Hey I don't know anything about your condition but if it's the aftereffects you're suffering from this could help as the dysfunction may result from similar mechanisms in other afflictions within the sphere of CFS, fighting neuroinflammation seems to be at the crux of treatment
Dapansutrile (novel inflammasome for CFS)
[Final verdict on the safety of Cerebrolysin? : Nootropics](https://www.reddit.com/r/Nootropics/comments/odx7hk/final_verdict_on_the_safety_of_cerebrolysin/)
Thats rough. I have both whats considered Osmotic demyelination syndrome and Onleys lesions from malpractice. Nothing from concussive injuries.
. . .
If we're talking about the magnitude of severe TBI, As far as our research shows to the best of my knowledge what happens in TBI is that excessive stress/damage induces senescence in brain tissue, which is the case for all cells in the body. Senescence is basically when cells decide to shut down and refuse to function. The build up of these cells is a major pillar that drives ageing forward as well. [Senescent cell build up](https://academic.oup.com/ppar/article-abstract/23/4/12/2937237?redirectedFrom=PDF) is a major cause of inflammation, which is a crucial aspect of your body that you want to get under control when you're dealing with damage. The easiest way of removing senescence is through a pathway called [autophagy](https://www.healthline.com/health/autophagy) which is the " body's way of cleaning out damaged cells". A class of medication called [senolytics](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405395/) helps in this region. Supplements like [fisetin](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197652/) & [Quercetin](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808895/) aid in clearing senescent cells from the body as well as [fasting](https://pubmed.ncbi.nlm.nih.gov/31810345/) and [Hyperbaric oxygen therapy](https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.039217)
/Its recommended you talk to your doctor and get proper blood work before fasting because it can be dangerous without knowing what to do/
. .
Fasting and senolytics I feel like are what made the biggest difference. Every heavy fast/senolytic combo I went though I could feel the inflammation and pain going away in my head. [r/FMD](https://www.reddit.com/r/FMD/) and [Prolon](https://prolonfmd.com/) are great for if fasting is to much, so they created "Fasting Mimicking Diet"
I coupled senolytic therapy with peptide therapy which is where Cerebrolysin came in. Among the other peptides ;
[Thymosin Beta 4](https://pubmed.ncbi.nlm.nih.gov/26805386/)
[BPC157](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333585/)
[GHKcu](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073405/)
[B7-33](https://pubmed.ncbi.nlm.nih.gov/32295457/)
[Ipamorelin](https://pubmed.ncbi.nlm.nih.gov/9849822/)
[modGRF](https://pubmed.ncbi.nlm.nih.gov/15817669/)
Because [autohpagy helps stem cells](https://www.frontiersin.org/articles/10.3389/fcell.2020.00138/full) the [thymosin beta 4 helps guide](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392183/) what they should be doing.
. .
BPC157 and Thymosin Beta 4 both have synergistic effects that work in tandem with peptides GHKcu & [B7-33](https://pubmed.ncbi.nlm.nih.gov/32295457/) because of their ability to [reverse scar tissue] ( [
https://pubmed.ncbi.nlm.nih.gov/18644225/](https://pubmed.ncbi.nlm.nih.gov/18644225/) ) & [tone down gliosis](https://pubmed.ncbi.nlm.nih.gov/27163643/) which tend to be the major barriors from allowing your brain from healing properly. Lastly,
/it is recommended you speak to your doctor before pursuing growth hormone/
Ipamorelin & modGRF potentiate the growth of system.
[10](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664031/) . [11](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020593/) . [12](https://pubmed.ncbi.nlm.nih.gov/10479465/) .
As far as supplements go, I used ;
[AlphaGPC](https://nootropicsdepot.com/alpha-gpc-150mg-capsules/)
[Triacetyluridine](https://nootropicsdepot.com/triacetyluridine-powder/)
[Krill oil](https://vivanaturals.com/products/krill-oil)
[Curcumin](https://nootropicsdepot.com/longvida-curcumin-capsules/)
[Lions mane](https://nootropicsdepot.com/lions-mane-mushroom-capsules-8-1-extract/)
[CordyCeps](https://nootropicsdepot.com/cordyceps-mushroom-capsules-10-1-extract/)
[Nicotinamide riboside](https://www.truniagen.com/truniagen-300mg/)
NAC
As far as lifestyle goes, exercising is important. If you can find a gym that has a [sauna](https://pubmed.ncbi.nlm.nih.gov/22917237/) it will really help your effort. *—————————————————————————————————*
Its taken me close to 3-4 years to fix this. Id say about 95% of it has gone away. Theres still traces of pain left over but I am exponentially further ahead than where I started and am still making considerable progress. I feel cognitively the same again
[I Need help choosing some peptides: I have had three head injuries and am 56 years old. I'm looking for suggestions for brain health and function as well as overall health and longevity I have issues with sleep and anxiety, thanks. : Peptides](https://www.reddit.com/r/Peptides/comments/tv8hpk/i_need_help_choosing_some_peptides_i_have_had/)
