Animal Crossing.
Wild World was one of the first games that I got on the DS. I remember being enamored with it immediately as I played it in the car to go back to my aunt's house; the opening scene is one of you moving to a new town in a taxi. It just so happened to also be raining in the game on that specific day I first played, where it was also raining in real life. I thought it was black magic or something lol.
Years later, City Folk on the Wii literally kept me alive in my preteen years during a particularly rough moment in my life where my mom isolated me completely from everything. All I had left was my TV without cable, and the Wii without an internet connection. Those pixels on my TV that cared whether or not I showed my face every day kept me going more than I even understood back then.