All the ibuprofen in the world isn't going to help you if you get something serious like cancer or something like that. My sister had liver cancer and was on quite a few different drugs for the pain, including opioids and lidocaine patches, and she still had considerable pain on a consistent basis, until she finally reached Hospice care and they were able to give her even more powerful drugs to render her unconscious. What I would do, though, if I get something really serious, is take myself out almost immediately upon learning of it, or suspecting it. I mean I'm going to go anyway, so I'd just have to move things up and forget about the things I'm doing. Infections can cause a lot of pain, too, far beyond what any ibuprofen is going to knock down, at least once the infection becomes systemic.