Help Epinephrine/Adrenaline IV infusion

[Valky]

So the max dose is between 3-4mg or 7-8mg.

Sadly, there is only one reported case of a woman's suicide by injecting two EpiPens.

I just wanted to ask if anyone has any other information on the necessary lethal dose when it comes to IV injections.

 

[Aisley]

Seems 62mg/kg epi to 11mg/kg for adrenaline, for LD's. Don't know why that is, they're the same thing? But surely this would be as harrowing of a way to go as a coke od?

 

[Valky]

Seems 62mg/kg epi to 11mg/kg for adrenaline, for LD's. Don't know why that is, they're the same thing? But surely this would be as harrowing of a way to go as a coke od?

May I ask where you got those numbers from?

 

[willitpass]

Epinephrine causes your blood vessels to dilate, you will become incredibly tachycardic and hypertensive. I don't have a time frame on how long it will take to kill you but you will most likely die from a stroke caused by the hypertension. It will not feel pleasant. And because adrenaline (which is what epinephrine is) is a fight or flight hormone, you will probably feel the worst sense of impending doom you have ever had. I don't think this would be a pleasant way to die.

Epipens are also IM injections as opposed to IV infusions. I don't think you would be able to find epinephrine in an infusion form, which would complicate things further because you would have to stab yourself with multiple epipens as you become increasingly shakey and unwell.

 

[downndone2]

Miserable exit

 

[Aisley]

May I ask where you got those numbers from?

Adrenaline toxicity in mice: sensitization of alpha 1 adrenoreceptors by nitroglycerin - PubMed

In mice, injected subcutaneously with nitroglycerin (GTN) for 12 days, adrenaline exhibited an increased toxicity. The LD50 value for adrenaline in control animals was 11.1 mg/kg b.wt. In GTN-treated animals the LD50 value for adrenaline, measured 3 days after the last injection of GTN, was 9.1...

pubmed.ncbi.nlm.nih.gov

Epinephrine

Epinephrine | C9H13NO3 | CID 5816 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

pubchem.ncbi.nlm.nih.gov

 

[Valky]

Epinephrine causes your blood vessels to dilate, you will become incredibly tachycardic and hypertensive. I don't have a time frame on how long it will take to kill you but you will most likely die from a stroke caused by the hypertension. It will not feel pleasant. And because adrenaline (which is what epinephrine is) is a fight or flight hormone, you will probably feel the worst sense of impending doom you have ever had. I don't think this would be a pleasant way to die.

Epipens are also IM injections as opposed to IV infusions. I don't think you would be able to find epinephrine in an infusion form, which would complicate things further because you would have to stab yourself with multiple epipens as you become increasingly shakey and unwell.

I am very well aware of all that.

I have epinephrin in infusion form or I would not be asking but thanks for the information.

Miserable exit

Not my question but thanks

Adrenaline toxicity in mice: sensitization of alpha 1 adrenoreceptors by nitroglycerin - PubMed

In mice, injected subcutaneously with nitroglycerin (GTN) for 12 days, adrenaline exhibited an increased toxicity. The LD50 value for adrenaline in control animals was 11.1 mg/kg b.wt. In GTN-treated animals the LD50 value for adrenaline, measured 3 days after the last injection of GTN, was 9.1...

pubmed.ncbi.nlm.nih.gov

Epinephrine

Epinephrine | C9H13NO3 | CID 5816 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

pubchem.ncbi.nlm.nih.gov

Sadly not answering the question about IV injections but the first one is still of help, thank you!