Starting a general thread about using the drug, information is scattered as of yet,. For as far as I know.
I guess it would be a little chaotic.
https://www.caymanchem.com/msdss/20965m.pdf
Human oral LD50 36 mg/kg, oral LD50 rat 125 mg/kg, oral LD50 mouse 170 mg/kg
https://en.wikibooks.org/wiki/Suicide/Toxification/Pentobarbital
'
Tolerance and withdrawal[edit]
The prolonged use of barbiturates leads to tolerance. Also, cross-tolerance between barbiturates and benzodiazepines can be presented, since both drugs act through the GABA receptors. Hence, it is suggested that a period of 3–4 weeks of withdrawal can reverse the tolerance and this process is indeed needed for having one's attempt be a reliable one. As with all intoxication procedures, it is recommended that all consumption of medications that do not affect judgement be stopped some time in advance to drug ingestion, as well as consumption of alcohol and narcotics. Anti-psychotics have been mentioned as one confounding factor in failed or prolonged attempts, according to The Peaceful Pill Handbook. '
'However, experts in human anaesthesia have pointed out that pentobarbital, while an anaesthetic, is not a full analgesic. As such, coadministration of an appropriate analgesic may be advisable to completely eliminate risk of perceived pain, although reports of adverse events have been sparse. Suggestions for analgesics seem unclear at this time, perhaps a low-moderate dose opioid could be an option. The US Death with Dignity homepage mentions a mix of phenobarbital, choral hydrate, morphine sulfate and ethanol as a less expensive option to secobarbital. These additions are possibly due to phenobarbital being slower acting. In veterinary euthanasia, a two step approach is favoured, whereby a sedative such as propofol is given prior to an IV pentobarbital dose. Oral administration is recommended only as a fallback. This method may differ slightly in effect from oral human consumption in that death occurs almost immediately, and perhaps by cardiac effects rather than respiratory depression. In the recorded events of adverse events where IV pentobarbital was used for capital punishment, the likely cause was contaminated pentobarbital from a compounding pharmacy, something which should pose a small risk when taken orally. The fact that capital punishment experts have pointed out possible weaknesses in a pentobarbital-only ingestion warrants further investigation. Reports from Dignitas, which rely on Nembutal only, are encouraging however.'
Adding an opiate ? Keep in mind that opiates may negate the effects of antiemetics.
'Some people with neurodegenerative disorders (MS, ALS) or inborn/acquired disabilities of the nervous system (autism, schizophrenia, Down's syndrome) have alterations to the functioning of the GABA system. It is not known how they respond to Nembutal, although, again, Dignitas reports are encouraging'
Soudns like fun. Either disease or caused by prescription drug. Question of effectiveness in altered CNS.
Nitschke mentions Dilantin as a means to hasten death. May be very unpleasant if still conscious ?
https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+3151
' /SIGNS AND SYMPTOMS/ In extreme overdose, all electrical activity in the brain may cease, in which case a "flat" EEG normally equated with clinical death cannot be accepted. This effect is fully reversible unless hypoxic damage occurs. Consideration should be given to the possibility of barbiturate intoxication even in situations that appear to involve trauma.'
'
/SIGNS AND SYMPTOMS/ Acute overdosage with barbiturates is manifested by CNS and respiratory depression which may progress to Cheyne-Stokes respiration, areflexia, constriction of the pupils to a slight degree (though in severe poisoning they may show paralytic dilation), oliguria, tachycardia, hypotension, lowered body temperature, and coma. Typical shock syndrome (apnea, circulatory collapse, respiratory arrest, and death) may occur.'
'
/SIGNS AND SYMPTOMS/ Overdosage of barbiturates produces CNS depression ranging from sleep to profound coma to death; respiratory depression which may progress to Cheyne-Stokes respiration, central hypoventilation, and cyanosis; cold, clammy skin and/or hypothermia or later fever, areflexia, tachycardia, hypotension, loss of peripheral vascular resistance, muscular hyperactivity (twitching to convulsive-like movements) seizures, allergic reactions, and decreased urine formation. Pupils usually are slightly constricted but may be dilated in severe poisoning. Patients with severe overdosage often experience typical shock syndrome; apnea, circulatory collapse with loss of peripheral vascular tone, cardiac arrest, respiratory arrest, and death may occur. Complications such as pneumonia, pulmonary edema, or renal failure may also prove fatal. Other complications which may occur are congestive heart failure, cardiac arrhythmias, and urinary tract infections. Some patients have bullous cutaneous lesions which heal slowly. Sweat gland necrosis may also occur. /Barbiturates General Statement/'
'Barbiturates have no analgesic action and may increase the reaction to painful stimuli at subanesthetic doses. All barbiturates exhibit anticonvulsant activity, but only phenobarbital, metharbital, and mephobarbital are effective anticonvulsants in subhypnotic doses. /Barbiturates General Statement/' Some other points as well.
Different sources, different values.
Drugs that potentiate/increase effectiveness of N ?
I'll leave it at this for now.
I guess it would be a little chaotic.
https://www.caymanchem.com/msdss/20965m.pdf
Human oral LD50 36 mg/kg, oral LD50 rat 125 mg/kg, oral LD50 mouse 170 mg/kg
https://en.wikibooks.org/wiki/Suicide/Toxification/Pentobarbital
'
Tolerance and withdrawal[edit]
The prolonged use of barbiturates leads to tolerance. Also, cross-tolerance between barbiturates and benzodiazepines can be presented, since both drugs act through the GABA receptors. Hence, it is suggested that a period of 3–4 weeks of withdrawal can reverse the tolerance and this process is indeed needed for having one's attempt be a reliable one. As with all intoxication procedures, it is recommended that all consumption of medications that do not affect judgement be stopped some time in advance to drug ingestion, as well as consumption of alcohol and narcotics. Anti-psychotics have been mentioned as one confounding factor in failed or prolonged attempts, according to The Peaceful Pill Handbook. '
'However, experts in human anaesthesia have pointed out that pentobarbital, while an anaesthetic, is not a full analgesic. As such, coadministration of an appropriate analgesic may be advisable to completely eliminate risk of perceived pain, although reports of adverse events have been sparse. Suggestions for analgesics seem unclear at this time, perhaps a low-moderate dose opioid could be an option. The US Death with Dignity homepage mentions a mix of phenobarbital, choral hydrate, morphine sulfate and ethanol as a less expensive option to secobarbital. These additions are possibly due to phenobarbital being slower acting. In veterinary euthanasia, a two step approach is favoured, whereby a sedative such as propofol is given prior to an IV pentobarbital dose. Oral administration is recommended only as a fallback. This method may differ slightly in effect from oral human consumption in that death occurs almost immediately, and perhaps by cardiac effects rather than respiratory depression. In the recorded events of adverse events where IV pentobarbital was used for capital punishment, the likely cause was contaminated pentobarbital from a compounding pharmacy, something which should pose a small risk when taken orally. The fact that capital punishment experts have pointed out possible weaknesses in a pentobarbital-only ingestion warrants further investigation. Reports from Dignitas, which rely on Nembutal only, are encouraging however.'
Adding an opiate ? Keep in mind that opiates may negate the effects of antiemetics.
'Some people with neurodegenerative disorders (MS, ALS) or inborn/acquired disabilities of the nervous system (autism, schizophrenia, Down's syndrome) have alterations to the functioning of the GABA system. It is not known how they respond to Nembutal, although, again, Dignitas reports are encouraging'
Soudns like fun. Either disease or caused by prescription drug. Question of effectiveness in altered CNS.
Nitschke mentions Dilantin as a means to hasten death. May be very unpleasant if still conscious ?
https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+3151
' /SIGNS AND SYMPTOMS/ In extreme overdose, all electrical activity in the brain may cease, in which case a "flat" EEG normally equated with clinical death cannot be accepted. This effect is fully reversible unless hypoxic damage occurs. Consideration should be given to the possibility of barbiturate intoxication even in situations that appear to involve trauma.'
'
/SIGNS AND SYMPTOMS/ Acute overdosage with barbiturates is manifested by CNS and respiratory depression which may progress to Cheyne-Stokes respiration, areflexia, constriction of the pupils to a slight degree (though in severe poisoning they may show paralytic dilation), oliguria, tachycardia, hypotension, lowered body temperature, and coma. Typical shock syndrome (apnea, circulatory collapse, respiratory arrest, and death) may occur.'
'
/SIGNS AND SYMPTOMS/ Overdosage of barbiturates produces CNS depression ranging from sleep to profound coma to death; respiratory depression which may progress to Cheyne-Stokes respiration, central hypoventilation, and cyanosis; cold, clammy skin and/or hypothermia or later fever, areflexia, tachycardia, hypotension, loss of peripheral vascular resistance, muscular hyperactivity (twitching to convulsive-like movements) seizures, allergic reactions, and decreased urine formation. Pupils usually are slightly constricted but may be dilated in severe poisoning. Patients with severe overdosage often experience typical shock syndrome; apnea, circulatory collapse with loss of peripheral vascular tone, cardiac arrest, respiratory arrest, and death may occur. Complications such as pneumonia, pulmonary edema, or renal failure may also prove fatal. Other complications which may occur are congestive heart failure, cardiac arrhythmias, and urinary tract infections. Some patients have bullous cutaneous lesions which heal slowly. Sweat gland necrosis may also occur. /Barbiturates General Statement/'
'Barbiturates have no analgesic action and may increase the reaction to painful stimuli at subanesthetic doses. All barbiturates exhibit anticonvulsant activity, but only phenobarbital, metharbital, and mephobarbital are effective anticonvulsants in subhypnotic doses. /Barbiturates General Statement/' Some other points as well.
Different sources, different values.
Drugs that potentiate/increase effectiveness of N ?
I'll leave it at this for now.
