Sorry, this is a bit messy.
https://www.drugs.com/ppa/pentobarbital.html
Pharmacology
Barbiturate with sedative, hypnotic, and anticonvulsant properties. Barbiturates depress the sensory cortex, decrease motor activity, alter cerebellar function, and produce drowsiness, sedation, and hypnosis. In high doses, barbiturates exhibit anticonvulsant activity; barbiturates produce dose-dependent respiratory depression; reduce brain metabolism and cerebral blood flow in order to decrease intracranial pressure
Krauss 2006: Children and Adults: Sedation: IM: 10 to 15 minutes; IV: Almost immediate, within 3 to 5 minutes; Oral, Rectal: 15 to 60 minutes
The LD50: various animals, mouse 170 mg/kg, dog 80 mg/kg, rat 125 mg/kg. Human: varying from 36 mg/kg,
I don't know the source http://absolutewrite.com/forums/archive/index.php/t-106250.html
'If you look up the MSDS (Material Safety Data Sheet) for it, it gives the LD50 as ~120 mg/kg body mass. That means that half of a group of rats died from an oral dose of 120 mg per kg of mass. Which, if we assume that can be extrapolated to humans, means a dose of ~12g for a 220 lb person would have a 50:50 chance of killing him. That's probably about 10-12 mL, depending on the density.'
Lots of sources, different numbers. If it were 12 gr for LD50 it would be disappointing, considering that LD50 means.
It's also a bit odd that soem sources have many people dying so fast, when here the onset of action is indicated as 15 to 60 min.
Done properly, it should work for peopel with no tolerance.
I know this post is a mess, but I'll leave it at that.
https://www.drugs.com/ppa/pentobarbital.html
Pharmacology
Barbiturate with sedative, hypnotic, and anticonvulsant properties. Barbiturates depress the sensory cortex, decrease motor activity, alter cerebellar function, and produce drowsiness, sedation, and hypnosis. In high doses, barbiturates exhibit anticonvulsant activity; barbiturates produce dose-dependent respiratory depression; reduce brain metabolism and cerebral blood flow in order to decrease intracranial pressure
Krauss 2006: Children and Adults: Sedation: IM: 10 to 15 minutes; IV: Almost immediate, within 3 to 5 minutes; Oral, Rectal: 15 to 60 minutes
The LD50: various animals, mouse 170 mg/kg, dog 80 mg/kg, rat 125 mg/kg. Human: varying from 36 mg/kg,
I don't know the source http://absolutewrite.com/forums/archive/index.php/t-106250.html
'If you look up the MSDS (Material Safety Data Sheet) for it, it gives the LD50 as ~120 mg/kg body mass. That means that half of a group of rats died from an oral dose of 120 mg per kg of mass. Which, if we assume that can be extrapolated to humans, means a dose of ~12g for a 220 lb person would have a 50:50 chance of killing him. That's probably about 10-12 mL, depending on the density.'
Lots of sources, different numbers. If it were 12 gr for LD50 it would be disappointing, considering that LD50 means.
It's also a bit odd that soem sources have many people dying so fast, when here the onset of action is indicated as 15 to 60 min.
Done properly, it should work for peopel with no tolerance.
I know this post is a mess, but I'll leave it at that.
