I'm 5'5 and around 105lbs, 70x40mg pills was enough for me to flatline in December. I was unconscious by the time I was found seizing, cardiac arrest is what caused me to flatline. To save me I was put into a medically induced coma, my family were warned of brain damage and I was still expected to die until I woke up so I'd imagine brain damage is likely if you survive and I got pretty lucky. I didn't use antiemetics, mix them with any other drug or crush them, I just swallowed them all with a glass of water first thing in the morning on an empty stomach. I don't remember being in pain before I lost consciousness either so painless as far as I'm aware.
Just adding that it was actually an effort for the nurses to pull me out of this attempt, took 2 ambulances, 40 mins of chest compressions, intubation, coma, etc. I think this is a pretty reliable way to go. I was told by paramedics when I went back a month after for heart related issues (probably due to this attempt) that they all expected me to die & the first one to treat me cried when she saw me alive. If I am to CTB I'll use propranolol again.