Opioid Megathread & Overview

[hiitsme]

i'm going to boof 3g of ODSMT mixed with a high dose of benzos in the next few days hopefully guess I'll update if I survive lol

 

[wham311]

i'm going to boof 3g of ODSMT mixed with a high dose of benzos in the next few days hopefully guess I'll update if I survive lol

Please do

 

[Caribbean Sky]

Hi, when doing research I found that the soluability (how much can be dissolved) of heroin in saline is very low - so low that you would not be able to inject enough in a single syringe (if you oversaturated it you would be injecting solid powder which could mess up your method)

I'm not sure if this information is true or false, so please help me determine that, but if true, what do you recommend dissolving heroin powder/crystals in to ensure a lethal dose can be dissolved?

 

[Romanticize]

Hi, when doing research I found that the soluability (how much can be dissolved) of heroin in saline is very low - so low that you would not be able to inject enough in a single syringe (if you oversaturated it you would be injecting solid powder which could mess up your method)

I'm not sure if this information is true or false, so please help me determine that, but if true, what do you recommend dissolving heroin powder/crystals in to ensure a lethal dose can be dissolved?

Heroin HCl [crystals, powder] dissolves well enough in heated water [like morphine]. Just crush it into fine powder, if it's not already in this state, mix with few mls of water [depends on how big your syringe is, for morphine I used 5-20mls], place it over a source of fire, and stir it gently. Afterwards place syringe [without needle] on a filter, and just suck the solution into it - but I guess you know it.

Only base heroin [meant for smoking] does not dissolve in water well, it needs some kind of acid.

 

[Rhizomorph1]

Hi, when doing research I found that the soluability (how much can be dissolved) of heroin in saline is very low - so low that you would not be able to inject enough in a single syringe (if you oversaturated it you would be injecting solid powder which could mess up your method)

I'm not sure if this information is true or false, so please help me determine that, but if true, what do you recommend dissolving heroin powder/crystals in to ensure a lethal dose can be dissolved?

It's true. Ascorbic acid can help dissolve it but there will still be a ceiling to how much can be dissolved. Assistance from another person to ensure a large volume of liquid with opioids dissolved in it would probably be the only way to negate this so you absorbed it all before losing consciousness.

 

[Ariel1]

Just wondering why certain prescription opioid make you feel different. When I take dilaudid (hydromorphone) it does nothing for me except make me itchy. Doesn't even really help with pain that much. But I once took percocets and I felt great. Not sure why.

 

[Caribbean Sky]

It's true. Ascorbic acid can help dissolve it but there will still be a ceiling to how much can be dissolved. Assistance from another person to ensure a large volume of liquid with opioids dissolved in it would probably be the only way to negate this so you absorbed it all before losing consciousness.

"Assistance from another person" in terms of making sure it's all dissolved, or a assisted suicide? If it's the latter, finding a person to do that for you was very very hard. Surely there's another way to make sure you get it all, or at least be a mountain injected is a fatal dose...

edit: how much does the solubility of heroin increase with ascorbic acid? in mg/ml. like an increase from, random nonfactual number, ~1.5mg/ml to 50/mg ml.
and this is different from my previous question, asking if there was more than one way to make sure you "got it all": is ascorbic acid the only way to increase the solubility? What about the method I sent you in your dms of using various food grade liquids? Probably stupid but I thought I would ask.

 

[Romanticize]

Just wondering why certain prescription opioid make you feel different. When I take dilaudid (hydromorphone) it does nothing for me except make me itchy. Doesn't even really help with pain that much. But I once took percocets and I felt great. Not sure why.

They have different binding affinity for different opioid receptors: μ (mu), δ (delta) & κ (kappa).
Also, there are differences from a person to person.
My friend didn't feel anything on morphine, while oxy gave him energy and euphoria. So you see, some people got paradoxical reaction (like energy instead of sleepiness, relaxation) or no effect at all. Dilaudid is one of the most euphoric ones, but if oxy works, you have nothing to worry about.

 

[Rhizomorph1]

"Assistance from another person" in terms of making sure it's all dissolved, or a assisted suicide? If it's the latter, finding a person to do that for you was very very hard. Surely there's another way to make sure you get it all, or at least be a mountain injected is a fatal dose...

edit: how much does the solubility of heroin increase with ascorbic acid? in mg/ml. like an increase from, random nonfactual number, ~1.5mg/ml to 50/mg ml.
and this is different from my previous question, asking if there was more than one way to make sure you "got it all": is ascorbic acid the only way to increase the solubility? What about the method I sent you in your dms of using various food grade liquids? Probably stupid but I thought I would ask.

Assisted dying would be the only way to negate the risk of losing consciousness before absorption. Yes, this is what I am saying.

I don't know any figures re: the solubility with ascorbic acid unfortunately.

They have different binding affinity for different opioid receptors: μ (mu), δ (delta) & κ (kappa).
Also, there are differences from a person to person.
My friend didn't feel anything on morphine, while oxy gave him energy and euphoria. So you see, some people got paradoxical reaction (like energy instead of sleepiness, relaxation) or no effect at all. Dilaudid is one of the most euphoric ones, but if oxy works, you have nothing to worry about.

This!

Some opioids like tramadol even have binding activity with serotonin (5-HT).

So even though opioid receptors are all being hit, there are different concentrations and rates they are binding in different parts of the brain.

Typically the Mu opioid receptor is primarily responsible for the euphoria and painkilling effects.

The kappa opioid receptor has some analgesic (pain killing) effect but also a sedating effect, so less sedating opioids often don't have as high of affinity for it. (Affinity can be described as the kinetic "pull" a drug/ligand has for the receptor; like a lock and key - some drugs have more energetic pull towards certain receptors or will stay attached to those receptors for longer periods)

Also, drugs like oxy pass through the blood brain barrier much faster due to higher lipid solubility, causing greater concentration, which can play a role in potency or effect intensity.

 

[Caribbean Sky]

Assisted dying would be the only way to negate the risk of losing consciousness before absorption. Yes, this is what I am saying.

I don't know any figures re: the solubility with ascorbic acid unfortunately.

This!

Some opioids like tramadol even have binding activity with serotonin (5-HT).

So even though opioid receptors are all being hit, there are different concentrations and rates they are binding in different parts of the brain.

Typically the Mu opioid receptor is primarily responsible for the euphoria and painkilling effects.

The kappa opioid receptor has some analgesic (pain killing) effect but also a sedating effect, so less sedating opioids often don't have as high of affinity for it. (Affinity can be described as the kinetic "pull" a drug/ligand has for the receptor; like a lock and key - some drugs have more energetic pull towards certain receptors or will stay attached to those receptors for longer periods)

Also, drugs like oxy pass through the blood brain barrier much faster due to higher lipid solubility, causing greater concentration, which can play a role in potency or effect intensity.

So the risk of losing consciousness before absorption seems to be not associated so much with the solubility of the opioid; that is solved with the ascorbic acid in the filter, yes?
But the "risk of losing consciousness before full absorption" is a unique risk in and of itself....

Rhizo, I gotta be honest, I'm so confused. Why isn't this stuff in your OP? Why isn't
1. using ascorbic acid with a cotton filter to increase solubility.
2. needing assisted suicide to completely avoid the risk of not full absorption before unconsciousness

This stuff in your OP?

OK, um... at the very least, can increasing the soluability with the ascorbic acid and cotton filter at least greatly lower the risk of unconsciousness before full absorption?
Because there will be less in the syringe?
Assign from directly injecting into your vein, is there a way to make sure that all of the stuff gets in your veins after you pass out quickly enough?

about what the other user said.. about the bonding affinities. You would still recommend heroin/fentanyl as the ctb drug correct?

Assisted dying would be the only way to negate the risk of losing consciousness before absorption. Yes, this is what I am saying.

I don't know any figures re: the solubility with ascorbic acid unfortunately.

This!

Some opioids like tramadol even have binding activity with serotonin (5-HT).

So even though opioid receptors are all being hit, there are different concentrations and rates they are binding in different parts of the brain.

Typically the Mu opioid receptor is primarily responsible for the euphoria and painkilling effects.

The kappa opioid receptor has some analgesic (pain killing) effect but also a sedating effect, so less sedating opioids often don't have as high of affinity for it. (Affinity can be described as the kinetic "pull" a drug/ligand has for the receptor; like a lock and key - some drugs have more energetic pull towards certain receptors or will stay attached to those receptors for longer periods)

Also, drugs like oxy pass through the blood brain barrier much faster due to higher lipid solubility, causing greater concentration, which can play a role in potency or effect intensity.

Like, a lot of things with a lot of CBT methods are risks that are never going to be feeling negated. I understand that without assisted dying that risk will not be falling, negated, like a few other risks with this method. But increasing the solubility at least heavily lowers that risk right?
But then, what do you recommend rectal administration over IV for opioid overdose then? Seems easier, there's no risk of not getting full absorption before unconsciousness... this question I'd be especially interested to hear the answer from you about.

assisted dying.. I think there's a form for it on SaSu, but I can't imagine how much time it would take to get that set up. I'll do whatever I can to avoid that, thanks.
hmm.. I had one more question what was it..oh! where can I find a guide on the ascorbic acid with cotton filter trick? Where can I get ascorbic acid and the type of cotton filters I need? Thanks!

p.s. reason I'm especially interested in the answer if you would recommend rectal administration IV is obviously because it would be much simpler.. doesn't seem to be a need for a ascorbic acid/cotton filter, or assisted suicide.. but of course, if I'm wrong, correct me. but if I'm right, you can absolutely see why I would prefer rectal administration.

also, if I'm right, you should definitely put that in your OP; I know you probably won't, because you want to dissuade people from this method – but a lot of people would be relieved to hear that rectal administration is just as effective as IV administration, but simpler and easier.
admittedly, (with rectal administration) without needing to account for even more complications, people would fail a lot less and succeed a lot more.

 

[hiitsme]

Please do

the package is here today

 

[Violet7]

Thank you for taking the time to share your knowledge. I wish years of psychiatric torture hadn't caused irreparable brain damage. I could have provided knowledge. I feel useless now. Old tired and useless. U have a kind soul. Please don't depart before letting me know u r ready to CTB. I've become quite fond of u and that heart of gold. I don't know what has brought u here but I am sorry. The world needs more people like you. I will always remember u were kind to me for no other reason than u just were. I haven't had that experience often.

I have also been harmed by psychiatric torture and the medication I have taken has made me brain damaged and so sick. I have akathesia so badly from Benzo and remeron turning on me. Bless you

 

[wham311]

How

the package is here today

How goes it

 

[HD72]

I have also been harmed by psychiatric torture and the medication I have taken has made me brain damaged and so sick. I have akathesia so badly from Benzo and remeron turning on me. Bless you

I'm on the same meds. I don't believe anyone or anything is going to bless us. We are the forgotten.

 

[Rhizomorph1]

So the risk of losing consciousness before absorption seems to be not associated so much with the solubility of the opioid; that is solved with the ascorbic acid in the filter, yes?
But the "risk of losing consciousness before full absorption" is a unique risk in and of itself....

Rhizo, I gotta be honest, I'm so confused. Why isn't this stuff in your OP? Why isn't
1. using ascorbic acid with a cotton filter to increase solubility.
2. needing assisted suicide to completely avoid the risk of not full absorption before unconsciousness

This stuff in your OP?

OK, um... at the very least, can increasing the soluability with the ascorbic acid and cotton filter at least greatly lower the risk of unconsciousness before full absorption?
Because there will be less in the syringe?
Assign from directly injecting into your vein, is there a way to make sure that all of the stuff gets in your veins after you pass out quickly enough?

about what the other user said.. about the bonding affinities. You would still recommend heroin/fentanyl as the ctb drug correct?


Like, a lot of things with a lot of CBT methods are risks that are never going to be feeling negated. I understand that without assisted dying that risk will not be falling, negated, like a few other risks with this method. But increasing the solubility at least heavily lowers that risk right?
But then, what do you recommend rectal administration over IV for opioid overdose then? Seems easier, there's no risk of not getting full absorption before unconsciousness... this question I'd be especially interested to hear the answer from you about.

assisted dying.. I think there's a form for it on SaSu, but I can't imagine how much time it would take to get that set up. I'll do whatever I can to avoid that, thanks.
hmm.. I had one more question what was it..oh! where can I find a guide on the ascorbic acid with cotton filter trick? Where can I get ascorbic acid and the type of cotton filters I need? Thanks!

p.s. reason I'm especially interested in the answer if you would recommend rectal administration IV is obviously because it would be much simpler.. doesn't seem to be a need for a ascorbic acid/cotton filter, or assisted suicide.. but of course, if I'm wrong, correct me. but if I'm right, you can absolutely see why I would prefer rectal administration.

also, if I'm right, you should definitely put that in your OP; I know you probably won't, because you want to dissuade people from this method – but a lot of people would be relieved to hear that rectal administration is just as effective as IV administration, but simpler and easier.
admittedly, (with rectal administration) without needing to account for even more complications, people would fail a lot less and succeed a lot more.

Solved is not the right language, only reduced. Risk is quantitative, not categorical. Due to the plethora of risks involved with this method at multiple points along the ROA, pharmacodynamics (sites of action), metabolism, drug purity, etc. adding the ascorbic acid alone will only marginally increase the reliability. The reliability will still be – approximately – in the moderate zone, however.

I am also not a medical or accreddited professional/voice on the topic. I am not paid for my labour thus why the OP doesn't go into specifics around the solubility or kinetics of specific ROAs. A doctor/researcher would need to write a manuscript of hundred pages or more to cover all that; one can only do their best given the unforgivably restricted nature of MAID accessibility in many jurisdictions that have resulted in this "best case scenario/freedom of information" post. In an ideal world, we would have teams of paid professionals working on authorized routes of care + MAID, but as of now, some of this information remains limited. Please understand I do my best but I do not take responsibility for your means of information; I would need to be accredited and paid for that in a legal jurisdiction

If you live somewhere where MAID is available, I highly encourage that route. Or the swiss option if you can travel.

I'm sorry but I don't have the time for much more thorough correspondence beyond just stating that there is *no* practical way to get this method to become as reliable as you seem to wish. It is, at best, moderate. But I do wish you well

 

[Caribbean Sky]

Solved is not the right language, only reduced. Risk is quantitative, not categorical. Due to the plethora of risks involved with this method at multiple points along the ROA, pharmacodynamics (sites of action), metabolism, drug purity, etc. adding the ascorbic acid alone will only marginally increase the reliability. The reliability will still be – approximately – in the moderate zone, however.

I am also not a medical or accreddited professional/voice on the topic. I am not paid for my labour thus why the OP doesn't go into specifics around the solubility or kinetics of specific ROAs. A doctor/researcher would need to write a manuscript of hundred pages or more to cover all that; one can only do their best given the unforgivably restricted nature of MAID accessibility in many jurisdictions that have resulted in this "best case scenario/freedom of information" post. In an ideal world, we would have teams of paid professionals working on authorized routes of care + MAID, but as of now, some of this information remains limited. Please understand I do my best but I do not take responsibility for your means of information; I would need to be accredited and paid for that in a legal jurisdiction

If you live somewhere where MAID is available, I highly encourage that route. Or the swiss option if you can travel.

I'm sorry but I don't have the time for much more thorough correspondence beyond just stating that there is *no* practical way to get this method to become as reliable as you seem to wish. It is, at best, moderate. But I do wish you well

no shit.

Sorry, that's not meant to be offensive - when I said "solved" I meant interchangeably.

no ctb method is ever fully without risk and people are gonna drive themselves crazy if they try to account for every risk.

OK; I understand is the term "recommendation" is not a comfortable term to use, so then I'll restate this from my perspective: (and this is really the last question I have for you since you seem to be concerned about ongoing conversation)
if you feel you cannot appropriately answer this question that's fine, let me know, but to me, because you're able to say in the OP that you should either choose IV or rectal administration, that you may be able to answer.

it seems like – to me – rectal administration is better, because you do not have to worry about the risks associated with dissolving powder in liquid to inject yourself, or with solubility - of course this doesn't matter if you are injecting liquid into your ass. I'm not sure if you're saying rectal administration can be completed with powder or it has to be liquid. Establishing that is the key to the answer to this question.

I still have confidence in myself and my research so I'm not worried either way, but if you can apply rectally with just powder, you save yourself a lot of stress and suffering and minimize your risk by eliminating another factor.
If this is true, would recommend the administration not be the better way to go?
what is your profession, Rhizo, I wonder. You say you are not a professional; but of course, there is a precedent reason to believe your advice on opiate over anyone else.

That's all I have to ask you for now. I won't say anything else for the sake of not making my reply here more confusing.

 

[Life'sA6itch]

I was wondering if vaginal application would be as effective? I have some I never took after an emergency surgery.

 

[Rhizomorph1]

no shit.

Sorry, that's not meant to be offensive - when I said "solved" I meant interchangeably.

no ctb method is ever fully without risk and people are gonna drive themselves crazy if they try to account for every risk.

OK; I understand is the term "recommendation" is not a comfortable term to use, so then I'll restate this from my perspective: (and this is really the last question I have for you since you seem to be concerned about ongoing conversation)
if you feel you cannot appropriately answer this question that's fine, let me know, but to me, because you're able to say in the OP that you should either choose IV or rectal administration, that you may be able to answer.

it seems like – to me – rectal administration is better, because you do not have to worry about the risks associated with dissolving powder in liquid to inject yourself, or with solubility - of course this doesn't matter if you are injecting liquid into your ass. I'm not sure if you're saying rectal administration can be completed with powder or it has to be liquid. Establishing that is the key to the answer to this question.

I still have confidence in myself and my research so I'm not worried either way, but if you can apply rectally with just powder, you save yourself a lot of stress and suffering and minimize your risk by eliminating another factor.
If this is true, would recommend the administration not be the better way to go?
what is your profession, Rhizo, I wonder. You say you are not a professional; but of course, there is a precedent reason to believe your advice on opiate over anyone else.

That's all I have to ask you for now. I won't say anything else for the sake of not making my reply here more confusing.

Rectal administration will reduce (key word reduce) the issues we discussed with IV use re passing out too quickly or excipients (other matter that isn't the active drug) lodging or preventing absorption. You will still require a large enough syringe to fully dissolve the amount, but administering it will be easier. Dissolved in liquid is ideal as solid particles will be challenging to deposit and will stick to the outer rectal lining or likely get lost on whatever instrument you use to deposit it. 2-3cm inside the rectum using an oral syringe so that it is deposited on the internal anal sphincter where there is maximal absorption. Clearing the anus of feces prior and waiting some time is good practice as feces themselves can absorb the drug. The risk of losing consciousness before depositing the entire syringe will be less as absorption is slower. This incurs other risks due to a flattened absorption curve (less peak activity = increased respiration during the drug effects, longer duration). Risks unrelated to ROA will still remain. If you should happen to wish to adopt the inherent risks, I would recommend rectal administration over IV if you are comfortable with it and read a bit on how to do it properly.

I am unemployed, due to chronic illness and processing a MAID application, but my previous job was working as a research technician in the areas of psychedelic medicine (exploring patient-doctor education, access, drug use patterns, reasons for use), healthcare access, healthcare team culture and optimization, and the toxic drug crisis (opioid overdoses, research on harm reduction, opioid agonist therapy, drug testing with spectrometers, coroners data, etc.). I have a BA in psychology with honours and specialized in psychopharmacology, psychedelic medicine, and substance abuse.

A B.A. gives me specialized knowledge to speak on the subject with extra confidence and training but I would need a medical degree or to be part of a pharmacology lab tasked with this specific area and approved by colleges to represent medicine. I am simply an informed student/fellow forum member who wishes to voluntarily die.

I hope this represents myself directly and transparently :)

 

[Caribbean Sky]

Rectal administration will reduce (key word reduce) the issues we discussed with IV use re passing out too quickly or excipients (other matter that isn't the active drug) lodging or preventing absorption. You will still require a large enough syringe to fully dissolve the amount, but administering it will be easier. Dissolved in liquid is ideal as solid particles will be challenging to deposit and will stick to the outer rectal lining or likely get lost on whatever instrument you use to deposit it. 2-3cm inside the rectum using an oral syringe so that it is deposited on the internal anal sphincter where there is maximal absorption. Clearing the anus of feces prior and waiting some time is good practice as feces themselves can absorb the drug. The risk of losing consciousness before depositing the entire syringe will be less as absorption is slower. This incurs other risks due to a flattened absorption curve (less peak activity = increased respiration during the drug effects, longer duration). Risks unrelated to ROA will still remain. If you should happen to wish to adopt the inherent risks, I would recommend rectal administration over IV if you are comfortable with it and read a bit on how to do it properly.

I am unemployed, due to chronic illness and processing a MAID application, but my previous job was working as a research technician in the areas of psychedelic medicine (exploring patient-doctor education, access, drug use patterns, reasons for use), healthcare access, healthcare team culture and optimization, and the toxic drug crisis (opioid overdoses, research on harm reduction, opioid agonist therapy, drug testing with spectrometers, coroners data, etc.). I have a BA in psychology with honours and specialized in psychopharmacology, psychedelic medicine, and substance abuse.

A B.A. gives me specialized knowledge to speak on the subject with extra confidence and training but I would need a medical degree or to be part of a pharmacology lab tasked with this specific area and approved by colleges to represent medicine. I am simply an informed student/fellow forum member who wishes to voluntarily die.

I hope this represents myself directly and transparently :)

it does, thanks!

I do believe that's all of my questions for you. Thanks!

MAID..good for you! I also have a chronic illness. No one can seem to diagnose it though.
If you can't answer, hearing about your experience so far with MAID would be very helpful for me as a sufferer of a chronic illness as well.
This chronic illness is not my entire reason for wishing to voluntarily die, but I have documentation from my doctor saying that this illness would probably severely limit me from doing any sort of activity at all, other than resting in a bed.

I understand it is a Canadian service, but I'm wondering if they serve international residence, such as people in the USA like me.

thanks again, and your transparency is appreciated!

 

[wham311]

4.7 precent of all deaths in Canada last year.

Like this world fucking sucks dude, you know that number would be higher if more people had access or balls

 

[Rhizomorph1]

it does, thanks!

I do believe that's all of my questions for you. Thanks!

MAID..good for you! I also have a chronic illness. No one can seem to diagnose it though.
If you can't answer, hearing about your experience so far with MAID would be very helpful for me as a sufferer of a chronic illness as well.
This chronic illness is not my entire reason for wishing to voluntarily die, but I have documentation from my doctor saying that this illness would probably severely limit me from doing any sort of activity at all, other than resting in a bed.

I understand it is a Canadian service, but I'm wondering if they serve international residence, such as people in the USA like me.

thanks again, and your transparency is appreciated!

I'm glad it's been helpful

Chronic illness is awful and I hope you get some more direction/answers from your physician.

Canada doesn't offer MAID to non-Canadians but I know Switzerland does. If you can acquire appropriate documentation from your doctors I highly recommend the swiss option. Pegasos, dignitas, or exit all offer suitable care and will make sure you are comfortable. The risk will be virtually null so you don't have to worry about pain, injury, or failure.

The downside is you will have to navigate diagnosis and medical self advocacy. Although Switzerland has independent doctors who can assess your eligibility for MAID, you will need a doctor where you live to provide the diagnosis & paperwork stating the nature of your condition.

Personally, I highly vouch for this route. Bureaucracy sucks but it will pay off in the long run. My experience thus far navigating it has been such. It's long and arduous, but compared to a lifetime of pain, I'd rather go out with transparency, dignity, and some level of support from family and friends; even if navigating the relationship with family and friends has been tumultuous or judgmental at times.

Care to elaborate on the nature & symptoms of the illness you suspect you have? It can be hard to categorize without diagnosis, but I'm just curious what your subjective experience of it is?

-R

 

[Caribbean Sky]

I'm glad it's been helpful

Chronic illness is awful and I hope you get some more direction/answers from your physician.

Canada doesn't offer MAID to non-Canadians but I know Switzerland does. If you can acquire appropriate documentation from your doctors I highly recommend the swiss option. Pegasos, dignitas, or exit all offer suitable care and will make sure you are comfortable. The risk will be virtually null so you don't have to worry about pain, injury, or failure.

The downside is you will have to navigate diagnosis and medical self advocacy. Although Switzerland has independent doctors who can assess your eligibility for MAID, you will need a doctor where you live to provide the diagnosis & paperwork stating the nature of your condition.

Personally, I highly vouch for this route. Bureaucracy sucks but it will pay off in the long run. My experience thus far navigating it has been such. It's long and arduous, but compared to a lifetime of pain, I'd rather go out with transparency, dignity, and some level of support from family and friends; even if navigating the relationship with family and friends has been tumultuous or judgmental at times.

Care to elaborate on the nature & symptoms of the illness you suspect you have? It can be hard to categorize without diagnosis, but I'm just curious what your subjective experience of it is?

-R

well, I've been sick since late 2023, since October 2023 to be exact.
It started with mysterious fevers that couldn't be explained by any test result, and I constantly felt like I had a fever. I had a fever for months, which greatly affected my body during this time. No doctor could diagnose, somewhere disrespectful, it wasn't rheumatological, cause no information, no infectious disease, as far as I know, cancer was ruled out, neurological disorders, etc.

But symptoms include intense, deep, aching pain throughout my entire body – it's horrible. I think it's one of the worst pain someone can be in constantly. I've had to dissociate just to not lose my mind. I can't work, I can't move very much, I can't exercise.
i've become constantly pale, sick, and sweaty. Other things that come and go include trouble, breathing, tightness of lungs, heart, palpitations, and so much more that I have written down that it is just way too much to share and would take way too long to gather.

One of the big notable features is neurological symptoms. Stiffness, trouble, ambulating, dizziness, twitching, temporary, facial paralysis, numbness, eyes twitching, and extreme sensitivity to light.

I have no idea why no doctor can diagnose me. They all tell me my results and all my scans not me as a perfectly healthy person. The only thing of note recently is a prolactinoma, on my pituitary system, but there was a full pituitary workup done, and the only high result with prolactin apparently. I have no idea what's going on.

 

[panda55]

I would love to go with this method cause it sounds peaceful and also getting high before you die doesn't sound too bad either. But like I said in another thread if you are leaving a life insurance policy just make sure to read your terms of service as a lot of them won't payout if you use illegal drugs. I can't afford to risk that for my family.

 

[chris.watt]

35 yo, male. 65kg, 165cm. Healthy (gym, boxing). Opioid naive, don't drink, don't smoke, don't take drugs or prescription meds. UK.

Method:

1. Isolated in the apartment (4-5days). No intervention of any kind (medical, relatives, friends etc).
2. Alcohol + opioids overdose:
   1. Alcohol. 200-300ml of vodka.
   2. Opioids:
      1. Administered via IV. Assuming I learn how to IV using IV fluids.
      2. Street opioids available in the UK - so heroine, methadone, fentanyl if I'm really lucky to find it here. Can't rely on traces of fentanyl as it is not US.
      3. Dosage. Hardest part. Assuming 15% purity. So using 1g of street herion should yield 150mg of 'pure' heroin. Assuming I will learn how to cook it.
3. Drink vodka —> administer heroin —> pass out --> suffocate and die.

In terms of success / lethality - how effective and reliable is this plan?
What am I missing or what aspects I am not aware of / not taking into account?

 

[yyytry]

Rectal administration will reduce (key word reduce) the issues we discussed with IV use re passing out too quickly or excipients (other matter that isn't the active drug) lodging or preventing absorption. You will still require a large enough syringe to fully dissolve the amount, but administering it will be easier. Dissolved in liquid is ideal as solid particles will be challenging to deposit and will stick to the outer rectal lining or likely get lost on whatever instrument you use to deposit it. 2-3cm inside the rectum using an oral syringe so that it is deposited on the internal anal sphincter where there is maximal absorption. Clearing the anus of feces prior and waiting some time is good practice as feces themselves can absorb the drug. The risk of losing consciousness before depositing the entire syringe will be less as absorption is slower. This incurs other risks due to a flattened absorption curve (less peak activity = increased respiration during the drug effects, longer duration). Risks unrelated to ROA will still remain. If you should happen to wish to adopt the inherent risks, I would recommend rectal administration over IV if you are comfortable with it and read a bit on how to do it properly.

I am unemployed, due to chronic illness and processing a MAID application, but my previous job was working as a research technician in the areas of psychedelic medicine (exploring patient-doctor education, access, drug use patterns, reasons for use), healthcare access, healthcare team culture and optimization, and the toxic drug crisis (opioid overdoses, research on harm reduction, opioid agonist therapy, drug testing with spectrometers, coroners data, etc.). I have a BA in psychology with honours and specialized in psychopharmacology, psychedelic medicine, and substance abuse.

A B.A. gives me specialized knowledge to speak on the subject with extra confidence and training but I would need a medical degree or to be part of a pharmacology lab tasked with this specific area and approved by colleges to represent medicine. I am simply an informed student/fellow forum member who wishes to voluntarily die.

I hope this represents myself directly and transparently :)

What liquid would you recommend for dissolving the oxy powder?
Saline, like what's in the fleet enemas (the nozzle bottle format is easy to use)…
or distilled water?

Have been considering emptying the fleet bottle and refilling with the mixture.