Yes, especially the isoetazines. If you don't have a tolerance then insuffating one line will kill, most certainly in combination with benzos and absolutely in combination with alcohol.
The nausea is only something that first time users have. If you dabble with fent or opioids for a few weeks, it kind of goes away and extincts. Putting the powder in eccentric coated capsules to ensure they pass the stomach and only burst deep in the lower intestine where vomiting is not possible is the obvious way to prevent regurgitation. I will warn you though, as a previous attemptor, that the amount of euphoria will scare you to death. You'll be hit with this wave of pleasure that is so intense and insane (I ejaculated too, unexpectedly) and became exponentially and overwhelmingly unbearable until I blacked out. And then I woke up with EMS all over rescuing, I don't want to talk about that part rn.
To get to the point, yes but prepare to die in a supersonic pleasure wave, just don't be dumb and get addicted and turn into a degenerate unless of course you want to, but fair warning as an unintended consequence if the objective goes from a death to dabbling.