Nobody talks about how ondansteron (Zofran) can be helpful?

[Kta1994]

It reduces nausea and chances of vomiting, cant we use it along with meto?

 

[Guy Smiley]

Ondansetron is a serotonin receptor antagonist, while metoclopramide is a dopamine receptor antagonist. I don't understand the biology/physiology behind it, but for some reason only dopamine receptor antagonists help with the nausea caused by SN.

 

[dying flower]

Ondansetron is a serotonin receptor antagonist, while metoclopramide is a dopamine receptor antagonist. I don't understand the biology/physiology behind it, but for some reason only dopamine receptor antagonists help with the nausea caused by SN.

I only have ordansetron, weed and some oxycodene. Do you think this would work as an SN plan?

 

[Ambivalent1]

Why did you have to upset that girl with the bear in her profile picture? :(

 

[Guy Smiley]

I only have ordansetron, weed and some oxycodene. Do you think this would work as an SN plan?

I don't think any of those will help you to not vomit. For that, you really want a dopamine receptor antagonist such as metoclopramide.

 

[Kta1994]

Ondansetron is a serotonin receptor antagonist, while metoclopramide is a dopamine receptor antagonist. I don't understand the biology/physiology behind it, but for some reason only dopamine receptor antagonists help with the nausea caused by SN.

So its useless for nausea in general?

 

[Guy Smiley]

So its useless for nausea in general?

No, it's quite useful for nausea in certain situations.

"Ondansetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation therapy. It is also used to prevent nausea and vomiting that may occur after surgery."

I'm not sure why it's not useful for SN. I read that on SaSu. Also, it's not one of the recommended antiemetics listed in the PPH, so I assume that whoever said it on SaSu knows what they are talking about.

 

[LifeIsCrazyNemb]

You can combine both medications Metoclopramide + ondansetron.

 

[anxiousguineapig]

I have yet to read any actual scientific explanation for why ondansetron is inadequate. It does work via a different route but I wonder how much of the view that it's pointless is actually supported vs just something people repeat. That said it's not very difficult to get meto. I'm going to ask my doctor for it in a few days because I was prescribed ondansetron for chronic nausea but it turns out to not be covered by insurance while meto is, and there are also online websites that sell it without a prescription. It's not a controlled substance so it's pretty straightforward to buy without going on the dark web afaik.

 

[Endisclose]

You can combine both medications Metoclopramide + ondansetron.

View attachment 133072

This is interesting as the version of the pph I downloaded from this website is also from 2022 and says that it has removed the recommendation of both nexium and propranolol from the protocol.. Btw propranolol is available only in 40 mg per tablet so 400 mg would mean 10 tablets..Add the 3 of meto, 1 of ondansetron.. I wonder if this many tablets are advisable just 40 minutes prior to taking the SN with all the water it might take .

 

[Kta1994]

You can combine both medications Metoclopramide + ondansetron.

View attachment 133072

Thanks thats what im gonna do

 

[wait.what]

I have yet to read any actual scientific explanation for why ondansetron is inadequate.

I know this much: meto speeds up gut motility, and is sometimes prescribed for gastroparesis (slowed stomach emptying). That much is verifiable

Now, I read on SaSu that meto is preferable as an antiemetic for the SN method because it both combats nausea and moves the SN to the small intestine quicker. You can't throw up what is no longer in your stomach. I don't believe the PPeH has ever said any such thing (correct me if I'm wrong), but it does make intuitive sense.

By contrast, ondansetron slows gut movement down, increasing the amount of time things stay in the stomach. I don't know for sure if slower movement of SN through the gut increases the odds of vomiting, either in general or when compared to metoclopramide. Drugs sometimes act in ways you wouldn't expect. But if ondansetron is not recommended for the SN regimen, it could be because ondansetron makes the SN stay in the stomach longer.

 

[WaitingAllMyLife]

I know this much: meto speeds up gut motility, and is sometimes prescribed for gastroparesis (slowed stomach emptying). That much is verifiable

Now, I read on SaSu that meto is preferable as an antiemetic for the SN method because it both combats nausea and moves the SN to the small intestine quicker. You can't throw up what is no longer in your stomach. I don't believe the PPeH has ever said any such thing (correct me if I'm wrong), but it does make intuitive sense.

By contrast, ondansetron slows gut movement down, increasing the amount of time things stay in the stomach. I don't know for sure if slower movement of SN through the gut increases the odds of vomiting, either in general or when compared to metoclopramide. Drugs sometimes act in ways you wouldn't expect. But if ondansetron is not recommended for the SN regimen, it could be because ondansetron makes the SN stay in the stomach longer.

I found this surprising so just googled it and the top results all said that ondansetron does not affect gastric motility.

 

[Kta1994]

I know this much: meto speeds up gut motility, and is sometimes prescribed for gastroparesis (slowed stomach emptying). That much is verifiable

Now, I read on SaSu that meto is preferable as an antiemetic for the SN method because it both combats nausea and moves the SN to the small intestine quicker. You can't throw up what is no longer in your stomach. I don't believe the PPeH has ever said any such thing (correct me if I'm wrong), but it does make intuitive sense.

By contrast, ondansetron slows gut movement down, increasing the amount of time things stay in the stomach. I don't know for sure if slower movement of SN through the gut increases the odds of vomiting, either in general or when compared to metoclopramide. Drugs sometimes act in ways you wouldn't expect. But if ondansetron is not recommended for the SN regimen, it could be because ondansetron makes the SN stay in the stomach longer.

Ondansetron had no significant effect on the gastric half-emptying time with and without a lag phase compared with placebo in this crossover study (Figure 1).11 de jan. de 2002

 

[Endisclose]

The pph I downloaded from this website(year 2022), recommends ondansetron (8 mg + 20 mg meto) for the DDMAPh mix stating it can enhance the effect of meto, but has left it out in the case of SN..wonder why? ..And also are there like two versions of the pph..I am not able to find the page shared by @LifeIsCrazyNemb in the pph available to download on the sticky thread, which is ostensibly from the same year 2022..

 

[dying flower]

I have yet to read any actual scientific explanation for why ondansetron is inadequate. It does work via a different route but I wonder how much of the view that it's pointless is actually supported vs just something people repeat. That said it's not very difficult to get meto. I'm going to ask my doctor for it in a few days because I was prescribed ondansetron for chronic nausea but it turns out to not be covered by insurance while meto is, and there are also online websites that sell it without a prescription. It's not a controlled substance so it's pretty straightforward to buy without going on the dark web afaik.

I haven't been able to find it online without a prescription

 

[LifeIsCrazyNemb]

The pph I downloaded from this website(year 2022), recommends ondansetron (8 mg + 20 mg meto) for the DDMAPh mix stating it can enhance the effect of meto, but has left it out in the case of SN..wonder why? ..And also are there like two versions of the pph..I am not able to find the page shared by @LifeIsCrazyNemb in the pph available to download on the sticky thread, which is ostensibly from the same year 2022..

Suicide Resource Compilation

All the links to threads, videos, audio, downloads, and information found here are being made available only for educational purposes, and have been shared by users; we cannot assure the accuracy of the data. This means the way you use this data is fully your responsibility, that you need to...

sanctioned-suicide.net

 

[Endisclose]

Suicide Resource Compilation

All the links to threads, videos, audio, downloads, and information found here are being made available only for educational purposes, and have been shared by users; we cannot assure the accuracy of the data. This means the way you use this data is fully your responsibility, that you need to...

sanctioned-suicide.net

View attachment 133232

Sorry... I checked the link, but I got a resource not available message.. I also got some weird porno stuff on the page after I clicked the link.. I just hope my phone hasn't been infected or anything.. . I ran a preliminary check, things look OK as of now.. Wish the files were hosted somewhere cleaner..

 

[wait.what]

I found this surprising so just googled it and the top results all said that ondansetron does not affect gastric motility.

I got that from a convo with my doctor, the context being potential problems caused by a slow-moving GI tract in general. He felt that ondansetron could worsen the problem, particularly if you take a lot of it, which I do, for reasons that are not currently relevant.

Possibilities:

1) Ondansetron only slows motility in the lower gut, which is plausible, given that constipation is listed as a common side effect.
2) I totally misunderstood what the doc was saying, aside the general suggestion that I not eat ondansetron pills like Pez.
3) My doctor is old and smokes crack. I always wondered why his parking lot was covered in those little glass pipes … (Ok, I made up that last part.)

 

[Endisclose]

Maybe it's better to stick just to meto for the SN method. The pph simply states dopamine-blocking antiemetics are most effective in the chapter on SN. Ondansetron may be effective in other cases like the DDMAPh (5 drug cocktail) where the pph advises to combine with meto (20 mg meto + 8 mg ondansetron).

If meto causes extra pyramidal symptoms or if one is unwilling to risk them, one can always go with domperidone. And if one feels that it may not be as effective as meto, maybe it can be coupled with Olanzapine.. So I guess there are enough options in terms of antiemetics for the SN method.