I've been an agoraphobic hermit for just about half my life now. For me, there's no choice involved in this kind of existence. It's simply what I was born to be. I can't say I particularly enjoy it that much (although I did for a little while during the first couple years), but the alternative, as in going outside, would be even worse. Ultimately, I just try to accept the fact that my "life", such as it is, is just always going to suck, regardless of whatever does, or doesn't happen. At least those who are depressed/suicidal over COVID have a light at the end of the tunnel to look forward to. In my case, I'm totally fucked no matter what happens. I'm "fortunate" that I'll be able to exist as a hermit for the rest of whatever remains of my time on this planet, but even though I enjoy this "luxury" it really only amounts to knowing that I'll be languishing in a musty prison cell, versus languishing out on the street. Either way, my continued misery is a certainty.
At the same time, for those not used to long term isolation I can imagine it must be very jarring/upsetting to deal with, just how someone like me would similarly react if I found myself grappling with the reverse problem. In the sense that if you were to throw someone like me into constant social situations and deny me the ability to seclude myself indoors. Be that as it may, conditional depression on account of quarantine, is very much different versus chronic depression that will never abate regardless of what happens. Inflammatory as it might be to say so, the former will never know true torment and, on that basis, it's near impossible to take what they struggle with all that seriously, frankly. And that's honestly putting it pretty lightly.