Method vitamin overdose study (monkeys)

[busybee]

I came across a study on vitamin overdose in monkeys. Sadly they don't say how fast the monkeys passed.

I wonder if, at least for the retinol, it could be taken in via the skin. I know that pregnant people shouldn't use skincare with retinol so that would imply that this could potentially work. That way it couldn't be vomited up or pumped out.

A lethal hypervitaminosis A syndrome in young monkeys (Macacus fascicularis) following a single intramuscular dose of a water-miscible preparation containing vitamins A, D2 and E - PubMed

Large intramuscular doses of a water-miscible preparation of vitamin A (500,000 I.U. retinyl acetate/ml), vitamin E (50 I.U./ml) and vitamin D2 (50,000 I.U./ml) were administered to young monkeys (Macacus fascicularis) weighing 1-1.8 kg. At vitamin A doses equivalent to 200 mg retinol/kg or...

pubmed.ncbi.nlm.nih.gov

 

[saddestbunny]

interesting, keep in mind they were less than 5 pounds from what I see

to affect a human in the same way might require a LOT more because of body mass, but unsure without reading more into it


they also mention:

"These immediate signs were first noted 3-35 minutes after injection. Following apparent recovery at 1-2 hrs, longer term signs of toxicity, such as decreased activity, malaise, drowsiness, loss of appetite, loss of weight, and itchiness of the skin, appeared within 1-6 days, depending on the dose. Monkeys receiving the highest lethal doses became progressively weaker, showed labored breathing, lapsed into a coma, lost simple reflexes and then died. Respiratory failure usually preceded the cessation of heart beat. In some monkeys on a lower but lethal dose, death was preceded by generalized convulsive seizures."

means only the highest dosed monkeys died and it took a while, up to 35 min, the others survived with those side effects mentioned

since you can die from basically overloading your body with anything I'm not sure how viable this is but incredibly interesting

 

[Justnotme]

It sounds painful... Convulsive seizures

 

[busybee]

interesting, keep in mind they were less than 5 pounds from what I see

to affect a human in the same way might require a LOT more because of body mass, but unsure without reading more into it


they also mention:

"These immediate signs were first noted 3-35 minutes after injection. Following apparent recovery at 1-2 hrs, longer term signs of toxicity, such as decreased activity, malaise, drowsiness, loss of appetite, loss of weight, and itchiness of the skin, appeared within 1-6 days, depending on the dose. Monkeys receiving the highest lethal doses became progressively weaker, showed labored breathing, lapsed into a coma, lost simple reflexes and then died. Respiratory failure usually preceded the cessation of heart beat. In some monkeys on a lower but lethal dose, death was preceded by generalized convulsive seizures."

means only the highest dosed monkeys died and it took a while, up to 35 min, the others survived with those side effects mentioned

since you can die from basically overloading your body with anything I'm not sure how viable this is but incredibly interesting

Ohh that's how to read it. Thanks!
The "300 mg retinol/kg" mentioned at the bottom would still be in the gram range if my math isn't too far off
Issue is that this was injected so the oral dose would differ

• Oral: LD50 Mouse oral 2570 mg/kg (10 day)
• Oral LD50 4980 mg/kg (rat)

Found via opening retinol msds (most open into pdfs and I don't know how to link that)

so the dose via skin would be even higher...

 

[todienomore]

Hypermagnesemia - Magnesium Overdose

Fatal Hypermagnesemia Due to Laxative Use: Case Report and Review of the Literature https://sci-hub.se/10.1016/j.amjms.2017.08.013 Hypermagnesemia-induced fatality following epsom salt gargles https://sci-hub.se/10.1016/S0736-4679(01)00462-0 Pros: Epsom Salts are readily available at any...

sanctioned-suicide.net