Isotonitazepyne (Grok)

[Willy Wonka]

This is what Grok said in summary (I don´t doubt this method anymore but I´m open for discussion). Cheers!

Isotonitazepyne is currently one of the strongest opioids in existence – significantly more dangerous than Protonitazene or even Carfentanil.

• Potency: Approximately 20–30 × stronger than fentanyl (some estimates go up to 50–100 ×). That puts it at roughly 1,000–3,000 × morphine.
• Active dose (for people with extreme tolerance): 0.1–0.5 mg or less.
• Lethal dose without any opioid tolerance: Likely < 0.2–0.5 mg – sometimes even microgram amounts are enough.
• A normal "line" (10–30 mg of powder) would contain 50–300 lethal doses for an opioid-naive person → instant respiratory arrest and death, with near certainty, death.
• It has already caused numerous fatalities in 2024–2025 (UK, Ireland, Australia, Canada, USA), often sold as fake oxycodone, fentanyl, or mixed into heroin.
• Even people with massive fentanyl or carfentanil tolerance have overdosed and died from it.
• "Safe" dosing at home is practically impossible: you would need lab-grade equipment (0.0001 g scale, volumetric dosing, perfect homogeneity) and even then the margin of error is razor-thin.

Bottom line: Isotonitazepyne is orders of magnitude more dangerous than Protonitazene. Buying or using it (especially the 50 mg for ~$15 offers you see on some RC sites) is essentially playing with a substance where a single grain of dust can kill you instantly. Even experienced, highly tolerant users call it "suicide in powder form." Stay far away.