My research on depression has led me to discover that there is anecdotal evidence that Tramadol at a sensible and steady dose of 50mg a day (with occasional tolerance breaks) can be miraculous for treatment resistant depression. There are 83 reviews giving it 10 out of 10 on the link below - and lots of these people had tried a range of anti-depressants with no relief.
For any of us without addictive personalities, for whom Tramadol might be risky - this could be a good avenue to try. The side effects are much better than anti-depressants. It's only dangerous (seizures) at high doses, and also to be sensible with it to avoid addiction.
Here are some reviews:
Reviews and ratings for Tramadol when used in the treatment of depression. 234 reviews submitted with a 9.3 average score.
www.drugs.com
I am trying St John's Wort at the moment, and can't combine it - but once I've given this a try and the two week pause needed between an MAOI and Tramadol, I am definitely trying it next.
I know some people will disapprove of opiates, but if you are as close to death from depression as I am, I would say this is worth trying if you can.
I'm just going to add this - which is the rest of my research so far:
Did you try Tramadol yet for depression? I've just heard of it for depression. OTC Coedine does help mine a little - I use it maybe once every few weeks.
There are 83 reviews on this link rating Tramadol as 10 out of 10 for depression:
https://www.drugs.com/comments/tramadol/for-depression.html
Here is a forum of other reviews and discussion on the topic (which includes discussion of addiction risk etc):
https://forum.drugs.com/featured-conditions/tramadol-depression-33499.html
Saying that, I have also just read that the opiate receptors might not be that receptive in people with depression (which might explain how boring I found Heroin when I tried it for the first and only time a few months ago)...but nevertheless, opiates do have hope for Treatment Resistant Depression - this website has a lot of interesting articles on this topic:
https://www.opioids.com/antidepressant/opiates.html