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Tyra

Tyra

Pic is from Shawshank Redemption after he escaped.
Jul 22, 2026
316
Or could someone tell me what are known drugs that interact with SN?

For example I know that vitamin C interacts with SN, so you shouldn't eat a candy with SN after.

But I'm worried I'm missing other information.
 
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cowlover1252

cowlover1252

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Aug 21, 2026
95
Are you more interested in learning about drugs that potentiate the effects of SN, drugs that inhibit the effects, or both.

Take this with a grain of salt because it is just something I heard someone else say here, and havent done my own research on it, but I have seen them say that sucking on a hard candy after drinking your SN is okay. Eating gummies or chocolate obviously not, but I could believe a sucker won't hurt. Not sure how valid that all is though.
 
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Carrot

Carrot

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Feb 25, 2025
567
This worries me too. It's not like other medicine will tell you not to combine with SN.

I'm mostly worried about interactions where it explodes, creates something very toxic or causes some other nonsense like that.
 
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unluckysadness

unluckysadness

Enlightened
Jul 9, 2025
1,624
The PPH says you need to fast several hours with only clear liquids (I'm planning to fast for 10-12 hours). I personally don't agree with fasting more than 12 hours because it gives me abdominal pain but everyone is different so I'm just talking for me.

So after your last meal, you should only drink water and nothing else (no candy, no alcohol, no chocolate). I like chewing gum because chewing is known to reduce anxiety, but it could also do some chemical interaction, so I'll not take the risk and avoid chewing gum. I read that only N can be mixed with alcohol.

I'm planning to take 200mg valium 5 minutes before taking SN. But what bothers me if tha PPH which says you must take benzos AFTER SN. I think it's more logical to take benzos BEFORE SN for anxiety. I don't know.
 

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Macedonian1987

Macedonian1987

Just a sad guy from Macedonia.
Oct 22, 2025
1,387
The only reliable info I have about SN interacting with drugs is this: opioids should be avoided with SN because they slow down gastric emptying.
 
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cowlover1252

cowlover1252

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Aug 21, 2026
95
The PPH says you need to fast several hours with only clear liquids (I'm planning to fast for 10-12 hours). I personally don't agree with fasting more than 12 hours because it gives me abdominal pain but everyone is different so I'm just talking for me.

So after your last meal, you should only drink water and nothing else (no candy, no alcohol, no chocolate). I like chewing gum because chewing is known to reduce anxiety, but it could also do some chemical interaction, so I'll not take the risk and avoid chewing gum. I read that only N can be mixed with alcohol.

I'm planning to take 200mg valium 5 minutes before taking SN. But what bothers me if tha PPH which says you must take benzos AFTER SN. I think it's more logical to take benzos BEFORE SN for anxiety. I don't know.
im surprised to hear that the pph says that, since taking benzos after drinking the SN kind of undermines the purpose of it imo. Being calmed down BEFORE drinking CTB-juice sounds a lot more appealing than getting those effects in the middle of it. I am thinking maybe the benzos could increase the chances of throwing up if you take them first so maybe thats why ? Either way I'm going heavy xanax before drinking the sn

Considering chewing gum is a great idea, what is your opinion on drinking the SN, using mouth wash, and then chewing the gum? I'm curious to know if mouth wash is effective at removing the taste,
Or could someone tell me what are known drugs that interact with SN?

For example I know that vitamin C interacts with SN, so you shouldn't eat a candy with SN after.

But I'm worried I'm missing other information.
This worries me too. It's not like other medicine will tell you not to combine with SN.

I'm mostly worried about interactions where it explodes, creates something very toxic or causes some other nonsense like that.


I would definitely like to look more into this topic. These are great questions and hopefully others can chime in or make any corrections here since SN interacting with certain drugs is a new talking point for me. As I am researching some stuff to help me write out this message there is just so much information and so many drugs that have some type of interaction with SN. IThere really is a lot to look at; some of these interactions are major, some are minor.

Fortunately it seems like blood pressure meds actually might increase the absorption of the SN because of the PH change in the stomach acid.

But based on what I have seen so far, here's a list I jotted down on the major drug classes that can cause issues, whether they are major, creating an agonizing CTB experience, or if they'll just make it mildly uncomfortable and recommended to avoid. I haven't looked much at which ones have extreme interactions but it seems a lot of them are on the milder side. It is just so tedious to research SN CTB information without getting those dreaded "You're not alone, reach out for help call xyz number" results all over your search engine:

Anticholinergics (antihistamines, bladder meds)
SSRIs (antidepressants)
SNRIs (antidepressants, again)
Alpha-Blockers (blood pressure meds)
Beta-Blockers (blood pressure meds)
PDE5 Inhibitors (erectile dysfunction meds)
MAOIs (antidepressants)
Statins (cholesterol meds)
Anticoagulants (blood thinners)
Antiplatelets (blood thinners)
Opioids (painkillers)
Diuretics (water pills)
ACE Inhibitors (blood pressure meds)
ARBs (blood pressure meds)
Corticosteroids (steroids)
Thyroid Hormones (thyroid meds)
This worries me too. It's not like other medicine will tell you not to combine with SN.

I'm mostly worried about interactions where it explodes, creates something very toxic or causes some other nonsense like that.
Even though SN has explosive properties, that really is only going to happen in specific conditions like an ignition source, combustion, fuel presence.

When the sodium nitrite combines with your stomach acid it forms nitrous acid, which decomposes into nitrogen dioxide gas and water. Your stomach will not literally explode but if it expands or you experience uncomfortable bloating after ingestion, your stomach can accommodate enough expansion that you won't experience any injuries from it.

It would also be gradual and not instantaneous. Most stomachs can hold up to 2+ liters of fluid/gas before rupturing or injury, and especially if you're fasting before taking it on top of that
This worries me too. It's not like other medicine will tell you not to combine with SN.

I'm mostly worried about interactions where it explodes, creates something very toxic or causes some other nonsense like that.
Even though SN has explosive properties, that really is only going to happen in specific conditions like an ignition source, combustion, fuel presence.

When the sodium nitrite combines with your stomach acid it forms nitrous acid, which decomposes into nitrogen dioxide gas and water. Your stomach will not literally explode but if it expands or you experience uncomfortable bloating after ingestion, your stomach can accommodate enough expansion that you won't experience any injuries from it.

It would also be gradual and not instantaneous. Most stomachs can hold up to 2+ liters of fluid/gas before rupturing or injury, and especially if you're fasting before taking it on top of that
 
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