Help DDMA protocol and opioids, need opinions please

[Mayonaise]

I'm planning to go with this method but I'm not sure about the opioid component. The protocol calls for 15g of morphine. It has very poor bioavailability when administered orally
but 15g is a huge dosage, and it was added to the mix for a good reason. Besides sedation and analgesia, its synergy with 1g Diazepam increases the chances of respiratory depression.

Now, the bad news. Opioids are well known for potentially inducing nausea/vomiting, especially when administered orally. If you puke the mixture out, it's game over.
And I guess this is not impossible even with Metoclopramide + Ondansetron.

So, I have two options:

- Skip the opioid altogether, which I guess may potentially hinder time to death

- Use one of the following opioids. I can't get morphine but I may be able to get:

• IC-26 (Methiodone, an analogue of methadone)
• Desmetramadol (O-DSMT) - too weak I guess
• maybe some more potent research opioids

I'm opioid naive and I'm afraid adding one of the aforementioned may induce nausea/vomiting.

Any opinion would be greatly appreciated. Thank you

 

[baberty]

What does DDMA stand for?

 

[Mayonaise]

More opinions, please?

 

[intr0verse]

But the protocol it's being used in countries that allow assisted suicide and they include metoclopramide as an antiemetic, which mean metoclopramide is efficient in preventing vomiting.

 

[Mayonaise]

But the protocol it's being used in countries that allow assisted suicide and they include metoclopramide as an antiemetic, which mean metoclopramide is efficient in preventing vomiting.

Thank you for replying. There are a few approved combinations of antiemetic drugs, depending on the country.

- Metoclopramide
- Metoclopramide + Ondansetron
- Metoclopramide + Haloperidol

So you're right, but what concerns me is the fact that many people requesting MAiD take morphine regularly for cancer pain, thus they are opiate-tolerant. For a opioid-naive like me, I'm afraid the situation might be very different, hence my concern

 

[intr0verse]

Whether a person is opioid-tolerant or not, will not impact the effectiveness of metoclopramide as an antiemetic. Try not to worry or be too anxious about the taste or the vomiting issue; that in itself should reduce the chances of vomiting just by a little bit...

 

[Mayonaise]

Whether a person is opioid-tolerant or not, will not impact the effectiveness of metoclopramide as an antiemetic.

Of course not, but as far as I know opioid-naive people are more likely to vomit when consuming opiates than people with tolerance.

Try not to worry or be too anxious about the taste or the vomiting issue; that in itself should reduce the chances of vomiting just by a little bit...

This is good advice and I agree with you, anxiety can raise the chances of vomiting. Unfortunately, I'm terrified of failing, so vomiting is pretty much my only fear, even though it does necessarily mean failure. It's incredibly hard for me to overcome this fear

 

[intr0verse]

Of course not, but as far as I know opioid-naive people are more likely to vomit when consuming opiates than people with tolerance.

Which is why you'll be using an antimetic that will be effective against vomiting. Also, opioid-tolerant people are more familiar with the taste and the side-effect of opioids so they probably don't worry to much about that.

This is good advice and I agree with you, anxiety can raise the chances of vomiting. Unfortunately, I'm terrified of failing, so vomiting is pretty much my only fear, even though it does necessarily mean failure. It's incredibly hard for me to overcome this fear

I understand, i face the same demon of "what if..."