Tissue heating is the principal mechanism of interaction between radiofrequency energy and the human body. At the frequencies used by mobile phones, most of the energy is absorbed by the skin and other superficial tissues, resulting in negligible temperature rise in the brain or any other organs of the body.
Epidemiological research examining potential long-term risks from radiofrequency exposure has mostly looked for an association between brain tumours and mobile phone use. However, because many cancers are not detectable until many years after the interactions that led to the tumour, and since mobile phones were not widely used until the early 1990s, epidemiological studies at present can only assess those cancers that become evident within shorter time periods.
Human health studies are very good at identifying large effects, such as a connection between smoking and cancer. Unfortunately, they are less able to distinguish a small effect from no effect at all. If electromagnetic fields at typical environmental levels were strong carcinogens, then it would have been easy to have shown that by now. By contrast, if low level electromagnetic fields are a weak carcinogen, or even a strong carcinogen to a small group of people in the larger population, that would be far more difficult to demonstrate.
In fact, even if a large study shows no association we can never be entirely sure that there is no relationship. The absence of an effect could mean that there really is none. But just as well it could mean that the effect is simply undetectable with our method of measurement. Therefore, negative results are generally less convincing than strong positive ones