Resource Anti-emetics: Reglan vs. Zofran

[Taylor]

A mentions that either one can be used, but I've been doing research on my own and reading a lot of reviews and I'm starting to lean more towards Zofran.

From what I've gathered so far, Reglan (metoclopramide) is a dopamine antagonist that combats nausea and vomiting by primarily speeding up the stomach emptying process and I've heard from numerous sources (and from user accounts here as well) that the side effects are terrible. (Hallucinations, tremors and shaking, swelling, numbness, etc.)

Zofran on the other hand, is a serotonin antagonist and is commonly prescribed to treat chemotherapy or post operative nausea/vomiting, and about 95% of reviews I've read say that it is highly effective and works almost immediately, with the only potential side effects being headaches/dizziness and constipation.

 

[not-2-b-the-answer]

A mentions that either one can be used, but I've been doing research on my own and reading a lot of reviews and I'm starting to lean more towards Zofran.

From what I've gathered so far, Reglan (metoclopramide) is a dopamine agonist that combats nausea and vomiting basically by only speeding up the stomach emptying process and I've heard from numerous sources (and from user accounts here as well) that the side effects are terrible. (Hallucinations, tremors and shaking, swelling, numbness, etc.)

Zofran on the other hand, is a serotonin agonist and is commonly prescribed to treat chemotherapy or post operative nausea/vomiting, and about 95% of reviews I've read say that it is highly effective and works almost immediately, with the only potential side effects being headaches/dizziness and constipation.

Last summer when I was attempting to CTB I did feel sick on the Meto's but I didn't have any of the other side effects.
Maybe I didn't take enough to get the Hallucinations and the other stuff. I think I took 4 doses.
I was going to do the Ahead Regimen instead of the STAT Regimen.
I think if I make another attempt I will do the STAT Regimen. I just don't know how sick I will get … may take some Pepto.
I really don't know what to do anymore … I feel stuck. I'm not quite ready to try again yet but I hope to soon.

 

[Taylor]

I read that nausea and vomiting are also potential side effects of meto, as ironic as that sounds haha. Maybe try Zofran next time? I just worry if it's strong enough to handle an entire 13g N overdose. Everyone's different too, you have to account for that. Some may experience tremors, hallucinations, etc. and others not at all.

 

[Bentham]

Reglan (metoclopramide) is a dopamine agonist that combats nausea and vomiting basically by only speeding up the stomach emptying process.

Would you provide the resource(s) on that?
My understanding of anti-emetics for substance ingestion is based generally on this, and I believe metoclopramide, a Dopamine D2 antagonist, is a treatment for nausea and vomiting by decreasing the activities of chemoreceptors in the Chemoreceptor Trigger Zone.

I have no opinion on which antiemetic is better than the other, but it seems in recent chemotherapy guidelines the first choice of antiemetics is a 5HT3 antagonist such as Ondansetron (Zofran).

 

[Taylor]

My understanding of anti-emetics for substance ingestion is based generally on this, and I believe metoclopramide, a Dopamine D2 antagonist, is a treatment for nausea and vomiting by decreasing the activities of chemoreceptors in the Chemoreceptor Trigger Zone.

Nice! That was my general understanding as well. Not the most official resources, but they do provide ample information while comparing the two side by side, as well as user reviews.

Zofran vs. Reglan Treatment for Nausea and Vomiting: Differences and Side Effects

Zofran (ondansetron) and Reglan (metoclopramide) are antiemetics (anti-nausea and vomiting) used to treat nausea and vomiting.

www.rxlist.com

Reglan vs Zofran Comparison - Drugs.com

Compare Reglan vs Zofran head-to-head with other drugs for uses, ratings, cost, side effects and interactions.

www.drugs.com

It appears that they both block their respective receptors, I guess it comes down to whether you prefer blocking dopamine, or serotonin, but if the first clinical choice is Zofran (and based on user reviews), I think I'd try my luck with that first.

 

[Bentham]

Some more info re antiemetics

The Oral MAiD Option in Canada Part 1: Medication Protocols (2018) P.4
"Recommended antiemetic regimen includes metoclopramide 20mg plus either ondansetron 8-24mg or dexamethasone 8mg taken orally 1 hour prior to the coma inducing medication."
I think this document has well gathered and concise information on the oral ingestion protocol of each nation.

Guidelines for the Practice of Euthanasia and Physician Assisted Suicide (2012) P.17
(automatic pdf download)
"It is essential that the administration of metoclopramide is started one day (twelve hours) in advance in order to minimise the likelihood of the patient vomiting up the of euthanatic agents. Metoclopramide is the anti-emetic of choice as in addition to its anti-emetic effect, it also speeds up gastrointestinal transit."


Dignified Dying (2015) P.20
The first is Meto...The second choice is domperidon...

Guide to Self-Chosen and Humane Death (2006) P.27-28
Same as Dignified Dying

 

[JustOverIt]

A mentions that either one can be used, but I've been doing research on my own and reading a lot of reviews and I'm starting to lean more towards Zofran.

From what I've gathered so far, Reglan (metoclopramide) is a dopamine antagonist that combats nausea and vomiting by primarily speeding up the stomach emptying process and I've heard from numerous sources (and from user accounts here as well) that the side effects are terrible. (Hallucinations, tremors and shaking, swelling, numbness, etc.)

Zofran on the other hand, is a serotonin antagonist and is commonly prescribed to treat chemotherapy or post operative nausea/vomiting, and about 95% of reviews I've read say that it is highly effective and works almost immediately, with the only potential side effects being headaches/dizziness and constipation.

I have heard the same sort of nasty side effects from metoclopramide. However Nitschke has stated that it is the preferred anti-emetic. But there is still a lot of unknowns so I'm sure that Zofran is a good substitute.

Some more info re antiemetics

Guidelines for the Practice of Euthanasia and Physician Assisted Suicide (2012) P.17
(automatic pdf download)
"It is essential that the administration of metoclopramide is started one day (twelve hours) in advance in order to minimise the likelihood of the patient vomiting up the of euthanatic agents. Metoclopramide is the anti-emetic of choice as in addition to its anti-emetic effect, it also speeds up gastrointestinal transit."


Dignified Dying (2015) P.20
The first is Meto...The second choice is domperidon...

Guide to Self-Chosen and Humane Death (2006) P.27-28
Same as Dignified Dying

Nice, thanks Bentham for some solid information.

 

[Bloodtearsdust]

I have been given Zofran in the past, and it is an incredible anti-emetic it dissolves under your tongue and works within 10-20 minutes. One thing I don't see here though is diarrhea. It was a side effect the hospital warned me about... mind you it did not occur until 2 days after taking it. I highly recommend it as far as anti-emetics go.

 

[JustOverIt]

I have been given Zofran in the past, and it is an incredible anti-emetic it dissolves under your tongue and works within 10-20 minutes. One thing I don't see here though is diarrhea. It was a side effect the hospital warned me about... mind you it did not occur until 2 days after taking it. I highly recommend it as far as anti-emetics go.

There you have it. Some solid firsthand information.

 

[spanishguy22]

I've always read meto being the most recommended antie. I guess it's for a reason, but you might be right. Will have to research

 

[Psilo]

I've just ingested a meto pill to see if I dont have side effects. Apparently they are pretty fucked up, I hope Im not included to those who get EPS.

 

[Prénom Surnom]

I already have Zofran and just ordered some Reglan. If that CAMAP organization recommends both, then it's probably the best regimen since they work in different ways. I will test each one separately, but plan to use both now. Thank you for this information; it's extremely helpful to me.

 

[Jen Erik]

I've just ingested a meto pill to see if I dont have side effects.

How did it go? Are you doing okay?

 

[Psilo]

How did it go? Are you doing okay?

Absolutely nothing, took only one tho, when the moment comes I will be taking 4 of those. But I guess I will probably have no side effect before taking the sn, which is a relieve.

 

[Taylor]

I already have Zofran and just ordered some Reglan. If that CAMAP organization recommends both, then it's probably the best regimen since they work in different ways. I will test each one separately, but plan to use both now. Thank you for this information; it's extremely helpful to me.

This might be my plan as well, since it's even greater assurance and has more of a full, rounded-out effect on the Chemoreceptor Trigger Zone as @Bentham mentions, by blocking both dopamine AND serotonin receptors. I'm just going to have to do further research now, to make sure it's safe to take both simultaneously and that there's no interaction between the two.

Some more info re antiemetics

The Oral MAiD Option in Canada Part 1: Medication Protocols (2018) P.4
"Recommended antiemetic regimen includes metoclopramide 20mg plus either ondansetron 8-24mg or dexamethasone 8mg taken orally 1 hour prior to the coma inducing medication."
I think this document has well gathered and concise information on the oral ingestion protocol of each nation.

Guidelines for the Practice of Euthanasia and Physician Assisted Suicide (2012) P.17
(automatic pdf download)
"It is essential that the administration of metoclopramide is started one day (twelve hours) in advance in order to minimise the likelihood of the patient vomiting up the of euthanatic agents. Metoclopramide is the anti-emetic of choice as in addition to its anti-emetic effect, it also speeds up gastrointestinal transit."


Dignified Dying (2015) P.20
The first is Meto...The second choice is domperidon...

Guide to Self-Chosen and Humane Death (2006) P.27-28
Same as Dignified Dying

Nice find! This is some great information.

The Oral MAiD Option in Canada Part 1: Medication Protocols (2018)

Whoa, I just read on page 12 of that article that Metoclopramide acts on both dopamine and serotonin, in addition to "enhancing gastric emptying and gastrointestinal motility". I can see now why this would be the first anti-emetic of choice. I think just for the peace of mind, I'll still consider adding a dose of Zofran, for an additional wall of strength and security. I'm not about to throw up $600 and my only shot at a peaceful ctb attempt, not to mention the added risk of brain damage and being incapable of attempting again.

 

[JustOverIt]

I've just ingested a meto pill to see if I dont have side effects. Apparently they are pretty fucked up, I hope Im not included to those who get EPS.

I have also just taken my first test run dose of metoclopramide (10mg). If anyone would like to know how it goes feel free to ask.

 

[Peaceatlast]

Taylor, you would be wise to use both metoclopramide and Zofran in prep for N. While metoclopramide is actually a first generation antipsychotic drug (aka dopamine antagonism) it's very dirty for that purpose and has not been used for decadesnin the required doses for that means. Yes, terrible side effects in antipsychotic doses but in low doses 10-60mg there are no side effects. It is the drug you take if you get food poisoning while in tropical countries/develp nations.
It stops the physical gag reflex which is critical for the purposes of swallowing N.

Zofran is important because unlike metoclopramide, it is a potent anti-nausea medication and prevents vomitting and regurgitation. You will need this with N because the taste will be very sickening and make you feel sick in the guts and vomit.

I've taken both these meds many times and keep them in medicine cabinet as they are much needed to go meds.

So its not one or the other, you will need both.

 

[Jen Erik]

I have also just taken my first test run dose of metoclopramide (10mg). If anyone would like to know how it goes feel free to ask.

How did it go?

 

[JustOverIt]

How did it go?

Here is what I wrote down about my experience after ingesting 10mg:

• Slightly noticeable change in perception
• No great feeling of hunger or to eat
• Slight agitation and restlessness
• Temporarily 'twitchy'/ jumpy but not in an anxious way
• Actually a bit fun
• Drowsy
• No seriously adverse effects

 

[Jenna]

I have big concerns over meto. Has anyone mentioned how to get it? Would phenergan work the same way?

@JustOverIt im glad that went ok. Did all of that pass?

 

[JustOverIt]

I have big concerns over meto. Has anyone mentioned how to get it? Would phenergan work the same way?

@JustOverIt im glad that went ok. Did all of that pass?

You can get metoclopramide via the link below:

Primperan {METO} for nausea 20 tabs, Sanofi 100% genuine | eBay

100% Genuine EU product, not a cheap generic.

www.ebay.com

Yes more or less. You'll have some residual effects but their wearing off and are very minor.

 

[Jenna]

I have a lot of cog fog. I should have checked what I wrote. I have meto and wonder how to get zofran. I also have phenergan. I was badly prescribed benzodiazepines and the meto concerns me. Thank you so much.

 

[JustOverIt]

I have a lot of cog fog. I should have checked what I wrote. I have meto and wonder how to get zofran. I also have phenergan. I was badly prescribed benzodiazepines and the meto concerns me. Thank you so much.

I'm pretty sure zofran is the only other reliable anti-emetic. I don't think its any easier to get than metoclopramide.

 

[Taylor]

I'm honestly just going to make an appointment with my doctor tomorrow, they're already aware of my ibs issues and I'm pretty sure they were even going to prescribe me meto for that at one time. I'll just say I'd like to give it a try now, but am also battling nausea and would like Zofran as well, since it's worked for me in the past.

 

[lululoo]

Taylor, you would be wise to use both metoclopramide and Zofran in prep for N. While metoclopramide is actually a first generation antipsychotic drug (aka dopamine antagonism) it's very dirty for that purpose and has not been used for decadesnin the required doses for that means. Yes, terrible side effects in antipsychotic doses but in low doses 10-60mg there are no side effects. It is the drug you take if you get food poisoning while in tropical countries/develp nations.
It stops the physical gag reflex which is critical for the purposes of swallowing N.

Zofran is important because unlike metoclopramide, it is a potent anti-nausea medication and prevents vomitting and regurgitation. You will need this with N because the taste will be very sickening and make you feel sick in the guts and vomit.

I've taken both these meds many times and keep them in medicine cabinet as they are much needed to go meds.

So its not one or the other, you will need both.

Peaceful pill recommends just Meto. What makes you so sure both are needed? What is your expertise?

 

[EddieAllenPoe]

Peaceful pill even added dramamine. I'll be honest... that's all I have. Dramamine. I prefer to not order medications illegally. It's a shitty gamble but it's still possible it's sufficient.

 

[Jessica-]

Peaceful pill even added dramamine. I'll be honest... that's all I have. Dramamine. I prefer to not order medications illegally. It's a shitty gamble but it's still possible it's sufficient.

Given what you said above, is your method SN?

 

[Taylor]

Peaceful pill recommends just Meto. What makes you so sure both are needed? What is your expertise?

That was my knowledge as well. Although Zofran is an excellent prescription strength anti-emetic and it can't hurt to increase your chances for success.

Peaceful pill even added dramamine. I'll be honest... that's all I have. Dramamine. I prefer to not order medications illegally. It's a shitty gamble but it's still possible it's sufficient.

I wouldn't trust an OTC anti alone, just my honest opinion.

 

[EddieAllenPoe]

Given what you said above, is your method SN?

Yup. I guess this is more of an N conversation. Kind of similar though. A lot of unknown factors and fear of vomiting.

 

[Jessica-]

Yup. I guess this is more of an N conversation. Kind of similar though. A lot of unknown factors and fear of vomiting.

Yeah, too many unknowns but I don't really have a choice. I have already tried chloroquine and survived.