Sure, but how do you know they won't fail or will be entirely peaceful?
If we consider drowning for example, there are a lot of evidences that a hypoxia with a non-high CO2 level does not cause sufferings and you can make drowning nearly as peaceful as dying with exit bag using an inert gas. The basic variant of the method is well known here as SWB, the advanced variant implies the usage of an asphyxiant gas, like with the exit bag method. However, in case of drowning you can safely use non-inert gases such as N2O or propane/butane, and much less volume of them is needed (5 - 10 litres should be sufficient). Propane/butane are much more easy to obtain in tech-shops than huge nitrogen cylinders.
Regarding reliability, if you pass out underwater, you gonna be dead. The risk of surviving underwater is nearly zero as long as you don't let other people rescue yourself. There is no uncertainty with taking lethal/non-lethal dosage here, unlike poisoning with SN or CO.