brokenspirited]

Is procuring and possessing these substances illegal? Also what is the shelf life of the ingredients? Do these Russian pharmacies ship to North America?

 

[sevennn]

Is procuring and possessing these substances illegal? Also what is the shelf life of the ingredients? Do these Russian pharmacies ship to North America?

about 3 years. the ones i bought expire in 2026 so i feel rushed if i end up using it

 

[Лена]

If you buy propofol from Russian clearnet pharmacies, you don't need other drugs because it is Anestofol. 5% lidocaine, 5% propofol. That means 20 cc of Anestofol contains 1000 mg propofol + 1000 mg lidocaine. Perfect combined!

Since it contains lidocaine, there is no injection pain. A bolus dose that 20 - 25 cc of Anestofol is enough to guaranteed painless CTB for everyone. Although this dose does not inhibit respiration long enough to cause asphyxia, profound hypotension and cardiovascular collapse are there.

If we are talking about IV route, Anestofol is better than N. Great job from Russians.

Anyone bought Anestofol from clearnet pharmacies? I want to put it to my CTB bag.

Где вы видели, чтобы пропофол в России продавали без рецепта?

 

[sevennn]

Где вы видели, чтобы пропофол в России продавали без рецепта?

you need to reread carefully

 

[unluckysadness]

Just wanted to boost this thread. Why is propofol not more discussed ? I've found a link on russian clearnet but I think it's a scam

 

[Dusk till dawn]

Just wanted to boost this thread. Why is propofol not more discussed ? I've found a link on russian clearnet but I think it's a scam

It's effect lasts for 5-10 minutes, normal IV injections are unlikely to work no matter what to summarise everything i'm about to yap about

Michael jackson accidentally died of a propofol overdose but he was connected to a IV infusion device, most people here don't know how to use needles and set up cannulas and IV infusion devices, creating a setup for this method is very difficult and convoluted and technical, people rarely study pharmacology and pharmacokinetics, that's why these methods are rarely brought up, and if you could get propofol OTC like that and you have the skills to set it up and configure a IV infusion device to pump stuff at a good pace to sustain CNS depression until apnea and respitatory arrest occurs you'd probably be able to find other GABA-A agonists with better duration of action

It just won't work with a syringe or a needle, it can't contain 1000mg of propofol in one syringe or needle and even if it does you'll never inject it in time before falling unconscious, the concentations are usually 10mg propofol per 1 milileter (1000mg propofol = 100 ml)

It's not impossible to circumvent this if you know how to synthesize propofol and emulsify and sterilize it (synthesized propofol is highly lipid, needs to be emulsified otherwise you're trying to inject a rock into your vein, it won't work otherwise), if you can do this then you could get a molecule with your own rules, like 10ml/1 gram, theorically, you can inject it all before losing consciousness if you do it perfectly or practise beforehand, but so long as propofol's duration of action is 5-10 minutes, there are still a few hurdles you have to pass now that you've pulled off the impossible and injected 1 gram of propofol intravenously before losing consciousness

If it goes perfectly in this scenario (a simple and quick needle injection) and you immediately go into deep CNS depression to the extent apnea happens almost immediately, and the molecule holds up for 10 minutes, then keep in mind permanent brain damage starts only after 4 minutes without oxygen and death can occur as soon as 4 to 6 minutes later if apnea is consistent, you can end up vegetative if it fails, and brain damage will always happen in this scenario should propofol's duration of action betray you

This method is unpractical for normal people, high skill in execution and very complex in proper set-ups that can work, i don't think anyone other than healthcare professionals who know how to hit a good, set up a cannula and a IV infusion device properly, could really pull it off in real life, and even if they could they'd be smart enough to realise how difficult it is to pull off and know the risks of trusting your fate to a short duration of action drug if your setup was flawed

 

[David753]

Можете прислать мне отзывы? Это странно. Я имею в виду, что люди усыпляют своих животных этим средством и могли сделать это неправильно. Поскольку они не ветеринары. Возможно, я так думаю.

Его продавали на торговой площадке Ozon. Сейчас, я вижу, его там больше нет. Среди сотен отзывов было два-три, где говорилось, что он не работает. Не знаю, может, его неправильно использовали.

Как я уже говорил, пропофол — гидрофобный фенол, нерастворимый в воде, но растворимый в масле. Медицинский пропофол представляет собой масляную эмульсию. Насколько я знаю, анестофол — это просто масло. Похоже, что пропофол и лидокаин растворили в масле. Если это так, то вы правы, беспокоясь о его ненадёжности.

Если анестофол сработает, вы потеряете сознание задолго до появления симптомов масляной эмболии. Процедура должна была включать инъекцию пропофола, а затем лидокаина. Не знаю, есть ли опубликованные научные исследования по анестофолу. Советую вам изучить вопрос.

I'll look for 2% propofol

 

[Sunset Limited]

It's effect lasts for 5-10 minutes, normal IV injections are unlikely to work no matter what to summarise everything i'm about to yap about

Michael jackson accidentally died of a propofol overdose but he was connected to a IV infusion device, most people here don't know how to use needles and set up cannulas and IV infusion devices, creating a setup for this method is very difficult and convoluted and technical, people rarely study pharmacology and pharmacokinetics, that's why these methods are rarely brought up, and if you could get propofol OTC like that and you have the skills to set it up and configure a IV infusion device to pump stuff at a good pace to sustain CNS depression until apnea and respitatory arrest occurs you'd probably be able to find other GABA-A agonists with better duration of action

It just won't work with a syringe or a needle, it can't contain 1000mg of propofol in one syringe or needle and even if it does you'll never inject it in time before falling unconscious, the concentations are usually 10mg propofol per 1 milileter (1000mg propofol = 100 ml)

It's not impossible to circumvent this if you know how to synthesize propofol and emulsify and sterilize it (synthesized propofol is highly lipid, needs to be emulsified otherwise you're trying to inject a rock into your vein, it won't work otherwise), if you can do this then you could get a molecule with your own rules, like 10ml/1 gram, theorically, you can inject it all before losing consciousness if you do it perfectly or practise beforehand, but so long as propofol's duration of action is 5-10 minutes, there are still a few hurdles you have to pass now that you've pulled off the impossible and injected 1 gram of propofol intravenously before losing consciousness

If it goes perfectly in this scenario (a simple and quick needle injection) and you immediately go into deep CNS depression to the extent apnea happens almost immediately, and the molecule holds up for 10 minutes, then keep in mind permanent brain damage starts only after 4 minutes without oxygen and death can occur as soon as 4 to 6 minutes later if apnea is consistent, you can end up vegetative if it fails, and brain damage will always happen in this scenario should propofol's duration of action betray you

This method is unpractical for normal people, high skill in execution and very complex in proper set-ups that can work, i don't think anyone other than healthcare professionals who know how to hit a good, set up a cannula and a IV infusion device properly, could really pull it off in real life, and even if they could they'd be smart enough to realise how difficult it is to pull off and know the risks of trusting your fate to a short duration of action drug if your setup was flawed

I think you didn't read the thread completely. What this thread mentions isn't 1% propofol for medical use. It's Anestofol. It's propofol for euthanasia, of Russian origin. It comes in vials as 10cc Anestofol = 5% Propofol + 5% Lidocaine. So, 10cc Anestofol contains 500mg propofol + 500mg lidocaine. The onset of action of propofol is 15 seconds from the moment you start pushing the plunger. With a 22g cannula, you can inject 25-30ccs into a large vein in the arm in 15 seconds. That means 1500mg propofol + 1500mg lidocaine for 30cc Anestofol. Actually, even 20cc is enough.

I'm leaving below the graph generated by the "stan pump" pharmacokinetic simulation model to see what happens if a 30-year-old, 70kg, healthy, non-addicted man takes 1000mg propofol and standart induction dose. In this scenario, respiratory arrest wouldn't be the cause of death. Propofol's sympatholytic effect leads to vasodilation ---> profound hypotension ---> cardiovascular collapse. Of course, sympatholytic effects aren't the only factor in the equation. Propofol causes myocardial depression at high doses, reducing cardiac output. While this alone is enough, if we also factor in the negative inotropic effects of 1000mg lidocaine, the only way someone could survive in this scenario is if they are coming from the planet Krypton and the letter "S." Due to a misunderstanding at the hospital, the patient was given 300mg of propofol instead of 150mg. Despite immediate intubation and inotriopic support through two IV cannulas, he could not be resuscitated. This is because there is no reversal agent for propofol. Even the standard induction dose is always injected slowly to maintain hemodynamic stability.The other factor in the equation, of course, is airway collapse.






"If it goes perfectly in this scenario (a simple and quick needle injection) and you immediately go into deep CNS depression to the extent apnea happens almost immediately, and the molecule holds up for 10 minutes"

This is completely about dose. For a 70-kg person, the average dose is 2.5 mg/kg (without premedication). The target plasma concentration is 6 mcg/ml. At this concentration, awakening is expected within 10 minutes. If the dose reaches an absurd peak of 60 mcg/ml, as described above, awakening will take much longer, but of course, the person will not wake up.

Still there is a problem. Propofol injections are painful. While phenol injections are painful, the real source of pain is the oil. The Germans developed Propofol Lipuro to reduce propofol pain. While Anestofol contains lidocaine, this isn't a solution because lidocaine requires time to work. The injection is still painful. A solution could be to inject lidocaine before Anestofol, but even this doesn't completely solve the problem. This is the main problem with Anestofol. There's a better way to numb a vein, but it's too difficult for someone who isn't a healthcare professional.

"This method is unpractical for normal people, high skill in execution and very complex in proper set-ups that can work, i don't think anyone other than healthcare professionals who know how to hit a good, set up a cannula and a IV infusion device properly, could really pull it off in real life, and even if they could they'd be smart enough to realise how difficult it is to pull off and know the risks of trusting your fate to a short duration of action drug if your setup was flawed"

I agree with this. Catheterization, drip infusion setup, and management of an infusion pump are unrealistic for a non-healthcare professional. Catheterization is enough for the 20cc anestofol bolus method. For the average person, learning catheterization takes 3-4 months. Maybe more.

Его продавали на торговой площадке Ozon. Сейчас, я вижу, его там больше нет. Среди сотен отзывов было два-три, где говорилось, что он не работает. Не знаю, может, его неправильно использовали.

I'll look for 2% propofol

In my opinion, thiopental is currently the best option for IV use from "IM" (source). The injection is less painful than propofol, and since it comes in powder form, dosing is easy.

 

[G50]

Catheterization, drip infusion setup, and management of an infusion pump are unrealistic for a non-healthcare professional.

Homemade Infusion Pump Method for Injecting 5% Anestofol

I've been experimenting with a 35 ml syringe to which I have attached some elastic material (waistband elastic, 1 inch wide) which automatically pushes the syringe plunger down. With this setup, I believe I may be able to inject 30 ml of 5% Anestofol over a period of about 2 minutes (I have timed it, and it takes nearly 2 minutes to pass 30 ml).

Consciousness will be lost after around 15 seconds, but the waistband elastic will continue to inject the Anestofol. So this setup acts as a very cheap and simple infusion pump.

I connect the syringe to an infusion set about which has a 23 gauge needle (inner diameter 0.3 mm). The tube on this infusion set is about 30 cm in length (I use a TERUMO SURFLO winged infusion set).

Because the 23 gauge needle is narrow, it restricts the flow of the Anestofol. In my tests using 30 ml of water in the syringe, the waistband elastic pushed the water through the infusion set and needle at the following rates:

• 1st 10 ml of water took 26 seconds to pass, so flow rate is 10 / 26 = 0.38 ml per second.
• 2nd 10 ml of water took 33 seconds to pass, so flow rate is 10 / 33 = 0.3 ml per second.
• 3rd 10 ml of water took 46 seconds to pass, so flow rate is 10 / 46 = 0.22 ml per second.

Total time = 105 seconds = 1.75 minutes.

When the needle is inserted into a vein, the flow rate will be a little slower, as it will be working against blood pressure. But blood pressure will be quite low if you are lying down horizontally (venous blood pressure when lying horizontally is about 7 mmHg = around 10 cm of water).

In a second test with needle placed under the pressure of a 45 cm height of water, so as to simulate venous blood pressure, the following flow rates were achieved:

• 1st 10 ml of water took 33 seconds to pass, so flow rate is 10 / 33 = 0.3 ml per second.
• 2nd 10 ml of water — error in experiment, no data.
• 3rd 10 ml of water took 130 seconds to pass, so flow rate is 10 / 130 = 0.077 ml per second.

———————————————————————————————————————————————


I am just wondering if upper airway obstruction when under the anaesthetic propofol might be an issue. Or will you have already lost consciousness before this happens?

According to AI:

Propofol results in a loss of pharyngeal muscle tone.

Propofol strongly suppresses:

• Genioglossus (the genioglossus is the primary muscle preventing tongue fallback)
• Pharyngeal dilator muscles
• Soft palate tension

When these relax:

• The tongue falls backward toward the posterior pharyngeal wall.
• The oropharynx narrows or closes.
• The soft palate may block the nasopharynx.

 

[Sunset Limited]

Homemade Infusion Pump Method for Injecting 5% Anestofol

I've been experimenting with a 35 ml syringe to which I have attached some elastic material (waistband elastic, 1 inch wide) which automatically pushes the syringe plunger down. With this setup, I believe I may be able to inject 30 ml of 5% Anestofol over a period of about 2 minutes (I have timed it, and it takes nearly 2 minutes to pass 30 ml).

Consciousness will be lost after around 15 seconds, but the waistband elastic will continue to inject the Anestofol. So this setup acts as a very cheap and simple infusion pump.

I connect the syringe to an infusion set about which has a 23 gauge needle (inner diameter 0.3 mm). The tube on this infusion set is about 30 cm in length (I use a TERUMO SURFLO winged infusion set).

Because the 23 gauge needle is narrow, it restricts the flow of the Anestofol. In my tests using 30 ml of water in the syringe, the waistband elastic pushed the water through the infusion set and needle at the following rates:

• 1st 10 ml of water took 26 seconds to pass, so flow rate is 10 / 26 = 0.38 ml per second.
• 2nd 10 ml of water took 33 seconds to pass, so flow rate is 10 / 33 = 0.3 ml per second.
• 3rd 10 ml of water took 46 seconds to pass, so flow rate is 10 / 46 = 0.22 ml per second.

Total time = 105 seconds = 1.75 minutes.

When the needle is inserted into a vein, the flow rate will be a little slower, as it will be working against blood pressure. But blood pressure will be quite low if you are lying down horizontally (venous blood pressure when lying horizontally is about 7 mmHg = around 10 cm of water).

In a second test with needle placed under the pressure of a 45 cm height of water, so as to simulate venous blood pressure, the following flow rates were achieved:

• 1st 10 ml of water took 33 seconds to pass, so flow rate is 10 / 33 = 0.3 ml per second.
• 2nd 10 ml of water — error in experiment, no data.
• 3rd 10 ml of water took 130 seconds to pass, so flow rate is 10 / 130 = 0.077 ml per second.

———————————————————————————————————————————————


I am just wondering if upper airway obstruction when under the anaesthetic propofol might be an issue. Or will you have already lost consciousness before this happens?

According to AI:

Propofol results in a loss of pharyngeal muscle tone.

Propofol strongly suppresses:

• Genioglossus (the genioglossus is the primary muscle preventing tongue fallback)
• Pharyngeal dilator muscles
• Soft palate tension

When these relax:

• The tongue falls backward toward the posterior pharyngeal wall.
• The oropharynx narrows or closes.
• The soft palate may block the nasopharynx.

I tried using elastic material and syringes. It's not a bad idea. If I didn't have my own injection system, I would definitely use it. However, keep in mind that with a cannula inserted into a vein, a true flow test isn't possible. I've done this many times with my system, as it's also a skill repetition. With the elastic material and syringe method, you can hang the syringe higher and utilize gravity feed. This increases the injection speed.

If you inject yourself with 30cc of anestofol in a short time, this will result in cardiovascular collapse before airway collapse. I've detailed this above. My advice is to practice cannulation and flow testing extensively.

Also, calculate the amount of anestofol that will remain in the infusion set. 30cm equals approximately 3cc. This is a negligible amount. Another point is the most significant problem with anestofol injection: injection pain. I've also detailed this above. This can be a major problem. It's a hellish burn that lasts 15-20 seconds. Injecting lidocaine to anesthetize the vein beforehand may reduce pain but probably not eliminate it completely.

I've included the pharmacokinetic simulation results below for a 30cc Anestofol bolus injection for a healthy 70 kg, 30-year-old man. The overall average airway collapse for patients with known obstructive sleep apnea is around 5 mcg/ml. Of course, fentanyl is also isthere in the equation. If we remove it, we can assume it's 7 mcg/ml. While some patients can protect their airway with doses up to 12 mcg/ml, these are extreme cases. For healthy individuals, airway collapse with propofol alone is around 10 mcg/ml.

The yellow line I drew represents the depth of surgical anesthesia, and the red line represents the limit at which a healthy person cannot protect their airway. However, as I mentioned, cardiovascular collapse is there before airway collapse.