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trek_tattoo_1988

trek_tattoo_1988

Member
Nov 12, 2023
34
Having done a bit of reading around, it certainly SEEMS possible to via a diphenhydramine overdose, commonly found in Nytol tablets. According to two medical journals, in the upper range 40mg per KG bodyweight is lethal. On that basis I'd need about 70 tablets. Surely it can't be that simple?

Just take 70/80 pills with some alcohol and anti-emetics and go to sleep?
 
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ThisUnrest

Seeking personal sovereignty
Aug 15, 2023
178
Its not that simple. Over-the-counter drugs cant kill you, nor can the majority of Rx drugs. Youll just end up very sick, not dead. Possibly with organ damage. It's not a pleasant ride either. Do some reading of past posts on diphenhydramine to learn more.
 
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Praestat_Mori

Mori praestat, quam haec pati!
May 21, 2023
10,194
Here's a guide in combination with hypothermia:

 
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trek_tattoo_1988

trek_tattoo_1988

Member
Nov 12, 2023
34
Its not that simple. Over-the-counter drugs cant kill you, nor can the majority of Rx drugs. Youll just end up very sick, not dead. Possibly with organ damage. It's not a pleasant ride either. Do some reading of past posts on diphenhydramine to learn more.
Sure - but what about the reported lethal levels?
 
Darkover

Darkover

Angelic
Jul 29, 2021
4,162
Forgive me I'm not entirely sure how to read all of that.
What does LD50 mean? ... LD stands for "Lethal Dose". LD50 is the amount of a material, given all at once, which causes the death of 50% (one half) of a group

Diphenhydramine hydrochloride
Mouse Oral LD50 114 mg/kg
Rat Oral LD50 500 mg/kg
Human Oral LDmin. 10.1 mg/kg
 
trek_tattoo_1988

trek_tattoo_1988

Member
Nov 12, 2023
34
What does LD50 mean? ... LD stands for "Lethal Dose". LD50 is the amount of a material, given all at once, which causes the death of 50% (one half) of a group

Diphenhydramine hydrochloride
Mouse Oral LD50 114 mg/kg
Rat Oral LD50 500 mg/kg
Human Oral LDmin. 10.1 mg/kg
Ok so when it's saying LDmin for Human oral, what does that mean? The figures I've read indicate 50mg per kg is lethal, equating to taking about 70 tablets for me.
 
Darkover

Darkover

Angelic
Jul 29, 2021
4,162
Ok so when it's saying LDmin for Human oral, what does that mean? The figures I've read indicate 50mg per kg is lethal, equating to taking about 70 tablets for me.
minimum lethal dose 50mg per kg should be right
 
trek_tattoo_1988

trek_tattoo_1988

Member
Nov 12, 2023
34
minimum lethal dose 50mg per kg should be right
Which brings me around to my original question; surely it's not that simple? 70/80 tablets based on bodyweight. Alcohol to accelerate and anti-emetics to prevent evacuation.
 
Darkover

Darkover

Angelic
Jul 29, 2021
4,162
Which brings me around to my original question; surely it's not that simple? 70/80 tablets based on bodyweight. Alcohol to accelerate and anti-emetics to prevent evacuation.
idk but could be worth a shot whats the worst that can happen end up with damaged organs or as a vegetable
 
S

soleil

Apr 28, 2023
181
If it were that simple a lot of us wouldn't be here. You'll most likely vomit most of it and hallucinate for a while.

This person took about 80pills and was in a month coma, and now suffers from brain damage and seizures.

 

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Darkover

Darkover

Angelic
Jul 29, 2021
4,162
well for my weight 80kg i would need to take 4000mg at 50mg per kg of weight
 
trek_tattoo_1988

trek_tattoo_1988

Member
Nov 12, 2023
34
If it were that simple a lot of us wouldn't be here. You'll most likely vomit most of it and hallucinate for a while.

This person took about 80pills and was in a month coma, and now suffers from brain damage and seizures.

That's helpful thank you. Anti-emetics worth a shot in conjunction then? Based on a 2000mg dose as they're saying, that would only be 40 tablets. I'm leaning towards 80, alcohol, anti-emetics being a viable solution?
 
S

soleil

Apr 28, 2023
181
That's helpful thank you. Anti-emetics worth a shot in conjunction then? Based on a 2000mg dose as they're saying, that would only be 40 tablets. I'm leaning towards 80, alcohol, anti-emetics being a viable solution?

Most DPH are 25mg each so that would be 80. From personal experience, I don't care for Oding on anything otc ever again. Lots of vomiting and blacking out. Getting pumped was one of the most painful experiences. I don't ever want to be sent to the psych ward again!
 
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trek_tattoo_1988

trek_tattoo_1988

Member
Nov 12, 2023
34
Most DPH are 25mg each so that would be 80. From personal experience, I don't care for Oding on anything otc ever again. Lots of vomiting and blacking out. Getting pumped was one of the most painful experiences. I don't ever want to be sent to the psych ward again!
Ok thank you, that's also insightful.
 
IsThisEverything

IsThisEverything

Member
Nov 1, 2023
88
People have died from a DPH overdose, I know from speaking to a paramedic about it. I once took about 1200mg at once. I was at a fairly low weight at the time and hoped it would be enough, it was all I had. My research suggested that doses upwards of 1000mg can be fatal. It didn't kill me obviously. I was just very delirious. Maybe around 4000mg would do it, however it is not certain and can have significant long term consequences if you survive it.
 
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