Overdosing on valproic acid (depakote)

[tuto170]

What would be the lethal dose? And how would it go?

 

[Girobatol]

I read is like 7 grams, not that much. However, who knows and seems risky to me.

 

[allgood]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884232/ suggests 'severe toxicity' begins around 400mg/kg. Probably a fairly large amount of tablets if they're extended release.

I'm not sure anyone alive can tell you exactly how it would go; https://pmj.bmj.com/content/postgradmedj/62/727/409.full.pdf in this case 25g caused unconsciousness after around 3 hours, doesn't sound great.

 

[gingerplum]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884232/ suggests 'severe toxicity' begins around 400mg/kg. Probably a fairly large amount of tablets if they're extended release.

I'm not sure anyone alive can tell you exactly how it would go; https://pmj.bmj.com/content/postgradmedj/62/727/409.full.pdf in this case 25g caused unconsciousness after around 3 hours, doesn't sound great.

A complete recovery after 25 gm Valproic acid, plus moderate doses of Restoril and Valium. I dunno, sounds super iffy to me.

Plus, Valproic acid is metabolized in the liver... if you survived a massive dose but fried your liver, that would be bad. Like holy shit, that's bad, whoa bad.

 

[Stan]

if you survived a massive dose but fried your liver, that would be bad. Like holy shit, that's bad, whoa bad

So let me get it clear.....its bad then?

 

[gingerplum]

So let me get it clear.....its bad then?

Yeah. As in, not good . Awful. A real fucking bummer.

 

[Stan]

Yeah. As in, not good . Awful. A real fucking bummer.

Just wanted to make sure as I don't think you were explicit enough

 

[gingerplum]

Just wanted to make sure as I don't think you were explicit enough

It'll fuck up your day, Sweet Cheeks.

 

[Stan]

It'll fuck up your day, Sweet Cheeks

Not quite Shakespearean enough for a Brit - but I will take it

 

[BridgeJumper]

So the general consensus is that its bad to overdose on
I have a lot stocked in my drawer and wanted to take them but guess I need to change methods or combine it with something more lethal

 

[tuto170]

A complete recovery after 25 gm Valproic acid, plus moderate doses of Restoril and Valium. I dunno, sounds super iffy to me.

Plus, Valproic acid is metabolized in the liver... if you survived a massive dose but fried your liver, that would be bad. Like holy shit, that's bad, whoa bad.

I might get next week 45grams and if I would get my liver would I die as well?

 

[gingerplum]

I might get next week 45grams and if I would get my liver would I die as well?

That's just the thing... I don't know. I'm so sorry, I wish I could tell you something more definitive. My concern is if you survive, will you have any liver function left?

Better start researching and do some really deep diving on this method before you attempt it.

 

[tuto170]

That's just the thing... I don't know. I'm so sorry, I wish I could tell you something more definitive. My concern is if you survive, will you have any liver function left?

Better start researching and do some really deep diving on this method before you attempt it.

The problem is there is not enough resources but as stated it would just put me into coma and kill within hours

 

[gingerplum]

The problem is there is not enough resources but as stated it would just put me into coma and kill within hours

And I don't mean to frighten you away from what may very well be a super legit method. I'm an experienced nurse, so I want for everyone to get the outcome they want without creating any unforeseen problems