Help Potassium nitrite procedure

[ferrie]

Overdosing is far from my ideal method, but I came across lab grade potassium nitrite listed through a major retailer. I'm still undecided if this is an avenue I'll pursue because there's difficulties with receiving my mail without it being gone through & I prefer quicker methods. I am looking into more information about this though. I've attempted using the site search function, but most results just talk about SN or just don't seem very scientific. I did see that the calculated dose would be a 85:69 ratio with the lethal SN dose, though I would be interested to see if the mechanism of action due to the nitrite ion is the same & how symptoms compare between the two. Does anyone have knowledge about potassium nitrite besides assuming it's similar to SN?

 

[ferrie]

Bumping with more info

Potassium nitrite is a strong oxidizer with the chemical formula KNO2. High levels of potassium nitrite in the blood causes methemoglobinemia & its associated symptoms, headache, fatigue, dizziness, blue coloration to the skin & lips, due to the binding of the nitrite ion to blood cells, reducing their ability to carry oxygen. Sufficiently high levels can cause respiratory depression, collapse, and death. Potassium nitrite shares a method of action with sodium nitrite, but it takes more of the product to achieve the same effect. Its molar mass is approximately 85 g/mol. The molar mass of SN is approximately 69 g/mol. This is where the 85:69 dosing ratio comes from. However, LD 50 of potassium nitrite is cited at 235 mg/kg. Potassium nitrite is very soluble in water. At 0°C it's soluble at 281 g/100 mL, at 25°C at 312 g/100mL, and at 100°C at 413 g/100 mL. This is more soluble than sodium nitrite who at 25°C is 84.8 g/100 mL soluble. So while more potassium nitrite is required, less water is needed to dissolve it. It is also soluble in alcohol. Potassium nitrite is on the hazardous substance list because while not combustible itself, it may enhance combustion of other substances. It is non-flammable but explodes at 537°C. Overall, it is less ideal than its counterpart sodium nitrite, but in some locations it may be easier to source. I personally am still able to find it through a major online retailer. Less water is needed, which is nice. However, it would require more product, and your body rejects them mixture due to the amount of salt required. An equivalent dose of potassium nitrite to 25 g of SN would be about 31g. An extra 6g of salt may seem insignificant, but I feel it would probably increase the chances of vomiting even with an AE. I have access to online medical journals & make look into more research about it. It seems like an alternative for SN that would have more issues with keeping it down, but I figured the math on it might be interesting

 

[AmericanMary]

I looked into this for a while and couldn't find many answers. Commenting to find this post later.

 

[itsalittlecold]

Hi sorry this is a unrelated question, I saw on
Your other post you was/is a medical student and you have great passion for it.
Could I ask what you know of methylene blue? I know it's full of very good health benefits. However it seems if dosed higher it has the opposite effects. Since it's a treatment for sn poisoning, it helps the blood bind oxygen again… but from what I've read, if dosed higher wouldn't that stop our blood binding oxygen, just as sn/kn would?

Once again I apologise, I'm just a deep thinker and the ease of access for methylene blue has me very intrigued & if it could work the way I think, I doubt they'd be an antidote

 

[ferrie]

Hi sorry this is a unrelated question, I saw on
Your other post you was/is a medical student and you have great passion for it.
Could I ask what you know of methylene blue? I know it's full of very good health benefits. However it seems if dosed higher it has the opposite effects. Since it's a treatment for sn poisoning, it helps the blood bind oxygen again… but from what I've read, if dosed higher wouldn't that stop our blood binding oxygen, just as sn/kn would?

Once again I apologise, I'm just a deep thinker and the ease of access for methylene blue has me very intrigued & if it could work the way I think, I doubt they'd be an antidote

I don't know of any cases where methylene blue poisoning was toxic. Methylene blue in too high of a dose actually causes methemoglobinemia since it also binds to hemoglobin but not in a manner that seems sufficient to CTB. It also needs to be administered IV, so most people can't give it to themselves. It can also cause localized necrosis

 

[itsalittlecold]

I don't know of any cases where methylene blue poisoning was toxic. Methylene blue in too high of a dose actually causes methemoglobinemia since it also binds to hemoglobin but not in a manner that seems sufficient to CTB. It also needs to be administered IV, so most people can't give it to themselves. It can also cause localized necrosis

Thank you for that! It makes perfect sense to me. The only cases I saw of fatality were due to serotonin syndrome- combined with anti-depressants.

There's 1% solution that can be bought and mixed with water orally. However I imagine the quantity needed would be insane. Thank you