Opioid overdose

[weedoge]

Antiemetics including:

• • Dolasetron (Anzemet) can be administered in tablet form or in an injection.
  • Granisetron (Kytril, Sancuso) can be administered in tablet (Kytril), oral solution (Kytril), injection D(Kytril), or in a single transdermal patch to the upper arm (SANCUSO).
  • Ondansetron (Zofran) is administered in an oral tablet form, orally dissolving tablet form, orally dissolving film, sublingual, or in an IV/IM injection.
  • Tropisetron (Setrovel, Navoban) can be administered in oral capsules or in injection form.
  • Palonosetron (Aloxi) can be administered in an injection or in oral capsules.
  • Mirtazapine (Remeron) is an antidepressantthat also has antiemetic effects[4][5] and is also a potent histamine H1 receptor antagonist, Ki=1.6 nM.[6]
• Dopamine antagonists act in the brain and are used to treat nausea and vomiting associated with neoplastic disease, radiation sickness, opioids, cytotoxic drugs and general anaesthetics. Side effects include muscle spasms and restlessness.[3]
  • Domperidone (Motilium)
  • Olanzapine (Zyprexa)
  • Droperidol, haloperidol, chlorpromazine, prochlorperazine. Some of these drugs are limited in their usefulness by their extra-pyramidal and sedative side-effects.
  • Alizapride
  • Prochlorperazine (Compazine, Stemzine, Buccastem, Stemetil, Phenotil)
  • Metoclopramide (Reglan) also acts on the GI tract as a pro-kinetic, and is thus useful in gastrointestinal disease; however, it is poor in cytotoxic or post-op vomiting. also a

• • Buccastem, Stemetil, Phenotil)
  • Metoclopramide (Reglan) also acts on the GI tract as a pro-kinetic, and is thus useful in gastrointestinal disease; however, it is poor in cytotoxic or post-op vomiting. also a 5-HT3receptor antagonists
• NK1 receptor antagonist
  • Aprepitant (Emend) is a commercially available NK1 Receptor antagonist
  • Casopitant is an investigational NK1 receptor antagonist
  • Rolapitant (Varubi) another recently approved drug from this class
• Antihistamines (H1 histamine receptorantagonists) are effective in many conditions, including motion sickness, morning sickness in pregnancy, and to combat opioid nausea.
  • Cinnarizine, available in the UK.
  • Cyclizine
  • Diphenhydramine (Benadryl)
  • Dimenhydrinate (Gravol, Dramamine)
  • Doxylamine
  • Meclizine (Bonine, Antivert)
  • Promethazine (Pentazine, Phenergan, Promacot) can be administered via a rectal suppository for adults and children over 2 years of age.
  • Hydroxyzine (Vistaril)
• Cannabinoids are used in patients with cachexia, cytotoxic nausea, and vomiting, or who are unresponsive to other agents. These may cause changes in perception, dizziness, and loss of coordination.[3]
  • Cannabis, also known as medical marijuana in the United States, is a Schedule Idrug.[citation needed]
  • Dronabinol (Marinol/Syndros) is a Schedule IIIdrug in the U.S.[citation needed]
  • Some synthetic cannabinoids such as Nabilone (Cesamet) or the JWH series.
  • Sativex is an oral spray containing THC and CBD. It is currently legal in Canada and a few countries in Europe but not legal in the U.S.[citation needed]
• Benzodiazepines
  • Midazolam (Versed) is given at the onset of anesthesia and has been shown in recent trials to be as effective as ondansetron.[citation needed]
  • Lorazepam (Ativan) is said to be very good as an adjunct treatment for nausea along with first line medications such

This is interesting but you need dopamine blockers for drug induced vomiting, the others won't have a significant effect. Motion sickness/anti histamine pills, no matter how many, won't stop you vomiting a shitload of toxic drugs up.

This is good info but for safety may be better off giving context. Even the dopamine blockers have different strengths which are more likely to cause EPS but also less likely to cause vomiting. That's why people tend to go for the "mid level" metoclopramide and that's the anti emetic you hear people talking about the most.

 

[weedoge]

The human body employs several distinct mechanisms to trigger vomiting in response to different stimuli. It follows that there is no universal antiemetic that would prevent vomiting irrespective of the cause; indeed, each particular antiemetic drug targets a specific vomiting mechanism. For instance, medicines used to prevent motion sickness will not work to stop nausea caused by general anaesthesia.

• Most over-the-counter (OTC) antiemetics are intended to alleviate travel sickness. Examples of such a drug is dimenhydrinate (Dramamine, Gravol). They work through the histaminic receptors and the cholinergic receptors; thus, they would not be suitable for the prevention of drug-induced vomiting, which is triggered by other neurotransmitters.
• Another class of antiemetics that would be slightly more efficient for drug-induced vomiting is that which is used for post-surgery and chemotherapy-induced emesis. This drug class acts by inhibiting the 5-HT receptors (serotonin blockers and drugs that work through the vagus nerve), primarily the 5-HT3 receptor. To some extent, these drugs can lower the instance of drug-induced vomiting, but they are not the antiemetic of choice for this purpose: dopamine, not serotonin, is the main neurotransmitter for triggering the brain's vomiting centre when a drug overdose occurs. However, it may be advisable to use a 5-HT3 antagonist as a complement to a dopamine blocker

No matter which option of the three mentioned below you decide to use, please apply a short and controlled test, just to confirm that you are not allergic to that specific antiemetic and to avoid any unexpected side effects in your actual suicide attempt. The test should include no more than a 10 mg dose to see if you are somehow badly affected by this antiemetic. If so, you might want to test an alternative. It could also be worth trying a higher dose to see if tendencies of EPS would occur. In this case, try the procedure well in advance and then stop to avoid building a tolerance.

In the drug cocktails described on this wiki which rely on sedatives (which any reasonable cocktail would), the sedatives should take effect in less than 10 minutes. Nevertheless, this means that we need the protection of an antiemetic (or antiemetics, depending on your preference) for a short period of time, until the sedatives depress the central nervous system, thus ultimately also depressing the vomiting centre in the brain, therefore preventing any chance for emesis to occur.

Vomiting is a very real risk, so drug overdosing without antiemetics is potentially problematic with regard to successfully achieving a peaceful and successful end to one's life and should not be tried (unless failure or a painful death by choking a la Jimi Hendrix is sought). There are few accounts of vomiting from Dignitas and in reports on physician assisted suicide in the Netherlands, which suggests antiemetics are effective for most people. However, severe gastrointestinal issues due to disease render oral consumption of the drug unsuitable, unfortunately.

taken from the antiemetic regimen wikibooks page: https://en.wikibooks.org/wiki/Suicide/Toxification/Antiemetic_regimen

 

[weedoge]

I'll try that link. One was the "amitriptyline cocktail". It adds an antacid ...cimetidine? Do not know if it should be added to opioids. I think i
I'd feel better if I had more Benzos. I did the same thing with meds...began filling them anyway...they are all gone now. In about 10 days, I'll have more, but I've got this house all to myself right now. After that, it gets busy and awful...a fate worse than death...truly

Cimetidine is just to potentiate the amitriptyline

 

[Dani Paradox]

From what I've read, it's generally unreliable. You're breathing could just become so low that it causes brain damage, and then you could survive the OD and wake up even more fucked up than you already are. It happens.

 

[weedoge]

From what I've read, it's generally unreliable. You're breathing could just become so low that it causes brain damage, and then you could survive the OD and wake up even more fucked up than you already are. It happens.

Do you have a source? I've read that when injecting and without tolerance, it's reliable. No idea about orally with liquid. Taking morphine tablets orally is generally unreliable, though.

If a person has the skill to self-inject into one's muscle and provided that one is "clean", 500 milligram of morphine would be reliably lethal. If injected into a vein, less than 500 mg of morphine would be reliably lethal (according to Dr. Admiraal's book mentioned above).

 

[Dani Paradox]

Do you have a source? I've read that when injecting and without tolerance, it's reliable. No idea about orally with liquid. Taking morphine tablets orally is generally unreliable, though.

Aye, I have no idea what forums I was on when I was reading up on it. Even injecting a heroin OD is unreliable. I suppose if you took a RIDICULIOUS amount then you would surely die, but who knows what that dosage is.

 

[weedoge]

Aye, I have no idea what forums I was on when I was reading up on it. Even injecting a heroin OD is unreliable. I suppose if you took a RIDICULIOUS amount then you would surely die, but who knows what that dosage is.

Injecting heroin is completely different because it's always cut, and it's one of the most cut drugs on the street . I'd never suggest anybody to od on heroin.

No euro data but here:

Analysis by the Drug Enforcement Administration (DEA) shows that the purity of heroin has increased in recent years. Mexican-South American heroin purity slightly declined, from 74% in 2014 to 70% in 2015 (which is still quite high). However, purity in South America-only heroin increased from 61% to 63% over the same time period, purity in Southwest Asian heroin increased from 35% to 54%, and purity in Inconclusive Origin-South American heroin increased from 39% to 51%.

We're talking about morphine the pure medical drug, doctors know what that dosage is. 500mg intramuscular or less into a vein, with no tolerance.

 

[Swisher]

Cimetidine is just to potentiate the amitriptyline

Cimetidine is just to potentiate the amitriptyline

Hilo. Okay, I thought it might be just for amitriptyline which saves me the errand of picking up Tagamet which is hard to find. This is kind of why I said maybe less is more? More than you normally take but less than would make me vomit. Question- (don't worry if you can't respond) 1) Let's say I stop breathing for over two minutes or 20 and wake up...is that what you mean about brain damage? I do not want to be a vegetable. I already feel like one. I was just going to take the dose of amitriptyline that I'm used to because it induces my sleep. I do not want tardive dyskinesia! ( and of course, this is why I would like a partner, J, ya know? & possibly go to D.C or Oregon where it's legal - to the extent that they are more tolerant). I'm am doing a tiny practice session to see if my Zofran works. I will soon be pain-free! Which may make me temporarily happy.I will try not to be a buzz-kill)

 

[Swisher]

J, it didn't include you in my reply just now at 1:17p eastern?

 

[Swisher]

I was also kind of wondering what you thought about the paste idea? Does bypass? Why shouldn't I do that then?

 

[Swisher]

Injecting heroin is completely different because it's always cut, and it's one of the most cut drugs on the street . I'd never suggest anybody to od on heroin.
But, injecting should work then, simply using a ridiculous amount? I can't do that. Just wondering...i.e. I liquify my methadone ...(surely passing before I got enough in my system. Sorry, I'm new, & have a lot of questions. As you know, It's ok, not to respond & I'll shut up).

No euro data but here:


We're talking about morphine the pure medical drug, doctors know what that dosage is. 500mg intramuscular or less into a vein, with no tolerance.

 

[Swisher]

Can anyone suggest how/where to buy roxicodone and/or fetanyl? I live in Denmark - the post office catches all incoming pills.
Thanks

The DEA has made that nearly impossible...I think. New laws leaving people in pain to suffer and doctors afraid to prescribe. I think you could only get TOR troll around and carefully sample. Not thru mail? I can only think you'd have to go on holiday/take a vacation to wherever...Expensive and risky?

 

[Jameson]

J, it didn't include you in my reply just now at 1:17p eastern?

What was the question? My memory is shot these days. Something I said last night ? Sorry.

 

[Jameson]

What was the question? My memory is shot these days. Something I said last night ? Sorry.

Ok remember. The powder into paste to plug. . I need to look that up. It's a theory on how they killed Marilyn Monroe back in the day. Most of the pills they found in her stomach were undisolved .

 

[Swisher]

Ok remember. The powder into paste to plug. . I need to look that up. It's a theory on how they killed Marilyn Monroe back in the day. Most of the pills they found in her stomach were undisolved .

Big fat fail. Trial run. Maybe should have eaten...just took a few and 1/2 Zofran. I vomited. Totally sick. Massive headache. There's a chance there wasi another reason and I haven't really eaten in 3 days, but you'd think the Zofran would've worked...

 

[Swisher]

If you have little to no tolerance to opioids, that combo would most certainly kill you. 600mg of the Roxi would probably be enough with a few swigs of hard tack. Oxy overdose is right up there for most humane methods to exit, imo.

True. Unless I try.
Btw, with absolutely no tolerance and in pain, a doctor gave me two hydrocodone...I vomited... I have bunches of Zofran now. I would love to know (& will post this anywhere some will answer) after all I've read why 30 methadone 10mg, 8mg Zofran, a few amitriptyline (just because I use then for sleep & they're nasty little things), clonidine - nice low blood pressure/works great with methadone, valium 50 .5mg, butalbital ( going fast) but acquired 2 days ago for my lovely brain bleed, ....toss I the Tagament cimetidine...ALL together... Why would that not work? I did a trial run and became violently ill...had no idea what I was doing, saying. That made no desde either. I've taken more? I was having a lovely stroke. Sorry to all that received my msgs.

 

[Obliged to do it]

I was thinking of using bunch of opiods and alcohol but it doesnt seem to be a reliable method.
I guess making some drug cocktail would have a higher chance but theres always risk with vomiting.

Hmmm, i wonder if there is a higher chance of becoming a vegatable after ODing or partial suspension hanging.

 

[Swisher]

Glad to see you again

 

[Duqu]

If I do decide to go the route of opioid OD I plan on plugging so there's no way of puking it up.

 

[Swisher]

If I do decide to go the route of opioid OD I plan on plugging so there's no way of puking it up.

I thought you'd tried this

 

[Duqu]

I thought you'd tried this

Nope. Never put anything up my butt before. :P

 

[Swisher]

Nope. Never put anything up my butt before. :P

I just don't know how that would go for me...I promise it wouldn't end up anywhere close
Im just that skilled

 

[Swisher]

The worst thing about suicide..
It CANNOT happen. Mathematically, that is ...unless your doing it to preserve the race...Someone else. Our bodies and brains suck.

I need to Do it perfectly peacefully. If "Price" ( below) can Do this, there's an Edison to overcome it. Otherwise you must have assistance and ID GLADLY PAY FOR IT.
https://en.m.wikipedia.org/wiki/George_R._Price

 

[Swisher]

I just don't know how that would go for me...I promise it wouldn't end up anywhere close
Im just that skilled

I'm terrified. I've got to do this. But no one can...unless lucky
https://en.m.wikipedia.org/wiki/George_R._Price
All this means is this:

https://m.scoop.co.nz/stories/HL0003/S00026/suicide-is-painless-the-craccum-articles.htm

I need help. Assistance. Now. I don't know how you put up with what you do. I can't put up with my body's willingness to torture me damage poor bodies and yet continue to protect us completely.

 

[Roehannta]

The trick is not to vomit, right? My body is a huge fan of barfing. So, how about reducing? You don't always have the luxury of time. But, Methadone & 24 hours slowly taking taking a few to feel sleepy... I read that 200mg is lethal even if you're tolerant. Now, that can't be true. Some people take that everyday. But, It's predicated upon the fact your supposed to be cut off at 120mg. I have taken my dose down to 1.5 per day for almost a month. The more you take, that your body can't handle, the more likely you are to barf. I know I can take 6 tablets at once, but then I get very nauseas. I was falling asleep sitting up & I cannot sleep at all without amitriptyline. I love being tired. I treat myself to a few extras when I can. I don't get high but the pain is gone and I can't stay awake. It is lovely! So, what do you think about lowering the dose, actually? Take only
30 × 10mg (of the 60 I'll have). Valium 6 or so. Zofran 8mg. Amitriptyline 5 or 6. Clonidine a couple. Plavix- thinning the blood like alcohol. I gave a trial run last night. My breathing slowed so much, I would take huge breathes and was awakened by them. So, less maybe...with time to let your body adjust over 4 hours (or whatever time you've got, 6, 12 or 24). Set your alarm for a few hours in, and take all the rest crushed or even liquefied with alcohol. & maybe add antacid. Less is more?

Hey you. I'm
Back.

 

[Duqu]

[QUOTE="Jameson, post: 60245, member

• • Ondansetron (Zofran) is administered in an oral tablet form, orally dissolving tablet form, orally dissolving film, sublingual, or in an IV/IM injection
• • Droperidol, haloperidol, chlorpromazine, prochlorperazine. Some of these drugs are limited in their usefulness by their extra-pyramidal and sedative side-effects.
  • Metoclopramide (Reglan) also acts on the GI tract as a pro-kinetic, and is thus useful in gastrointestinal disease; however, it is poor in cytotoxic or post-op vomiting.

• Cannabinoids are used in patients with cachexia, cytotoxic nausea, and vomiting, or who are unresponsive to other agents. These may cause changes in perception, dizziness, and loss of coordination.[3]
  • Cannabis, also known as medical marijuana in the United States, is a Schedule Idrug.[citation needed]
• Benzodiazepines
  • Midazolam (Versed) is given at the onset of anesthesia and has been shown in recent trials to be as effective as ondansetron.[citation needed]
  • Lorazepam (Ativan) is said to be very good as an adjunct treatment for nausea along with first line medications such

[/QUOTE]


This was very helpful, thank you. I have HUUUUGE amounts of Zofran because I keep filling it even though it's long since stopped working (I'm prescribed 8mg dissolving tablets and I take like 6 to get minor relief). I take 400mg chrorpromazine / Thorazine every night for insomnia and can vouch for its efficacy as an anti-emetic. Normally having the amt of volume in my stomach I need to take my night pills (large number of pills plus water) would make me throw up (yaaay eating disorder of 18 years!) NOT on purpose but the thorazine prevents that. If I KTB via OD (and not buttpug it) I plan to take a large dose (maybe 3x my usual dose) A for sleeping through the SN effects (though I'll take benzos and opioids too but I have a tolerance to some of the opioids I'll be taking, just not the propoxyphene, methadone, or oxycodone which I have a fair bit of. The ones I'm used to are morphine and dilaudid but still have a fair amt of that too).

I did NOT know ativan is good for nausea; do you know if it's any good for seizures? I take 2mg klonopin at night to try to prevent seizures at night (I have tonic-clonic / grand mal seizure epilepsy). Would I get anywhere asking my neuro to switch from kpin to ativan?

 

[Roehannta]

Promethazine is a dopamine blocker? Swear you need dopamine blockers to stop drug induced vomiting

I wanted to get involved with this thread and ask a few questions
So my question is. Is a person takes approx 180-200 mg of oxycodone (Roxy 30 mg )daily along with a 10 mg Valium at night. Would this person be able to be successful with say 1250 mg roxy. instant release. Mix in maybe 15-20 of the 10 mg Valium , 2 half pints of whiskey. But He would start with a mixture of maybe 20 of the time release 27 mg xtampza crushed up ( one 27mg xtampza is supposed to be equivalent to 40 mg of oxycodone). This person also have 750 mg Methocarbamol muscle relaxers. And then He has a good supply of promethezine for nausea. Is this person going to have a problem with this because of his tolerance ? I know you said that he would need a antiemetic as well. So say he gets the antiemetic. Is this a combination that would be successful ? Suggestions?

 

[Duqu]

I wanted to get involved with this thread and ask a few questions
So my question is. Is a person takes approx 180-200 mg of oxycodone (Roxy 30 mg )daily along with a 10 mg Valium at night. Would this person be able to be successful with say 1250 mg roxy. instant release. Mix in maybe 15-20 of the 10 mg Valium , 2 half pints of whiskey. But He would start with a mixture of maybe 20 of the time release 27 mg xtampza crushed up ( one 27mg xtampza is supposed to be equivalent to 40 mg of oxycodone). This person also have 750 mg Methocarbamol muscle relaxers. And then He has a good supply of promethezine for nausea. Is this person going to have a problem with this because of his tolerance ? I know you said that he would need a antiemetic as well. So say he gets the antiemetic. Is this a combination that would be successful ? Suggestions?

An antiemetic IS an anti-nausea med. So Promethazine is an antiemetic.

https://en.wikibooks.org/wiki/Suicide/Toxification/Antiemetic_regimen

https://www.ncbi.nlm.nih.gov/pubmed/10918098
i.e. Promethazine is NOT the same as Prochlorperazine (despite them both ending in "zine" that tricked me for a bit until I did a bit of googling before potentially giving you the wrong info)

I used to take 25mg Promethazine and it did zilch for my nausea (everyday nausea, not OD nausea). As does Zofran but I have a tolerance. I bought Primperan (Metoclopramide) on ebay for $20.99 (I'm in US) but I believe the price has gone up as the seller has noticed a spike in buyers since I posted the link lol. It came from greece, and it arrived in 10 days with the customs label of "vitamins" no problems whatsoever. Though all the instructions are very literally in Greek lol.

 

[Duqu]

Oh duh I should include a URL. Don't know what country you're in but this is where I got it on Ebay (I'm in US):

https://www.ebay.com/itm/primperan-20tabs-for-nausea/173350981946?_trksid=p2485497.m4902.l9144

 

[Deutschv2]

would i throw up from 20 mg fent taken orally?