Yes, 1 bottle is enough to kill you. The PPHE states that 1 bottle of Pentobarbital is enough to kill a human being in 15-30 minutes. But i depends. Every human being is different, every human body reacts differently and not all have the same reaction to Pentobarbital. The Lethal Dosis of Pentobarbital is between 2-10G, 1 Bottle = 100ML, 6.2 G if I am correct and not mistaken. But when you want to make Pentobarbital work faster, drink it with a little alcohol. That will help to make it more lethal.