
littlelady774
running on empty
- Dec 20, 2018
- 708
A lot of people have been wondering lately if there can be any organ damage if you fail SN. And rightfully so,- anything that inhibits oxygen delivery to the tissues can definitely cause some damage.
There are a few organs that are most dependent on oxygen : the heart, brain and liver. You would think these organs would be affected the most from methemoglobinemia. But this seems to not be the case!
I was reading this article about anemic hypoxia and what organs it affects the most. It says the kidneys because blood supply isn't increased there like the brain and heart. Unlike the exit bag or hanging, vasodilation is a compensatory mechanism involved in hypoxic blood disorders such as anemia and methemoglobinemia. It makes sure the brain and heart are still getting enough oxygen. This vasodilation does not occur for the kidneys though.
Note this is only for sub acute hypoxia.
Once the methemoglobinemia has progressed to severe, cells start dying via apoptosis. But you're pretty much already on death's door by this point anyway. Levels around 50-70%. Just make sure you don't get "rescued" at this point !
Article I was reading: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966813/#!po=40.4930
TLDR;
You're more likely to get kidney/renal injury from a failed SN attempt than a brain injury. It's a slow process because of the body's compensatory mechanism of vasodilation.
There are a few organs that are most dependent on oxygen : the heart, brain and liver. You would think these organs would be affected the most from methemoglobinemia. But this seems to not be the case!
I was reading this article about anemic hypoxia and what organs it affects the most. It says the kidneys because blood supply isn't increased there like the brain and heart. Unlike the exit bag or hanging, vasodilation is a compensatory mechanism involved in hypoxic blood disorders such as anemia and methemoglobinemia. It makes sure the brain and heart are still getting enough oxygen. This vasodilation does not occur for the kidneys though.
Note this is only for sub acute hypoxia.
Once the methemoglobinemia has progressed to severe, cells start dying via apoptosis. But you're pretty much already on death's door by this point anyway. Levels around 50-70%. Just make sure you don't get "rescued" at this point !
Article I was reading: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966813/#!po=40.4930
TLDR;
You're more likely to get kidney/renal injury from a failed SN attempt than a brain injury. It's a slow process because of the body's compensatory mechanism of vasodilation.
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