D
diyCTB
Mage
- Oct 28, 2018
- 575
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Alprazolam is a benzodiazepine.
Alprazolam is the chemical name, the trademark name is Xanax.
The interaction is mediated by the hepatic enzyme CYP450 3A4. Cimetidine is a moderate inhibitor of multiple CYP's, so it should result in less first-pass metabolism of Alprazolam. If anything this is desirable for the effects most people are looking to get from benzo's on this forum as it will result in higher systemic concentrations of Alprazolam, thereby making each mg of the compound more sedating and may even get into the realm of respiratory depression if you combine them in high enough quantities. If you REALLY want to get the most out of this though, use grapefruit juice as well. The combination of Cimetidine and grapefruit juice should result in a near-complete blockade of Alprazolam metabolism, meaning the nearly full dose of each tablet should be present in serum (effectively getting you more drug per pill). Hell, you might even be able to get near IV-administration levels of Alprazolam that way.Hi,
Is Alprazolam good substitute for benzodiazepines?
I also checked drug interactions and saw that there is a serious interaction between Tagamet and Alprazolam but they don't explain what kind of interaction.
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Yes I plan to do the sameI want to take Alprazolam after drinking SN since it is quick acting.
Sorry bro .. Not sure abt that .. True the potency will reduce but taking twice the dose , am not sure .. May be someone els on the site may be well Informed@I screwed up I have Alprazolam pack but it expired in 2018. Do you think taking twice the dose will compensate for some loss in its potency?