Ketamine and Depression

[markg109]

I've noticed that many of you on here are suffering from depression, no big surprise there right? Also, most seem to be quite young. I suffered from mild to moderate depression at different times in my life, as most people on the planet do.

I suffer from Ehlers-Danlos syndrome, a connective tissue disorder which can (and does in my case) cause severe chronic pain. 10 yers ago I went to a pain specialist who thinking outside of the box treated me with Ketamine, sort of unheard of at the time. Not only did it help my pain, but once I reached the correct dosage (in my case .0.9 ml IM) I was immediately free of depression. I mean I was totally over my depression with one injection! This lasted for months, even when I stopped taking the ketamine. There is an approved nasal form called eskaetmine, however I have read that it's very expensive (Thanks big pharma), and Dr.'s use it as a last resort, when in my opinion it should be the gold standard of treatment. Will it work for everyone? There is not enough evidence, but before you take a permanent step, like ending your life, please try ketamine treatment, even if you have to acquire the ketamine on your own.

I'm not on this site because I'm depressed, I've lived a great life, I'm almost 60, and my disability has caused me to lose the ability to walk or do the things that I've always enjoyed, and my pain is most times unbearable, even with the large amount of opiates I take. I just know that ketamine could help some of you as it helped me, and knowing that I've been depression free for years has made my disease tolerable. Best of luck to you all and god bless you

 

[RodgerThat]

Very helpful info, cheers! Did it drain the energy out of you, though?

 

[markg109]

Very helpful info, cheers! Did it drain the energy out of you, though?

Thanks for the kind words. Not at all, in fact everything became much clearer, food tasted better, colors looked brighter, long after the effects wore off. A word of caution though go slow, as too much can cause a dissociative state, (aka K hole) it is not, as some might argue, a pleasant experience in my opinion.

 

[RodgerThat]

Thanks for the kind words. Not at all, in fact everything became much clearer, food tasted better, colors looked brighter, long after the effects wore off. A word of caution though go slow, as too much can cause a dissociative state, (aka K hole) it is not, as some might argue, a pleasant experience in my opinion.

I see. So moderation is good then? Maybe I will see if I can source some in the UK at some point, though I only suffer from mild physical pain.

 

[GeorgeJL]

Yeah I've been telling people on here to try ketamine. I don't think they understand how valuable it can be. The other day I had to defend myself from people accusing me of recommending psychedelics like ketamine. I'm glad that I am not the only one that knows the benefits of psychedelics, especially ketamine. Hopefully some people on here will be brave enough to give it a shot.

 

[Fin]

I read this article (click on the image) a few days ago about how ketamine exerts its antidepressant effects. Found it interesting.

 

[Dead beat dad]

I did some ketamine when I was a kid recreationally.
All I really remember was hitting my head really hard on something (it made a sound so loud you heard over the noise in the club), everyone stopped and looked at me like I should have had a gaping head wound or something, but I didn't feel a thing.
I almost remembered something else then.

 

[markg109]

I did some ketamine when I was a kid recreationally.
All I really remember was hitting my head really hard on something (it made a sound so loud you heard over the noise in the club), everyone stopped and looked at me like I should have had a gaping head wound or something, but I didn't feel a thing.
I almost remembered something else then.

The amount of Ketamine that you do is critical, and the route taken (IM vs oral administration is much more effective), you can really harm yourself with too much, you almost feel as if you're wrapped in cotton baton, and feel absolutely no pain. But it's anti depressant ability is amazing!

Yeah I've been telling people on here to try ketamine. I don't think they understand how valuable it can be. The other day I had to defend myself from people accusing me of recommending psychedelics like ketamine. I'm glad that I am not the only one that knows the benefits of psychedelics, especially ketamine. Hopefully some people on here will be brave enough to give it a shot.

Totally agree with you, I think that the psychiatric community (M.D.'s), have been too quick to give up on psychedelic drugs, they can be amazingly useful in the proper environment.

 

[soda_pressed]

Can confirm. I know someone that has depression and takes k recreationally and notices a big mood increase for up to 2 weeks after taking k.

 

[Ruffian]

I read this article (click on the image) a few days ago about how ketamine exerts its antidepressant effects. Found it interesting.

This is a great article that I hope to finish one day after getting through the part about the mice being stressed. I eat meat, so it kind of makes me a hypocrite. But it looks very interesting and I'm a big believer in backing up someone's claim with scientific data.

I've noticed that many of you on here are suffering from depression, no big surprise there right? Also, most seem to be quite young. I suffered from mild to moderate depression at different times in my life, as most people on the planet do.

I suffer from Ehlers-Danlos syndrome, a connective tissue disorder which can (and does in my case) cause severe chronic pain. 10 yers ago I went to a pain specialist who thinking outside of the box treated me with Ketamine, sort of unheard of at the time. Not only did it help my pain, but once I reached the correct dosage (in my case .0.9 ml IM) I was immediately free of depression. I mean I was totally over my depression with one injection! This lasted for months, even when I stopped taking the ketamine. There is an approved nasal form called eskaetmine, however I have read that it's very expensive (Thanks big pharma), and Dr.'s use it as a last resort, when in my opinion it should be the gold standard of treatment. Will it work for everyone? There is not enough evidence, but before you take a permanent step, like ending your life, please try ketamine treatment, even if you have to acquire the ketamine on your own.

I'm not on this site because I'm depressed, I've lived a great life, I'm almost 60, and my disability has caused me to lose the ability to walk or do the things that I've always enjoyed, and my pain is most times unbearable, even with the large amount of opiates I take. I just know that ketamine could help some of you as it helped me, and knowing that I've been depression free for years has made my disease tolerable. Best of luck to you all and god bless you

I really wish more people and more psychiatrists would be willing to try this. If you are located in the US, would you mind PMing me and beginning a dialogue? I used to be happy, but the combo of psych meds I used to take imploded on me and almost killed me (twice.) Not on purpose, my kidneys could process them anymore. I also have developed chronic pain due to a rotator cuff tear and neuralgia. The depression is worse than the pain, but they definitely feed on each and create a vicious cycle. My current psychiatrist is to me, the lesser of the two evils, meaning he is reluctant to prescribe me additional meds (he's older, so his repertoire probably doesn't include ketamine as a therapeutic potential,) as opposed to other doctors I've had who want to through the latest atypical anti-psychotic at me regardless of the health consequences. Ugh. So if you feel comfortable sending a message, I would like to get a feel (or even a name) of your doctor or his/her practice. I would like to explore this and/or ECT before deciding to ultimately ctb.

Yeah I've been telling people on here to try ketamine. I don't think they understand how valuable it can be. The other day I had to defend myself from people accusing me of recommending psychedelics like ketamine. I'm glad that I am not the only one that knows the benefits of psychedelics, especially ketamine. Hopefully some people on here will be brave enough to give it a shot.

I actually had to stop reading certain posts because the amount of misinformation people (I'm assuming young,) on this site have about drugs and medications could fill a book. As in the size of War of Peace. I'm not saying it's great that I know as much I do; it's just that every drug I've ever taken, prescribed or unprescribed, I've tried to learn as much about as I can, while understanding there is a synergy that occurs when you start combining things. But a lot of questions I see here are pretty basic and border on ridiculous. Like stuff I learned from a basic Health class in high school in 1981, pre-internet. I'm in complete agreement with you that there are benefits at certain dosages of psychedelics. Idk if you ever saw it, but there's a movie about it called "Neurons to Nirvana." It also talks a little about how this organization called MAPS uses ecstasy in certain doses to treat PTSD in war veterans.

 

[GeorgeJL]

I actually had to stop reading certain posts because the amount of misinformation people (I'm assuming young,) on this site have about drugs and medications could fill a book. As in the size of War of Peace. I'm not saying it's great that I know as much I do; it's just that every drug I've ever taken, prescribed or unprescribed, I've tried to learn as much about as I can, while understanding there is a synergy that occurs when you start combining things. But a lot of questions I see here are pretty basic and border on ridiculous. Like stuff I learned from a basic Health class in high school in 1981, pre-internet. I'm in complete agreement with you that there are benefits at certain dosages of psychedelics. Idk if you ever saw it, but there's a movie about it called "Neurons to Nirvana." It also talks a little about how this organization called MAPS uses ecstasy in certain doses to treat PTSD in war veterans.

I'm 36 almost 37 years old. And have as much experience to make be feel like I've lived 3 lifetimes. I know shit that would make your head spin 3 ways from sunday, inside out and backward. LOL OK that is partly a joke but also dead on with how much I know about life. And yes I've known about MAPS for years as well as their trials for PTSD with MDMA.

 

[markg109]

I'm 36 almost 37 years old. And have as much experience to make be feel like I've lived 3 lifetimes. I know shit that would make your head spin 3 ways from sunday, inside out and backward. LOL OK that is partly a joke but also dead on with how much I know about life. And yes I've known about MAPS for years as well as their trials for PTSD with MDMA.

Haven't seen the movie, but it sound interesting. I've done a lot of research on Ketamine, in fact so much so that I self published a book, for obvious reasons, I won't disclose the title. I interviewed one Palliative Care specialist who told me that at a convention they were asked if you had one drug to choose on a desert island which would it be? Most chose Ketamine. The fact that it effects glutamate levels in such a profound way apparently makes it head and shoulders above SSRI's and the fact that it is an anesthetic as well, gives it dual properties. In fact in burn wards it's used to sedate patients due to the fact that no intubation is required. The problem lies in the fact that it is cheap and profit margins for drug companies are minimal, and after all isn't that what matters?

I read this article (click on the image) a few days ago about how ketamine exerts its antidepressant effects. Found it interesting.

I'd be more than happy to PM you, I'm new to this whole forum thing, and don't really know how to do that, if you could give me a head up, I'd appreciate it.

 

[Cevapcici]

What does IM stand for ? how did you use it when prescribed ?

Thanks in advance

 

[Superfluous]

A recent article in The Guardian on Ketamine:

https://www.theguardian.com/science/2019/mar/23/ketamine-can-it-really-be-antidepressant

Basically, ketamine itself has been known as a potential treatment for depression for many years, but as it's been around for so long no pharmaceutical company can make any money from it (out of patent and therefore now generic). As such, they are not prepared to invest in clinical trials (which are expensive) to get the drug FDA approved for the treatment of depression.

"Ketamine is made up of two mirror-image molecules, so in order to turn it into a potential cash cow, pharma company Janssen patented the left one – esketamine"

The approval of esketamine is the same story as omeprazole / esomeprazole.

When omeprazole was first developed, tested and approved, AstraZeneca (the patent holder) made a ton of cash from it. Once the patent was due to expired (2002), AstraZeneca launched esomeprazole (2001).

Omeprazole is also made up of 2 mirror-image molecules. Esomeprazole is the left-handed version. Little testing was required for FDA approval as it was already known to be safe. They simply had to prove its efficacy. And, as it was technically a new drug, they had the patent. All they had to do then was sell the product (and they are very good at that). Esomeprazole costs significantly more than omeprazole but is no more effective.

If your interested in reading more about how "evil" pharmaceutical companies are, read Bad Pharma by Ben Goldacre.

 

[markg109]

What does IM stand for ? how did you use it when prescribed ?

Thanks in advance

IM is injecting the drug into a muscle such as the buttocks, arms, etc.

A recent article in The Guardian on Ketamine:

https://www.theguardian.com/science/2019/mar/23/ketamine-can-it-really-be-antidepressant

Basically, ketamine itself has been known as a potential treatment for depression for many years, but as it's been around for so long no pharmaceutical company can make any money from it (out of patent and therefore now generic). As such, they are not prepared to invest in clinical trials (which are expensive) to get the drug FDA approved for the treatment of depression.

"Ketamine is made up of two mirror-image molecules, so in order to turn it into a potential cash cow, pharma company Janssen patented the left one – esketamine"

The approval of esketamine is the same story as omeprazole / esomeprazole.

When omeprazole was first developed, tested and approved, AstraZeneca (the patent holder) made a ton of cash from it. Once the patent was due to expired (2002), AstraZeneca launched esomeprazole (2001).

Omeprazole is also made up of 2 mirror-image molecules. Esomeprazole is the left-handed version. Little testing was required for FDA approval as it was already known to be safe. They simply had to prove its efficacy. And, as it was technically a new drug, they had the patent. All they had to do then was sell the product (and they are very good at that). Esomeprazole costs significantly more than omeprazole but is no more effective.

If your interested in reading more about how "evil" pharmaceutical companies are, read Bad Pharma by Ben Goldacre.

You are 100 percent correct

 

[Cevapcici]

IM is injecting the drug into a muscle such as the buttocks, arms, etc.

You are 100 percent correct

Thank you for precising ! I might consider this option.

 

[Fin]

This is a great article that I hope to finish one day after getting through the part about the mice being stressed. I eat meat, so it kind of makes me a hypocrite. But it looks very interesting and I'm a big believer in backing up someone's claim with scientific data.

I'm happy you like the idea of it. Think about the stress of the mice being relieved on ketamine to get over that part more easily.

I'd be more than happy to PM you, I'm new to this whole forum thing, and don't really know how to do that, if you could give me a head up, I'd appreciate it.

You may PM me anytime, but you mean attaching a link to an image? Just insert the image using the menu or Ctrl+P, then left-click on the image and "Insert link".

If your interested in reading more about how "evil" pharmaceutical companies are, read Bad Pharma by Ben Goldacre.

Very useful recommendation, thank you.

 

[Lary]

I've noticed that many of you on here are suffering from depression, no big surprise there right? Also, most seem to be quite young. I suffered from mild to moderate depression at different times in my life, as most people on the planet do.

Eu sofro da síndrome de Ehlers-Danlos, um distúrbio do tecido conectivo que pode (e no meu caso) causar dor crônica severa. 10 anos atrás, fui a um especialista em dor que, pensando fora da caixa, me tratou com ketamina, algo inédito na época. Não só ajudou a minha dor, mas uma vez que cheguei à dosagem correta (no meu caso, 0,9 ml IM) eu estava imediatamente livre de depressão. Quer dizer, eu superei totalmente minha depressão com uma injeção! Isso durou meses, mesmo quando parei de tomar a ketamina. Existe uma forma nasal aprovada chamada escaetina, no entanto eu li que ela é muito cara (graças à grande farmacêutica), e a Dra a usa como último recurso, quando na minha opinião deveria ser o padrão ouro do tratamento. Isso funcionará para todos? Não há provas suficientes, mas antes de dar um passo permanente, como acabar com a sua vida,

Eu não estou neste site porque estou deprimido, eu vivi uma ótima vida, eu tenho quase 60 anos, e minha deficiência me fez perder a habilidade de andar ou fazer as coisas que eu sempre gostei, e minha dor é insuportável na maioria das vezes, mesmo com a grande quantidade de opiáceos que tomo. Só sei que a cetamina pode ajudar alguns de vocês, uma vez que isso me ajudou, e saber que estou livre de depressão há anos tornou minha doença tolerável. Boa sorte para todos vocês e Deus te abençoe
[/CITAR]
Você fazia a aplicação ou o médico? Fui pesquisar sobre a Cetamina depois que li seu post. Achei bem interessante.