Combining AE's for SN and side effects: Metoclopramide, Ondansetron, Domperidone

[Zardoz]

Hi all
I have a couple of questions on using prescription antiemetics with SN:

1. Does anyone have any experience of combining prescription antiemetics for use with SN?
The PPH recommends 3x10mg of Metoclopramide (Maxolon) for the standard SN method, and 20mg Meto combined with 8mg of Ondansetron (Zofran) for the "5 drug mix" method.
I'm guessing that the combination of the two would be preferred? As the PPH says:
"There are two recommended anti-emetics drugs that should be taken together: Meto and Ondansetron. ...". And explains how the Ondansetron compliments the Meto.

2. Does anyone have any experience of taking these and the side effects of either of them?
I have both Meto and Ondansetron (turns out was v.easy to get via online pharmacies here in the UK).
I tried a normal dose of each separately, 10mg Meto and 4mg Ondansetron:
The Meto make a little edgy/shaky, anxious perhaps, and I think drowsy. I drink alcohol (and will if/when I CTB) and this is one of things the advice says not to mix with Meto, as it can knock you out badly and you may have trouble waking up (and what's the problem lol). Can't see any mention of actual coma or long term damage from this though. I'm just worried that if I take a large dose of Meto on top of alcohol it will knock me out before I get to the SN, and just then have the fallout of an OD of Meto/alcohol to deal with instead.
The Ondansetron gave me a mild headache but nothing serious.
So I think I'm gonna go with the 20mg Meto and 8mg Ondansetron combined.

3. Domperidone
I don't have but could probably also get Domperidone (Motilium).
Does anyone have any experience of taking this? side effects, etc.
I won't bother sourcing it unless it's notably preferred to Meto or Ondansetron for any reason. It seems to be similar to Meto in its effect? Perhaps more alcohol friendly? Idk.

Any recommendations for any other AE's? (available in UK, prescription-only is probably Ok).

I know the advice about not mixing alcohol with SN and AE's, it's a risk I am going to have to take.

Thanks a lot

 

[Ambien addict]

Hi all
I have a couple of questions on using prescription antiemetics with SN:

1. Does anyone have any experience of combining prescription antiemetics for use with SN?
The PPH recommends 3x10mg of Metoclopramide (Maxolon) for the standard SN method, and 20mg Meto combined with 8mg of Ondansetron (Zofran) for the "5 drug mix" method.
I'm guessing that the combination of the two would be preferred? As the PPH says:
"There are two recommended anti-emetics drugs that should be taken together: Meto and Ondansetron. ...". And explains how the Ondansetron compliments the Meto.

2. Does anyone have any experience of taking these and the side effects of either of them?
I have both Meto and Ondansetron (turns out was v.easy to get via online pharmacies here in the UK).
I tried a normal dose of each separately, 10mg Meto and 4mg Ondansetron:
The Meto make a little edgy/shaky, anxious perhaps, and I think drowsy. I drink alcohol (and will if/when I CTB) and this is one of things the advice says not to mix with Meto, as it can knock you out badly and you may have trouble waking up (and what's the problem lol). Can't see any mention of actual coma or long term damage from this though. I'm just worried that if I take a large dose of Meto on top of alcohol it will knock me out before I get to the SN, and just then have the fallout of an OD of Meto/alcohol to deal with instead).
The Ondansetron gave me a mild headache but nothing serious.
So I think I'm gonna go with the 20mg Meto and 8mg Ondansetron combined.

3. Domperidone
I don't have but could probably also get Domperidone (Motilium).
Does anyone have any experience of taking this? side effects, etc.
I won't bother sourcing it unless it's notably preferred to Meto or Ondansetron for any reason. It seems to be similar to Meto in its effect? Perhaps more alcohol friendly? Idk.

Any recommendations for any other AE's? (available in UK, prescription-only is probably Ok).

I know the advice about not mixing alcohol with SN and AE's, it's a risk I am going to have to take.

Thanks a lot

I can't get meto..I have zofran alone..will that be okay? haven't bought antacids yet, Still don't have a scalle, testing strips, etc. Have benzos..too stupid to read the whole process..Do I need distilled water or can I use bottled water?

 

[cowboypants]

I would skip the alcohol. Meto and ondansetron is all you need for antiemetics is concerned. They stopped mentioning ondansetron in recent PPH version but I will still take it.

 

[Zardoz]

I would skip the alcohol. Meto and ondansetron is all you need for antiemetics is concerned. They stopped mentioning ondansetron in recent PPH version but I will still take it.

Thanks for the reply.
I would skip the alcohol if I could, i know the standard advice, but realistically it's not optional for me. Is partly why I want to get the antiemetics right.
Ondansetron is recommended in the 5 drug mix method (in combination with meto) but meto only for SN method in the latest PPH Jan 2025. Are you saying previous versions recommended ondansetron for SN also?
I don't suppose it makes a lot of difference in the grand scheme of things.

I'm also interested in anyones experiences from actually taking any of these, side effects they had or not, etc.

 

[fedup1982]

I had bad experience with all antiemetics ordered from online pharmacies that don't need a prescription; they all seemed to be fake pills since they just didn't work for me

 

[Zardoz]

I had bad experience with all antiemetics ordered from online pharmacies that don't need a prescription; they all seemed to be fake pills since they just didn't work for me

Thanks.
I'm intereated peoples experiences with the prescription ones I mentioned. I have these via online precriptions. They seem legit. Side effects were as expected.
Personally i wouldnt put much value on non-prescription antiemetics, i think the good stuff is precription only.

 

[fedup1982]

Thanks.
I'm intereated peoples experiences with the prescription ones I mentioned. I have these via online precriptions. They seem legit. Side effects were as expected.
Personally i wouldnt put much value on non-prescription antiemetics, i think the good stuff is precription only.

You'd be surprised. I ordered ondansetron, cyclizine, meto and domperidone all without prescription and none of them helped with nausea.

 

[Zardoz]

You'd be surprised. I ordered ondansetron, cyclizine, meto and domperidone all without prescription and none of them helped with nausea.

Hmm, ok. Do you think they were fake/dud or are you saying that these meds just don't work for you?
I ordered mine with a prescription. These are only available legally in the UK with a prescription.
Are you in a different country where these are available without a precription? or you obtained them under the radar?
Mine seem real, the pharmacies seem legit. I had to do an ID verification and online 'consultancy' for a doctor to do the prescription for them. The meds seem potent, I had the predictable side effects, but I have not made myself nauseous to test them with that.

 

[fedup1982]

Hmm, ok. Do you think they were fake/dud or are you saying that these meds just don't work for you?
I ordered mine with a prescription. These are only available legally in the UK with a prescription.
Are you in a different country where these are available without a precription? or you obtained them under the radar?
Mine seem real, the pharmacies seem legit. I had to do an ID verification and online 'consultancy' for a doctor to do the prescription for them. The meds seem potent, I had the predictable side effects, but I have not made myself nauseous to test them with that.

I doubt it was my physiology since not one of the 5 antiemetics worked for me. You'd have thought at least 1 or 2 would have worked. I'm pretty sure they were fakes without any of the active ingredients they claimed to have. I'm in the UK, I had to order them from pharmacies abroad that don't need prescriptions for any of the medications they sold that normally would need a prescription.

 

[Zardoz]

I doubt it was my physiology since not one of the 5 antiemetics worked for me. You'd have thought at least 1 or 2 would have worked. I'm pretty sure they were fakes without any of the active ingredients they claimed to have. I'm in the UK, I had to order them from pharmacies abroad that don't need prescriptions for any of the medications they sold that normally would need a prescription.

Good to know, thanks for the info.

Yes you'd expect to get something off some of them. I would expect this of OTC antiemetics perhaps (I posted about this previously, i found a couple that i havent tried and wont bother now i have meto etc).

I'm UK and I managed to order meto and ondanseteon online Ok. I perhaps wasn't as truthful as i probably should have been in the online consultation (coughs). If I'd been 100% truthful they wouldnt have prescribed it. Is why my main GP almost certainly wouldnt either (just other meds and medical conditions, nothing to do with CTB, and i have no legitimate need for them). I had to give consent for them to contact my GP if they wanted to, I gave them an old GP details (not my current GP) and took a chance they wouldn't contact them. I assume they didn't, the meds were approved and shipped the next day. You can only order a small amount at a time. If I got caught I was going to say it was a test for research I'm doing into the online pharmacy business.
I did this with 2 separate online pharmacies, meto from one and ondansetron from another.
Idk your situation but you could try the same approach maybe, if you can of course.

 

[Alexandra_]

I'm guessing that the combination of the two would be preferred? As the PPH says:
"There are two recommended anti-emetics drugs that should be taken together: Meto and Ondansetron. ...". And explains how the Ondansetron compliments the Meto.

Could you give me the link please?

I started having terrible unbearable side effects from Metoclopramide. I threw it away, it didn't work for me

 

[Zardoz]

Could you give me the link please?

I started having terrible unbearable side effects from Metoclopramide. I threw it away, it didn't work for me

What side effects did you experience, if you don't mind me asking?

The PPH is sticked on the main discussion forum page:

PPH January 2025

https://bunkr.media/f/oYjGxZpe48cWo (link has no preview, new hoster) Edit: April 2025, fixed the links. Edit 2: if you don't already use one and the link doesn't work and just gives porn sites, try with an adblock. Edit 3: for PHH Essentials 2022...

sanctioned-suicide.net

 

[Alexandra_]

What side effects did you experience, if you don't mind me asking?

The PPH is sticked on the main discussion forum page:

PPH January 2025

https://bunkr.media/f/oYjGxZpe48cWo (link has no preview, new hoster) Edit: April 2025, fixed the links. Edit 2: if you don't already use one and the link doesn't work and just gives porn sites, try with an adblock. Edit 3: for PHH Essentials 2022...

sanctioned-suicide.net

I was simply in an unbearable state. I can't describe it in words. It was worse than vomiting. I felt very bad, my whole body was twitching - my head, my arms, I was aching, I was bending over. It was like a very strong withdrawal. I bought the drug without a prescription. Never before have I experienced such terrible side effects from any pills

 

[derekWest]

I was simply in an unbearable state. I can't describe it in words. It was worse than vomiting. I felt very bad, my whole body was twitching - my head, my arms, I was aching, I was bending over. It was like a very strong withdrawal. I bought the drug without a prescription. Never before have I experienced such terrible side effects from any pills

Me too... horrible.. a lot of anxieties

 

[Zardoz]

I was simply in an unbearable state. I can't describe it in words. It was worse than vomiting. I felt very bad, my whole body was twitching - my head, my arms, I was aching, I was bending over. It was like a very strong withdrawal. I bought the drug without a prescription. Never before have I experienced such terrible side effects from any pills

That sounds horrific. Sorry to hear that. This could have been the "extrapyramidal" reaction that can happen from meto? (and other antiemtics apparently).
When you say you got it without a prescriprion, are they legal/legit or could they have been counterfeit?

Me too... horrible.. a lot of anxieties

Thanks for the info.
I def felt shaky on one 10g tablet of meto, anxious yes. Bit like a comedown/withdrawal of nothing specific. Not nice, but not so bad i wouldnt take it again as a one off.
I think meto is one of the worse of rhe common ones for bad reactions, is partly why I'd like to minimise the dose and use another as well in combo.
The ondansetron seemed much better in this respect, just a very mild headache otherwise i felt normal.
Like all new druga, side effects normally subside if you persevere with them. But i don't want to have to build up a tolerance to antiemetics on top of everything else that needs planning/sorting out.

 

[Alexandra_]

That sounds horrific. Sorry to hear that. This could have been the "extrapyramidal" reaction that can happen from meto? (and other antiemtics apparently).
When you say you got it without a prescriprion, are they legal/legit or could they have been counterfeit?

Thanks for the info.
I def felt shaky on one 10g tablet of meto, anxious yes. Bit like a comedown/withdrawal of nothing specific. Not nice, but not so bad i wouldnt take it again as a one off.
I think meto is one of the worse of rhe common ones for bad reactions, is partly why I'd like to minimise the dose and use another as well in combo.
The ondansetron seemed much better in this respect, just a mild headache otherwise i felt normal.
Like all new druga, side effects normally subside if you persevere with them. But i don't want to have to build up a tolerance to antiemetics on top of everything else that needs planning/sorting out.

Thank you. Yes, that was exactly the reaction. It's hard for me to write about it. In my country, these pills are sold without a prescription. I took 1 pill and 8 hours later another pill, then the symptoms appeared and did not go away for a long time

Are you talking about the SN method?

 

[Zardoz]

Thank you. Yes, that was exactly the reaction. It's hard for me to write about it. In my country, these pills are sold without a prescription. I took 1 pill and 8 hours later another pill, then the symptoms appeared and did not go away for a long time

Are you talking about the SN method?

Yes, I want the antiemetics for SN CTB.
I'm wary of taking a high dose of meto like the 3x10mg the standard protocols advise. It doesnt mix well with alcohol too apparently, and i dont mix well without alcohol lol.
Is that a medical emergency when that reaction happens? Did you just sit it out, or seek help?
Dont say if you'd rather not go into it, thats absolutely fine, and thanks your help.

 

[cowboypants]

Thanks for the reply.
I would skip the alcohol if I could, i know the standard advice, but realistically it's not optional for me. Is partly why I want to get the antiemetics right.
Ondansetron is recommended in the 5 drug mix method (in combination with meto) but meto only for SN method in the latest PPH Jan 2025. Are you saying previous versions recommended ondansetron for SN also?
I don't suppose it makes a lot of difference in the grand scheme of things.

I'm also interested in anyones experiences from actually taking any of these, side effects they had or not, etc.

Yeah the publicly available 2021/22 PPH versions used to have both meto and ondansetron. They both target different parts of the brain/ receptors. Although meto covers a lot of stuff. Those two are the main ones

 

[PepperJam]

Me too... horrible.. a lot of anxieties

Found this thread after experiencing the same thing. Shortly after taking my meto in an attempt to enact my plan, it felt like I was having an incredibly severe panic attack, even though I had already taken a benzo earlier that day (my normal prescription). After that, I was uncontrollably shaking for about an hour and found it incredibly hard to breathe. It also seemed to trigger some kind of psychological reaction within me, because I started having these episodes of losing my grip on reality. I did that just 3 days ago. I've been slowly recovering since. The psychological response has been calming down too. Never in my life did I experience something so physically and mentally unbearable. Just thinking about it still makes me sick. Nice to know that it's just a temporary reaction, though. I did the same thing and took a 10mg pill to start and freaked out shortly after. I guess I'll just have the skip the meto for my plan which is going to suck..

Yes, I want the antiemetics for SN CTB.
I'm wary of taking a high dose of meto like the 3x10mg the standard protocols advise. It doesnt mix well with alcohol too apparently, and i dont mix well without alcohol lol.
Is that a medical emergency when that reaction happens? Did you just sit it out, or seek help?
Dont say if you'd rather not go into it, thats absolutely fine, and thanks your help.

I had an almost identical reaction and just tried to thug it out. Somehow managed to fall asleep and woke up feeling better. I still had residual effects for a few days though. I did think about calling the ambulance when it happened, though.

 

[Macedonian1987]

I was simply in an unbearable state. I can't describe it in words. It was worse than vomiting. I felt very bad, my whole body was twitching - my head, my arms, I was aching, I was bending over. It was like a very strong withdrawal. I bought the drug without a prescription. Never before have I experienced such terrible side effects from any pills

I read drug testimonials about metoclopramide, and i can confirm that this restlessness is frequent occurrence. It does indeed feels a bit like you are withdrawing from some medication. I felt something similar (to a lesser extent) when I did a test-drive of metoclopramide too.


One important thing for everyone reading this. Before CTB make sure you do a test drive with metoclopramide. Take 30mg of it on an empty stomach (if you never used this medication ever before). You don't want to have unwanted surprises on the day you CTB.