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I never did see that study. Maybe you can make a thread about it? I'm sure so many people are wondering.For anyone wondering about why acid reducers aren't recommended anymore, the acidic stomach environment will interact with nitrite to form nitric oxide and make you pass out faster. Also, an antacid won't affect the amount of nitrite absorbed per this study:
Increase in gastric pH reduces hypotensive effect of oral sodium nitrite in rats
The new pathway nitrate–nitrite–nitric oxide (NO) has emerged as a physiological alternative to the classical enzymatic pathway for NO formation from …www.sciencedirect.com
I know I was wondering for a while, but after a lot of research about the biochemistry of sodium nitrite ingestion, I learned that nitric oxide is a good thing and will help lower blood pressure and have a protective effect on the organs should the attempt fail. I might make a thread on it later
Yeah. It acts as a neuroprotectant also.
The other side of the coin is that, without hypotension, there will be no or less severe headache. This is something to consider when having no access to opioid painkillers (small doses of paracetamol or ibuprofen may be better than nothing, but not exactly a gold standard). Also, one symptom of low blood pressure in and of itself is nausea.
Yeah you can do with or without them, it's really up to the individual in the end. Also in the study I mentioned, omeprazole neither helped nor hurt the absorption of SN, it just affected hypotension.
