
rotciv
Something In The Way
- Mar 25, 2023
- 632



They say that analgesia occurs between blood concentration values of 1ng/ml to 2ng/ml, and 10ng/ml to 20ng/ml for general anesthesia and deep respiratory depression, so 10 times more.
The 70% bioavailability of 1200 micrograms (1.2mg) of this product reaches 2ng/ml for analgesia, so 12000mcg (12mg) of this product with 70% bioavailability would be needed to cause respiratory depression, but focusing only on oral bioavailability values which they say is 20%, it would take 40000mcg (40mg) swallowed to start a profund respiratory depression. I don't advise oral though because one of the side effects of opioids is vomiting.
This would be about 8mg intravenously for start a profound respiratory depression. I don't have a defined table for the percentage of bioavailability because not all routes are that detailed studied, but I do have one in order of bioavailability. I just didn't include the sublingual because the dose will never be fully used by this route, because most of it will be swallowed via the intestinal route (unless you have this type of mouth patches).
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