Meto isn't even more effective than domperidone?

[Mbound]

This is like my 4th post about anti-e's lol, but according to a randomized clinical study on pubmed of 95 adults, there's no clinical difference in how well domperidone and meto control nausea.

And meto carries a significant risk of causing akathisia and just seems to generally make people feel like shit. Is the reason it's recommended because people still think it's more effective, or just because it's a bit more widely available (or was until recently)?

I'm thinking at this point I'm not even gonna use meto and am just going with 2 days of domperidone+zofran and a stat dose of the same.

 

[Thorn]

I have taken it, no side effects worth mentioning, and I always feel like shit. It may well be just about manufacturers and marketing.

 

[Exit_charge]

I'm also considering domperidone instead. Reading people's stories about meto really put me off. My pharmacist told me it's just as effective as meto.

 

[Mbound]

I'm also considering domperidone instead. Reading people's stories about meto really put me off. My pharmacist told me it's just as effective as meto.

From what I've read, it seems like domperidone does everything meto does in regards to the dopamine receptors/nausea, but without crossing the blood brain barrier and therefore causing the neurological side effects. I think meto's popularity is due to its use by Exit and Dignitas (90% sure both of them use it as a stat dose before N)

 

[onlyinsleep]

Anyone know what resource I look at to figure out my stat dosing for SN and when to take Benzos etc. etc.? I didn't see it in the main SN thread post.

 

[Superfluous]

This is like my 4th post about anti-e's lol, but according to a randomized clinical study on pubmed of 95 adults, there's no clinical difference in how well domperidone and meto control nausea.

And meto carries a significant risk of causing akathisia and just seems to generally make people feel like shit. Is the reason it's recommended because people still think it's more effective, or just because it's a bit more widely available (or was until recently)?

I'm thinking at this point I'm not even gonna use meto and am just going with 2 days of domperidone+zofran and a stat dose of the same.

Could you post the link please? I'm very interested in this subject and am trying to find as much data as possible.

 

[Mbound]

Could you post the link please? I'm very interested in this subject and am trying to find as much data as possible.

Sure, here it is:

https://www.ncbi.nlm.nih.gov/pubmed/1810356

What's interesting is it also notes no difference in the severity of side effects. But yeah this is the only clinical study I found directly comparing them.

 

[Superfluous]

Thanks. I've been searching for a while now trying to find good data.

Here's a good source for the pharmacodynamic properties of Domperidone:

Domperidone 10mg Tablets - Summary of Product Characteristics (SmPC) - (emc)

Domperidone 10mg Tablets - Summary of Product Characteristics (SmPC) by Aurobindo Pharma - Milpharm Ltd.

www.medicines.org.uk

Unfortunately, whilst the same site also provides details for Metoclopramide, it's not nearly as detailed:

Metoclopramide 10mg Tablets - Summary of Product Characteristics (SmPC) - (emc)

Metoclopramide 10mg Tablets - Summary of Product Characteristics (SmPC) by Accord-UK Ltd

www.medicines.org.uk

 

[Superfluous]

@Mbound Is there further detail beyond the abstract? Would I need to sign up to see it if there is?

 

[bilamajina]

@Superfluous, if you are unable to access the full article, @cornflowerblue may be able to help - "I can access most medical journals through the databases at my public library ". See post here. @cornflowerblue has concerns regarding Metoclopramide and extrapyramidal symptoms.

 

[LaBrava]

How easy is it to get domperidone?

 

[rata1]

i just ordered it on a "legal" site. more expensive than in a normal farmacy, but worked. i'm in europe

 

[Superfluous]

It's OTC where I live.

@Superfluous, if you are unable to access the full article, @cornflowerblue may be able to help - "I can access most medical journals through the databases at my public library ". See post here. @cornflowerblue has concerns regarding Metoclopramide and extrapyramidal symptoms.

Thanks for the info.

I'm planning on starting a domperidone ahead regimen within the next few days, and am in the process of composing a post to detail my regimen and report back progress.

@cornflowerblue, would you consider starting a conversation with me? I can't access your profile.

 

[LaBrava]

It's OTC where I live.

Thanks for the info.

I'm planning on starting a domperidone ahead regimen within the next few days, and am in the process of composing a post to detail my regimen and report back progress.

I'll be interested to read this.

 

[KnightOfEnceladus]

Domperidone has a chance of causing long QT syndrome, from what I've read, which metoclopramide doesn't...in any case, either should be fine for a stat dose, just make sure you have everything else prepared and ready to go first.

 

[jake3d]

Domperidone has a chance of causing long QT syndrome

Only with prolonged administration (months).

 

[Superfluous]

Domperidone has a chance of causing long QT syndrome, from what I've read, which metoclopramide doesn't...in any case, either should be fine for a stat dose, just make sure you have everything else prepared and ready to go first.

Yes. I'm basing my regimen on a QT interval study and will post all relevant links.

Edit: Just realised I posted the link to the study earlier in this thread