To follow up on this: Is it okay to take Adderall XR at the same time as the triple dose of 10 mg of Meto before SN 45minutes later?
bipolar22
Student
- Aug 31, 2022
- 103
why would you wanna take a potent stimulant beforehand? to increase panic and feelings of doom and increases chances of then trying to abort?
have a xanax instead my friend
have a xanax instead my friend
Not really. Adderall doesn't give me anxiety nor induce panic for me. I have never experienced that anyways.
AnonymousL
Specialist
- Apr 5, 2023
- 376
I would like to know as well.
In the guide they recommend taking meto a few times before taking the SN?
So why do u think there are negative side effects on it?
In the guide they recommend taking meto a few times before taking the SN?
So why do u think there are negative side effects on it?
The negative side effects are what are called extra pyramidal symptoms like akathesia (shaking hands and feet), dystonia (lock jaw). I believe meto was originally a first generation antipsychotic which at lower doses acts as an antiemetic. It acts by crossing the blood brain barrier. The symptoms are said to be observed at larger doses and higher frequencies. The antidote to these symptoms is said to be diphenhydramine 25 mg. I believe the user jgm63 has made several posts related to this topic.
i took meto(8 hours fasting) for side effects, after 2 to 3 hours i had diarrhea and then felt sleepy. slept for 5 to 6 hours, can be easily disturbed by noises. in short it gives very light sedation.
@bipolar22 can i easily be knocked out without knowing before drinking sn, if i took clonazepam and wait for 30 mins?
@bipolar22 can i easily be knocked out without knowing before drinking sn, if i took clonazepam and wait for 30 mins?
bipolar22
Student
- Aug 31, 2022
- 103
Oh I didn't know that. Try to have 3 times of your normal dose 1 hour before you take your meto. It's important to have good focus so you don't get mixed up. And whenever you feel a bit drowsy from fasting rail a line. Its important to do this right buddy. Good luck. Lemme know how it turns out.
AnonymousL
Specialist
- Apr 5, 2023
- 376
hmm, I just tested it a few hours ago and I have shaky hand all the time but it didn't increase.
No bad effects happend other than using the bathroom way easier than normal xd
So I guess i'm good
How much did you take?
Oh and shaky hands is not your normal shaky hands either.. Its a little more pronounced and non stop like in the videos below..
If yours isn't as bad as this, I guess it should be ok..
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LongForWordlessSong
Member
- Mar 26, 2024
- 44
yeah, wow. Anti emetics seem kind of unnecessary and in Canada impossible to get without a prescription.
I won't be using one for my SN regime
I wouldn't say that.. There's a real chance of vomitting without the antiemetics. If meto is causing concern, domperidone is said to be a viable alternative without the risk of extra pyramidal symptoms as in the case of meto..or perhaps even Olanzapine if one has access to it..
LongForWordlessSong
Member
- Mar 26, 2024
- 44
I cant get it in my country without a prescription
I have weed though which has anti-emetic effects
I remember reading somewhere that weed was not recommended.. You might wanna check that with someone else.. You can't get either meto or domperidone? There are a list of others mentioned on stans guide I think..
Wait I thought I read Canada has some pretty liberal euthanasia laws.. Maybe it could be worth applying..?
AnonymousL
Specialist
- Apr 5, 2023
- 376
I have Meto, but now i see this videos ... 
There antimetics with fewer negative effects to combinate with SN?
I am not familiar with these medications.
There antimetics with fewer negative effects to combinate with SN?
I am not familiar with these medications.
What would be the drug interactions with Adderall and Meto if taking both 1 hour before intaking SN?
I believe the symptoms are said to occur in very rare cases..something like 1 in 500 if memory serves me right.. Another video I saw showed someone saying he took it for about a week when symptoms began showing up and that he wasn't fully able to get rid of the symptoms and some of them have stayed.. It does seem a bit like biting the bullet with these medications to be honest.. I found this video on domperidone..I have Meto, but now i see this videos ...
There antimetics with fewer negative effects to combinate with SN?
I am not familiar with these medications.
Including the jaw lock video, these side effects of meto are looking not so good....
I wonder if these can come from a single dose or a just a stat dose.. I am presuming in most cases these come from higher doses and increased frequency.. I saw a comment from a user on another video that he had heavy legs and muscle cramps from 3x10mg meto.. I am presuming he took this three times on the day rather than a single stat dose.. He said that he had to wait 5 days for the symptoms to go away.. Even this is feel is ok.. What is some cramp gonna do when one is going to ctb? Its the tardive dyskesia, akathesia and dystonia that I am really apprehensive of..
This is the video of the tardive dyskinesia I was referencing above.. The frustrating thing is there is no information about exactly how much meto and at what frequency it was taken that ended up causing the symptoms..
This is another video where Olanzapine is shown to cause similar symptoms.. I was hoping all this while that Olanzapine should probably a good alternative, but the video below shows it may not necessarily be the case..as it is after all an antipsychotic albeit second generation. The person in the video says that the symptoms could occur within the "first few doses" or after an increase in the dose.. Benadryl 25-50 mg is mentioned as an antidote to a dystonic reaction.
A person in the comments section has mentioned that he got these symptoms from a single dose of Haldol (haloperidol).
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If one is concerned about EPS, the single dose method without testing is all that should be utilized. EPS are usually or often irreversible and can develop 24-72 hours after a single dose though more often after repeated doses. EPS are rare, though with the general level of anxiety of most users here, the advice to test meto is the worst advice that could be followed.
I was beginning to think the same thing. if there was any advantage to testing. The question is whether these symptoms can occur within the 40 or 50 minutes before one takes the SN.
The link below says
"Acute dystonia is an acute movement disorder that can result from antipsychotic use. It occurs more commonly with typical antipsychotics, and can affect 3 to 10% of individuals. It can occur either immediately or within days of starting an antipsychotic."
Extrapyramidal Symptoms (EPS)
Extrapyramidal Symptoms (EPS) Primer Extrapyramidal Symptoms (EPS) are drug-induced movement disorders that occur due to antipsychotic blockade of the nigrostriatal dopamine tracts. These blockades can lead to increased cholinergic activity, resulting in acute dystonia, acute akathisia...
EPS symptoms if they are going to appear usually do so after repeated dosing and after 24hours. They are often permanent. I doubt a single dose from stat dose will cause it unless it's repeated at high doses.I was beginning to think the same thing. if there was any advantage to testing. The question is whether these symptoms can occur within the 40 or 50 minutes before one takes the SN.
The link below says
"Acute dystonia is an acute movement disorder that can result from antipsychotic use. It occurs more commonly with typical antipsychotics, and can affect 3 to 10% of individuals. It can occur either immediately or within days of starting an antipsychotic."
Extrapyramidal Symptoms (EPS)
Extrapyramidal Symptoms (EPS) Primer Extrapyramidal Symptoms (EPS) are drug-induced movement disorders that occur due to antipsychotic blockade of the nigrostriatal dopamine tracts. These blockades can lead to increased cholinergic activity, resulting in acute dystonia, acute akathisia...www.psychdb.com
Akathisia from meto?
I attempted to start my SN regimen but was met with some pretty unbearable side effects the day after taking my first few meto doses. I presume it was Akathisia, but I never imagined it would be so brutally uncomfortable and psychologically impacting. Its been two and a half days since then and...
sanctioned-suicide.net
I also think thread is a good read for anyone worried for eps
Thanks for the link. Op says they took 10 mg doses and symptoms occurred on the 3rd dose about 18 hours into the regime. Symptoms could have been a reaction in time to the first dose or possibly because a certain threshold of meto in the system had been exceeded. Op says the symptoms occurred immediately after the third dose.Akathisia from meto?
I attempted to start my SN regimen but was met with some pretty unbearable side effects the day after taking my first few meto doses. I presume it was Akathisia, but I never imagined it would be so brutally uncomfortable and psychologically impacting. Its been two and a half days since then and...
I also think thread is a good read for anyone worried for eps
Post #26 by user allTheDevilsAreHere says that the symptoms occurred 30 mins after taking 3 pills of meto..This technically points to a possible risk with the stat dose even if taken directly before ctb, but the same user says that he was underweight about 48 kgs so possibly the stat dose meto could have been too much for his body weight..
All things considered taking the Stat dose directly without testing seems to be the best option.
In case symptoms prove to be too much, a dose of 25-50 mg diphenhydramine could be kept ready in advance to be taken if required. One will also have to decide in advance if it is better to abort ctb in such circumstances.
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What would be the drug interactions with Adderall and Meto if taking both 1 hour before intaking SN?
The video below presents a case of acute dystonia where benadryl is administered intravenously. The doctor says at the 4 minute mark that he is gonna come back after 5 min. after which the symptoms are shown to have disappeared. I think in oral form, it may take about 40 to 45 min, but the effects as seen here are pretty instantaneous. Perhaps with the syrup, it might cause some sedation.
I guess the experts would have had their reasons recommending meto at that particular dosage. As far as I've seen, the symptoms usually take a few hours to manifest. I haven't seen any case where they do so immediately within the 45 min mark except in the case of the user allTheDevilsAreHere in the thread above.
I believe meto is administered in several euthanasia programs like dignitas for example and I don't think there's any testing there.. I just feel that this subject has been discussed so much and for many it has been a cause of much apprehension and anxiety. I think being prepared in advance and knowing what to do in case symptoms present themselves can be empowering and can allay the fear and anxiety related to this issue to a large extent.
I guess the experts would have had their reasons recommending meto at that particular dosage. As far as I've seen, the symptoms usually take a few hours to manifest. I haven't seen any case where they do so immediately within the 45 min mark except in the case of the user allTheDevilsAreHere in the thread above.
I believe meto is administered in several euthanasia programs like dignitas for example and I don't think there's any testing there.. I just feel that this subject has been discussed so much and for many it has been a cause of much apprehension and anxiety. I think being prepared in advance and knowing what to do in case symptoms present themselves can be empowering and can allay the fear and anxiety related to this issue to a large extent.
The only reason for taking Meto is to avoid nausea after drinking SN, right?
Is there nothing a other posibility to avoid nausea?
Is there nothing a other posibility to avoid nausea?
I am quoting the relevant extract
Extract from Stan's guide
"The second most important step of the method after making the SN drink and swallowing it, is for the SN to stay in your stomach. You are drinking a toxic liquid and your body defences will recognise this and may try to cleanse your body. One of the defence systems is vomiting.
Below is a list of antiemtics in their generic name. Some countries may have a brand name for these drugs:
- Domperidone
- Metoclopramide
- Olanzapine
- Alizapramide
- Chlorpromazine
- Prochlorperazine
Some of you may be on antipsychotics as part of your mental health treatment. If you are any of the below, there is no need to take any antiemetic as they already function as an antiemetic.
Droperidol- 0,25 nM. Benperidol- 0,027 nM. Trifuperidol- 0,4 nM. Spiperone- 0,053 nM. Haloperidol- 2,0. Bromperidol- 2,1. Lurasidone- 1,0 nM. Sestindole- 2,7 nM. Paliperidone- 2,8 nM. Risperidone- 4,9 nM. Olanzapine- 21 nM. Clozapine- 144 nM. Quetiapine- 245 nM"
---------End of extract
In the list of antiemetics mentioned above in Stans's guide all of them are antipsychotics either from the first generation or the second generation with the exception of domperidone. First generation antipsychotics are more prone to cause extrapyramidal symptoms compared to those from the second generation. The mechanism of action of meto and other antipsychotics is different from that of domperidone.
Mechanism of action of metoclopramide
"There's an area in your brain called the vomiting centre, which controls when you feel sick or are sick.
It can be triggered when it receives messages from an area of the brain called the chemoreceptor trigger zone (CTZ).
Metoclopramide works by blocking messages between the CTZ and the vomiting centre. This helps reduce feelings of sickness (nausea) and helps stops vomiting."
Common questions about metoclopramide
NHS medicines information on common questions about metoclopramide.
www.nhs.uk
Mechanism of action of domperidone
"It works by causing the muscles at the top of your stomach to tighten and the muscles at the bottom of your stomach to relax. This makes you less likely to be sick (vomit)."
About domperidone
NHS medicines information on domperidone – what it's used for and key facts.
www.nhs.uk
The pph mentions metoclopramide, domperidone and prochlorperazine. It is noteworthy that the pph does not mention ondansetron in relation to SN. Ondansetron works by blocking serotonin. The pph specifically states that "Dopamine-blocking anti-emetics are the most effective".
As far as I can see from the above, there seem to be only two main alternatives -
1) meto or one of the other antipsychotic based antiemetics
2)domperidone
Meto also seems to have some special capacity in speeding up gastric emptying and is said to help CNS depression.
The caveat is meto, being of the antipsychotic class of medications, may cause drowsiness. Hence the suggestion from some quarters to test it beforehand and if need be switch to domperidone.
I believe meto is regarded as the first choice of antiemetic as it works directly by shutting down part of the brain which is probably why it is so effective. It is also why it may have other undesirable consequences.
If one chooses meto, one will have to reckon with two possibilities
1) occurrence of extrapyramidal symptoms and
2) some degree of drowsiness from CNS depression
in the 45 min wait before taking the SN.
At the end of the day, I think this is a question that requires a bit of probabilistic reasoning. From what I've read so far, the likelihood of extrapyramidal symptoms especially within 45 min period is low. Even if it's there, the likelihood is that it could be mild. Most cases I've seen have reported occurrence of symptoms after a few hours or a day.
The drowsiness is another factor that could make things difficult. One doesn't really know how much and to what degree this can be. It could possibly vary from person to person. The worst I read was a comment from one person saying their legs got a bit heavy and they got some muscle cramps. I guess one has to keep both of these factors in mind and make a determination if one is capable of going through the act at the 45 min mark.
If symptoms are too pronounced, drowsiness is too heavy, there is the option of taking diphenhydramine kept ready in advance and aborting the ctb.
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Anyone have any ideas?
What would be the drug interactions with Adderall and Meto if taking both 1 hour before intaking SN?
What would be the drug interactions with Adderall and Meto if taking both 1 hour before intaking SN?
I don't know what exactly what the interaction would be...but on first look, I would say that it is not recommended..
Meto belongs to the class of antipsychotics and is known to cause CNS (central nervous system) depression, whereas Adderall is a stimulant. They both work in opposite directions. Its like taking caffeine or sugar with benzos. In a normal sense, I've read there was a danger to heart health.. But I don't really know what the implications are in a ctb scenario..
The following study says that there is a practice of using them together but advises caution..
I also found the following line in the study which could be a cause for concern.
"Going beyond theoretical implications, research has shown that stimulants and antipsychotics actually do block the effects of each other."
If the Adderall cancels out the anti nausea effect of meto, it might no longer prevent vomitting from taking place.
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