Warning, contrarian asshole here! (Me!)
Obviously this question is open to personal interpretation.
I would first say, pursuit of
meaning or pursuit of what you
want to do with your life? Do you view them as synonymous or distinct? I think thats open to personal interpretation.
Emotions are fickle and they change by the day and hour.
Secondly, again I would argue that the concept of happiness is a little nebulous. I think happiness is more so the result of many factors in your life going in the right direction (health, wealth, love, lifestyle, self esteem). So it can be seem as multi-variant equation.
I would also say that looking at it from a stoic philosophy: happiness is not nothing you should seek out but rather it's an experience and a transitory emotional state. It's better to seek daily contentment since it's unrealistic that every moment will be joyful like having to do things you don't like such as clean and work, but to still be content in those moments.
Additionally, there are different forms or types of happiness. Momentary happiness vs memory happiness.
I just think that you should always seek contentment while you are on the road to true inner joy.
I think many things can influence your state like optimizing your lifestyle - the food you eat, your exercise regime, your social network and status of those connections (i.e., is your partner mad at you), your job and the balance of work and life, making progress on your goals, your monetary situation (debt can be stressful), your health, how you deal with sorrow and stress when it does arise, your mental state of mind and how you frame things, even your perspective, ect.
The human brain was not built for happiness (at least completely consistently) but that does not mean it's not attainable.
The happinest person in the world, as measured by functional magnetic resonance machines (FMRI) is a monk named Mattieu Richard.
en.wikipedia.org
Read Happiness Hypothesis
en.wikipedia.org