Futility - The world is a grey and desolated landscape. There's nothing to see, nowhere to go, and nothing to do. Everything is fleeting and more trouble than it's worth.
Suffering - The very crux of existence itself. Unless one is strong enough to weather it, or masochistic enough to enjoy it, then it will constantly devour your every waking moment. The reach of suffering knows no bounds and if ratcheted above too great a level, it very easily destroys even the faintest quality of life. Anhedonia, chronic depression, and boredom are three scourges of suffering that torment me constantly and have essentially become immutable aspects of my daily routine.
Uselessness - I'm a fundamentally useless and broken individual. I do not posses the means to extract any pleasure or meaning from this dismal reality that makes up my existence. I'm genetically aberrant and suffer from many mental defects/illnesses that run contrary to normal human physiology and fundamentally disallow the acquisition of things which are otherwise essential to a fulfilling existence.